Enhanced antitumor efficacy of arginine modified amphiphilic nanoparticles co-delivering doxorubicin and iSur-pDNA via the multiple synergistic effect

Song, Yudong; Tang, Cui; Chen, Yin

doi:10.1016/j.biomaterials.2017.10.010

Cited by 30 publications

(18 citation statements)

References 36 publications

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“…[ 131,159,160,162–165 ] Two studies involving positively charged particles, however, reported caveolae‐mediated endocytosis and macropinocytosis as the only uptake mechanisms. [ 108,166 ]…”

Section: Cellular Uptakementioning

confidence: 99%

“…Overview of identified cellular uptake mechanisms of chitosan particles found in 12 recent articles (2012–2019). [ 108,131,159–168 ] …”

Section: Cellular Uptakementioning

confidence: 99%

“…Moreover, the particles were mainly localized in the endoplasmic reticulum and Golgi complex as evaluated using CLSM. [ 166 ] The third study reported cholesterol modified chitosan (165 nm and +25 mV) used for the co‐delivery of curcumin and siRNA in to A549 cells. The cellular uptake of particles measured from fluorescently labelled siRNA and the inherent fluorescence of curcumin indicated clathrin‐mediated pathway as found by using endocytic inhibitors.…”

Section: Cellular Uptakementioning

confidence: 99%

“…[131,159,160,[162][163][164][165] Two studies involving positively charged particles, however, reported caveolae-mediated endocytosis and macropinocytosis as the only uptake mechanisms. [108,166] Some of these studies involved positively charged particles encapsulating chemotherapeutics for active targeting. HA-chitosan particles (207 nm and +25 mV) were evaluated for curcumin delivery in C6 (glioma) cells and by measuring the fluorescence from curcumin found to be taken up via different endocytic routes including clathrin-and caveolaemediated endocytosis, macropinocytosis, and CD44 receptor dependent endocytosis.…”

Section: Cellular Uptake Mechanism Of Chitosan Particlesmentioning

confidence: 99%

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Chitosan Nanomedicine in Cancer Therapy: Targeted Delivery and Cellular Uptake

Mushtaq

Anitha

et al. 2021

Macromolecular Bioscience

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Nanomedicine has gained much attention for the management and treatment of cancers due to the distinctive physicochemical properties of the drug‐loaded particles. Chitosan's cationic nature is attractive for the development of such particles for drug delivery, transfection, and controlled release. The particle properties can be improved by modification of the polymer or the particle themselves. The physicochemical properties of chitosan particles are analyzed in 126 recent studies, which allows to highlight their impact on passive and active targeted drug delivery, cellular uptake, and tumor growth inhibition (TGI). From 2012 to 2019, out of 40 in vivo studies, only 4 studies are found reporting a reduction in tumor size by using chitosan particles while all other studies reported tumor growth inhibition relative to controls. A total of 23 studies are analyzed for cellular uptake including 12 studies reporting cellular uptake mechanisms. Understanding and exploiting the processes involved in targeted delivery, endocytosis, and exocytosis by controlling the physicochemical properties of chitosan particles are important for the development of safe and efficient nanomedicine. It is concluded based on the recent literature available on chitosan particles that combination therapies can play a pivotal role in transformation of chitosan nanomedicine from bench to bedside.

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Section: Cellular Uptakementioning

confidence: 99%

“…Overview of identified cellular uptake mechanisms of chitosan particles found in 12 recent articles (2012–2019). [ 108,131,159–168 ] …”

Section: Cellular Uptakementioning

confidence: 99%

Section: Cellular Uptakementioning

confidence: 99%

Section: Cellular Uptake Mechanism Of Chitosan Particlesmentioning

confidence: 99%

See 2 more Smart Citations

Chitosan Nanomedicine in Cancer Therapy: Targeted Delivery and Cellular Uptake

Mushtaq

Anitha

et al. 2021

Macromolecular Bioscience

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“…The canonical NLS is a short, positively-charged peptide sequence rich in basic amino acids (e.g., the transactivator of transcription (TAT) peptide (YGRKKRRQRRR)) [122]. Recent studies have shown that NP-drug constructs bearing such peptide motifs can translocate NPs and appended drug cargos into the nucleus of cells and release the drug inside the nucleus which can dramatically (1) improve the efficacy of therapy, (2) circumvent multidrug resistance, and (3) reduce off-target toxicity [123,124,125,126].…”

Section: Active Subcellular Targeting Of Np-drug Systemsmentioning

confidence: 99%

Active Cellular and Subcellular Targeting of Nanoparticles for Drug Delivery

Nag

Delehanty

2019

Pharmaceutics

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Nanoparticle (NP)-mediated drug delivery (NMDD) for active targeting of diseases is a primary goal of nanomedicine. NPs have much to offer in overcoming the limitations of traditional drug delivery approaches, including off-target drug toxicity and the need for the administration of repetitive doses. In the last decade, one of the main foci in NMDD has been the realization of NP-mediated drug formulations for active targeted delivery to diseased tissues, with an emphasis on cellular and subcellular targeting. Advances on this front have included the intricate design of targeted NP-drug constructs to navigate through biological barriers, overcome multidrug resistance (MDR), decrease side effects, and improve overall drug efficacy. In this review, we survey advancements in NP-mediated drug targeting over the last five years, highlighting how various NP-drug constructs have been designed to achieve active targeted delivery and improved therapeutic outcomes for critical diseases including cancer, rheumatoid arthritis, and Alzheimer’s disease. We conclude with a survey of the current clinical trial landscape for active targeted NP-drug delivery and how we envision this field will progress in the near future.

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