Enhanced antitumor effect of l-buthionine sulfoximine or ionizing radiation by copper complexes with 2,2´-biquinoline and sulfonamides on A549 2D and 3D lung cancer cell models

Vargas, J F Cadavid; Perez, Consuelo; Soria, Delia Beatriz; Güerci, Alba Mabel; Virgilio, Ana Laura Di

doi:10.1007/s00775-022-01933-8

Cited by 1 publication

(1 citation statement)

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“…In terms of the ability to detect small nodules in the lungs, it is 10 times higher than that of chest X‐rays, and it can detect small lung cancers with a diameter of <1 cm and only local infiltration without distant metastasis, 80% to 90% of tumors can be cured with adequate surgical resection. The advantages of LDCT are obvious, including: (1) early detection—it can detect small lesions of early lung cancer, and at the same time can detect other chest tumors, some vascular lesions radiation, and non‐tumor lesions; (2) low dose—uses only ~10% of the conventional CT radiation dose; (3) fast and non‐invasive—scanning is completed within 10 seconds and is non‐invasive; (4) high detecting probability and diagnostic accuracy—it can show more than 90% match with the postoperative pathology 32–38 …”

Section: Introductionmentioning

confidence: 99%

Investigation on the incidence and risk factors of lung cancer among Chinese hospital employees

Chen

Kang

et al. 2022

Thoracic Cancer

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Objective In recent years, the lung cancer incidence has grown and the population is younger. We intend to find out the true detection rate of pulmonary nodules and the incidence of lung cancer in the population and search for the risk factors. Method Hospital employees ≥40 years old who underwent low‐dose computed tomography (CT) lung cancer screening from January 2019 to March 2022 were selected to record CT‐imaging characteristics, pathology, staging, and questionnaires to investigate past history, smoking history, diet, mental health, etc. PM2.5 and radiation intake in radiation‐related occupation received monitoring in hospital. Result The detection rate of suspicious pulmonary nodules was 9.1% (233/2552), and the incidence rate of lung cancer (including adenocarcinoma in situ) was 4.0% (103/2552). Morbidity among doctors, nurses, technicians, administers, and logistics was no difference (p = 0.184), but higher in women than in men (4.7% vs 2.4% p = 0.002). The invasiveness increased with age and CT density of nodules (p = 0.018). The relationship between lung cancer morbidity and PM2.5 was not clear (p = 0.543); and no lung cancer has been found in employees related ionizing radiation. Conclusion The high screening rate has brought about a high incidence of lung cancer. At present, the risk factor analysis of lung cancer based on small samples cannot find the direct cause. Most of the ground glass opacity (GGO)s detected by LDCT screening are indolent, but there are also rapidly progressive lung cancer. A predictive model to identify active and indolent GGO is necessary.

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Section: Introductionmentioning

confidence: 99%