Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma: an experimental study

Pateliya, Bharat; Burade, Vinod; Goswami, Sumanta

doi:10.1007/s00210-021-02104-3

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…The treatments led to a reduction in tumor weight and an increase in the necrotic area without any effect on blood glucose levels, body weight, or survival. The same results were observed when mice with orthotopic 4T1-induced breast carcinoma were treated with naringenin, metformin, and lipo-dox [ 128 ].…”

Section: Naringenin and Hesperidin: An Overviewsupporting

confidence: 68%

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Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

et al. 2023

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Citrus (genus Citrus L.) fruits are essential sources of bioactive compounds with antioxidant properties, such as flavonoids. These polyphenolic compounds are divided into subclasses, in which flavanones are the most prominent. Among them, naringenin and hesperidin are emerging compounds with anticancer potential, especially for breast cancer (BC). Several mechanisms have been proposed, including the modulation of epigenetics, estrogen signaling, induction of cell death via regulation of apoptotic signaling pathways, and inhibition of tumor invasion and metastasis. However, this information is sparse in the literature and needs to be brought together to provide an overview of how naringenin and hesperidin can serve as therapeutic tools for drug development and as a successful co-adjuvant strategy against BC. This review detailed such mechanisms in this context and highlighted how naringenin and hesperidin could interfere in BC carcinogenesis and be helpful as potential alternative therapeutic sources for breast cancer treatment.

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Section: Naringenin and Hesperidin: An Overviewsupporting

confidence: 68%

“…Naringenin also acts as an adjuvant in breast cancer [ 108 , 128 ]. MDA-MB-231 and MCF-10A treated with pure naringenin (NGEN) and naringenin complexed with copper (Cu(II)) and 2,2′-bipyridine (NGENCuB) were tested.…”

Section: Naringenin and Hesperidin: An Overviewmentioning

confidence: 99%

Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

et al. 2023

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“…The anticancer ability of flavonoids has been the subject of great research interest in recent years. Previous studies focusing on anticancer abilities have demonstrated that MCF-7 breast cancer cell proliferation was inhibited in a dose-dependent manner after exposure to liquiritigenin, naringenin, and hesperetin [29][30][31]. Liquiritigenin was found to effectively inhibit the invasiveness of breast cancer cells by inhibiting DNA methyltransferase (DNMT) activity and increasing (breast cancer 1) BRCA1 expression [29], and naringenin treatment regulated endoplasmic reticulum (ER)-stress mediation to prevent breast cancer cell proliferation [32].…”

Section: Discussionmentioning

confidence: 99%

Biotransformation of Flavonoids Improves Antimicrobial and Anti-Breast Cancer Activities In Vitro

Hao

Wei

Wang

et al. 2021

Foods

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Coarse cereals are rich in flavonoids, which are bioactive substances with a wide range of functions. Biotransformation is considered an emerging approach to methylate flavonoids, displaying prominent regio- and stereoselectivity. In the current study, liquiritigenin, naringenin, and hesperidin flavonoids were biotransformed using O-methyltransferases that were heterologously expressed in Saccharomyces cerevisiae BJ5464-NpgA. Nuclear magnetic resonance (NMR) spectroscopy was used together with high-resolution mass spectroscopy analysis to determine the structures of the resulting methylated transformants, and their antimicrobial and antiproliferation activities were also characterized. Among the five methylated flavonoids obtained, 7-methoxy-liquiritigenin had the strongest inhibitory effect on Candida albicans SC5314 (C. albicans SC5314), Staphylococcus aureus ATCC6538 (S. aureus ATCC6538), and Escherichia coli ATCC25922 (E. coli ATCC25922), which increased 7.65-, 1.49-, and 0.54-fold in comparison to the values of their unmethylated counterparts at 200, 250, and 400 μM, respectively. The results suggest that 3’-methoxyhesperetin showed the best antiproliferative activity against MCF-7 cells with IC50 values of 10.45 ± 0.45 µM, which was an increase of more than 14.35-fold compared to that of hesperetin. These results indicate that methylation enhances the antimicrobial activities and antiproliferative effects of flavonoids. The current study provides an experimental basis for further research on flavonoids as well as flavonoid-containing crops in the development of antimicrobial and anti-breast cancer drugs in addition to supplementary and health foods. The biotransformation method is ideal, as it represents a means for the sustainable production of bioactive flavonoids.

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“…Pateliya et al 40 evaluated the effects of metformin and naringenin in combination with doxorubicin chemotherapy in methyl nitrosourea-induced experimental breast carcinomas. They concluded that both these selected compounds along with doxorubicin proved a noteworthy decline in cancer weight as well as its volume in the 4T1-induced orthotopic mouse model, suggesting a combination treatment to enhance anticancer action against in vivo experiments.…”

Section: Discussionmentioning

confidence: 99%

Toxicological effects of dimethlybenzeneanthracene in Balb C mice and pharmacological intervention by silk sericin–conjugated silver nanoparticles

Mumtaz,

Ali,

Pervaiz

et al. 2024

Science Progress

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Polycyclic aromatic hydrocarbons (PAHs) such as 7, 12-dimethylbenzneanthracene (DMBA), due to long-term bioaccumulation cause serious physiological processes and behavioral dysfunctions such as cancer, ageing, and hypertension. Silk sericin (SS) is instrumental in cancer applications due to presence of flavonoids and carotenoids which are natural pigments, present in the layer of sericin that has antioxidant and antityrosinase activity. It reduces oxidative stress and suppresses cancer cytokines while interacting with reactive oxygen species (ROS) to stand against lipid peroxidation. Recent research was focused to calculate the pharmacological intervention of sericin-conjugated silver nanoparticles (S-AgNO3 NPs) against DMBA-induced toxicity. For this purpose, SS protein was extracted from silkworm cocoons by degumming process and the prepared S-AgNO3 NPs via a green synthesis. In female albino mice, a total of 50 mg/kg oral administration of DMBA was used for the induction of toxicity which required almost 8 to 10 weeks approximately. After 60 days of experimentation, mice were dissected, blood samples were collected for further hematological and biochemical analysis and were euthanized via cervical dislocation. There was a significant rise in the level of red blood cells, platelets, lymphocytes, and hemoglobin at the highest applied concentration of sericin and its nanoparticles. Similarly, a reasonable decline was observed in the level of white blood cells, neutrophils, eosinophils, and monocytes as compared to the cancer-inducing group. The level of glutathione, lactate dehydrogenase, and alkaline phosphatase as well as immunoglobulins such as immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) were significantly reduced in all treatment groups as compared to the DMBA-induced group. Substantial effects were demonstrated in response to S-AgNO3 NPs II (T) at the highest concentrations (200 mg/kg, BW) as follows: glutathione (2.42 ± 0.26 μmol/L), lactate dehydrogenase (493.6 ± 5.78 U/L), alkaline phosphatase (158.4 ± 6.35 U/L), IgA (4.22 ± 0.19 g/L), IgG (70 ± 1.70 g/L), and IgM (4.76 ± 0.12). The histopathological study of the liver, kidneys, and brain revealed that the DMBA-induced group showed cytotoxic effects against all selected organs of mice that were recovered by treatment of selective compounds but highly effective recovery was seen in S-AgNO3 NPs II (T). These results concluded that silk S-AgNO3 NPs showed significant pharmacological potential against cancer-inducing toxicity.

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Enhanced antitumor activity of doxorubicin by naringenin and metformin in breast carcinoma: an experimental study

Cited by 9 publications

References 36 publications

Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

Biotransformation of Flavonoids Improves Antimicrobial and Anti-Breast Cancer Activities In Vitro

Toxicological effects of dimethlybenzeneanthracene in Balb C mice and pharmacological intervention by silk sericin–conjugated silver nanoparticles

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