Enhanced antitumor activity of irinotecan combined with propolis and its polyphenolic compounds on Ehrlich ascites tumor in mice

Benković, Vesna; Knežević, Anica Horvat; Brozović, Gordana; Knežević, Fabijan; Đikić, Domagoj; Bevanda, Milenko; Basić, Ivan; Oršolić, Nada

doi:10.1016/j.biopha.2007.02.012

Cited by 43 publications

(32 citation statements)

References 23 publications

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“…Several studies using animal models also support this part of the hypothesis [13][14][15]. Our previous work [5] has shown that WSDP, EEP, naringin, and quercetin given in combination with chemotherapeutic agent irinotecan delayed Ehrlich ascites tumor (EAT) growth and increased life span of EATbearing mice. EEP and WSDP in combined treatment with irinotecan increased median survival time (59.00 ± 9.87; 70.00 ± 9.22) comparing to control group or the group treated with irinotecan alone (39.00 ± 2.67).…”

Section: Discussionmentioning

confidence: 89%

“…Epidemiology and animal studies have suggested that a high intake of flavonoids may be linked to a reduced risk of cancer [31], coronary disease [32], and osteoporosis [33]. Flavonoids have biochemical and pharmacological activities beneficial for human health, including antioxidant, anticarcinogenic, anti-inflammatory, antiproliferative, antiangiogenic, and antiestrogenic, estrogenic effects (see review 4), and that their ingestion produces no or very little toxicity [3][4][5]30]. A few in vivo studies support the concept that antioxidants selectively enhance the effect of standard therapy on tumor cells by increasing tumor response.…”

Section: Discussionmentioning

confidence: 99%

“…Since combined treatment with propolis and its polyphenolic compounds have enhanced antitumor activity of irinotecan on the Ehrlich ascites tumor in mice increasing the survival time of the animals and tumor regression after treatment [5], we concentrated our attention on the effect of these treatments on haematopoiesis. As shown in Table 3, a significant decrease in number of WBC was seen in irinotecan-treated mice.…”

Section: Determination Of Total Number Of Cells In the Peritoneal Cavitymentioning

confidence: 99%

“…Many authors have previously shown that these flavonoids regulate genes that are involved in the control of cell proliferation, cell cycle, apoptosis, oncogenesis, transcription regulation, angiogenesis, and cancer cell invasion and metastasis [4]. Our recent data showed that preventive treatment of a water or an ethanolic extract of propolis (WSDP, EEP) in combination with irinotecan are capable of increasing the survival time of mice bearing tumor and decrease tumor growth [5].…”

Section: Introductionmentioning

confidence: 97%

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Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan

et al. 2009

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Despite the excellent chemotherapeutic effect of irinotecan, its cytotoxicity and genotoxicity in normal cells remains a major problem in chemotherapy. This study was carried out to find whether propolis preparations and related flavonoids (quercetin, naringin) might enhance irinotecan-induced cytotoxicity to tumor cells in mice bearing Ehrlich ascites tumors (EAT) while protecting normal blood, liver, and kidney cells. The preparation of propolis and their flavonoids were given to mice intraperitoneally at a dose of 100 mg kg(-1) body weight for three consecutive days before the ip injection of EAT cells (2×10(6)). Irinotecan was administered ip at dose of 50 mg kg(-1) on days 3, 4, and 5 after tumor cell inoculation. The combination treatment resulted in substantial inhibition of the growth of EAT cells as well as treatment with quercetin or irinotecan alone, whereas other treatment by itself showed little effect. However, when mice were pre-treated with test components prior to irinotecan, the frequencies of irinotecan-induced micronuclei (MN) was decreased but in mice bearing tumor QU and EEP increased number of micronucleated cells. Propolis preparation and related flavonoids were found to exhibit an important immunomodulatory effect and could decrease irinotecan-induced toxic and genotoxic effects to normal cells without effecting irinotecan cytotoxicity in EAT cells.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Determination Of Total Number Of Cells In the Peritoneal Cavitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan

et al. 2009

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“…Benkovic et al [42] investigated the anticancer drug irinotecan combined or not with ethanolic extract of propolis, a water-soluble derivative of propolis (WSDP) and polyphenolic compounds (quercitin and naringin) against EAT inoculated i.p. (1×10 6 cells/animal) in male Swiss albino mice.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Antineoplasic Activity of Pleurotus ostreatus

Wolff

Wisbeck

Silveira

et al. 2008

Appl Biochem Biotechnol

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The objectives of this work were to evaluate the antimicrobial and antineoplasic activity of Pleurotus ostreatus DSM 1833. To study the antimicrobial activity, the following extracts were prepared: water infusion of the fresh fruiting bodies (B1), dehydrated fruiting bodies (B2), fresh mycelium (M1), and dehydrated mycelium (M2). Polysaccharides from the fresh mycelium were also obtained by water infusion followed by ethanol treatment (EP). The extracts were tested against Candida albicans, Escherichia coli, and Bacillus subtilis. To investigate the antineoplasic effect of P. ostreatus, the culture broth in natura, the extract from the culture broth (ECB), and the extract from the fruiting bodies were tested in female Swiss albino mice inoculated with the Ehrlich ascitic tumor (EAT). B1, B2, and M1 showed more than 50.0% inhibition against C. albicans. M2 presented a high degree of inhibition against E. coli (87.5%) and B. subtilis (57.5%), while EP was not effective. All the tested substances inhibited the development of EAT at levels near 70% when injected intraperitoneally in mice. The highest tumor inhibition (76%) was achieved for the treatment with ECB. The intragastric treatment did not promote any reduction in tumor cell development, independent of the test substance.

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Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

El-Guendouz

Lyoussi

Miguel

2019

Chemistry & Biodiversity

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This review updates the information upon the chemical composition of propolis from all Mediterranean countries as well as their biological properties and applications. The non‐volatile fraction of propolis was characterized by the presence of phenolic acids and their esters and flavonoids. Nevertheless, in some countries, diterpenes were also present: Sicily (Italy), Croatia, Malta, Creta (Greece), Turkey, Cyprus, Egypt, Libya, Algeria and Morocco. The volatile fraction of propolis was characterized by the presence of benzoic acid and its esters, mono‐ and sesquiterpenes, being the oxygenated sesquiterpene β‐eudesmol characteristic of poplar propolis, whereas the hydrocarbon monoterpene α‐pinene has been related with the presence of conifers. Regardless the chemical composition, there are common biological properties attributed to propolis. Owing to these attributes, propolis has been target of study for applications in diverse areas, such as food, medicine and livestock.

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Enhanced antitumor activity of irinotecan combined with propolis and its polyphenolic compounds on Ehrlich ascites tumor in mice

Cited by 43 publications

References 23 publications

Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan

Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan

Antimicrobial and Antineoplasic Activity of Pleurotus ostreatus

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

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