Enhanced antitumor effect via amplified oxidative stress by near-infrared light-responsive and folate-targeted nanoplatform

Abstract

The efficiency of producing hydroxyl radicals (·OH) from hydrogen peroxide (H2O2) catalyzed by different iron compounds have been explored extensively. Exclusively, ferrocenecarboxylic acid (FCA) showed the best catalyzed activity for ·OH generation. Then, we designed and prepared near-infrared (NIR) light-responsive and folate-targeted nanoplatform, which co-delivered FCA, cisplatin and indocyanine green (ICG) for improving antitumor therapy through amplified oxidative stress. The noteworthy observation is that under the irradiation of NIR light, the lecithin structure could able to depolymerize through the photothermal conversion mechanism of encapsulated dye ICG, which has achieved an intelligent release of drugs. In addition, the released cisplatin is not only fully effective to damage the DNA of cancer cells but it is able to induce the production of intracellular H2O2, which could further be catalyzed by FCA to generate toxic ·OH for oxidative damage via Fenton and Haber–Weiss reaction. This original strategy may provide an efficient way for improved chemotherapy via amplified oxidative stress.

Codelivery of satraplatin and aminopyrrolic receptor with Pluronic F127-based polyaniline nanoparticles with NIR induced release for combined chemotherapy

“…TEM was used to observe the appearance of the prepared vesicles (figures 3(a) and (b)), It shows that the average diameters of Pt-ARNPs was 128 nm with regular spherical morphology and good monodispersity. Moreover, DLS reveals that an average hydrodynamic size of the nanoparticles is 150 nm (figure 3(d)), which was considered as a favorable partial size for effective cellular uptake [27,28]. In addition, the zeta potential of the nanoparticles was −11.5 mV (figure 3(e)).…”

Development of novel polymeric nanoagents and their potential in cancer diagnosis and therapy runing title: Polymeric nanoagents for cancer theranostics

“…It is worth noting that premature drug leakage, low drug delivery efficiency and defective cellular uptake are considerable (Almawash et al, 2018), breast cancer (Lu et al, 2020), and prostate cancer (Xiao et al, 2022). In addtion, glycol chitosan (GC)-based polymeric nanoagents have been widely used for delivering chemotherapeutic drugs via hydrophobic interactions, such as paclitaxel (Hao et al, 2019), cisplatin (Wang et al, 2021), camptothecin (CPT) (Dutta et al, 2021), or DTX (Ren et al, 2021), resulting in maximized therapeutic efficacies.…”