Enhanced Antioxidant, Antiviral, and Anticancer Activities of the Extract of Fermented Egyptian Rice Bran Complexed with Hydroxypropyl-β-cyclodextrin

Fahmy, Sherif Ashraf; Nematallah, Khaled A.; Mahdy, Noha Khalil; El‐Askary, Hesham I.; Meselhy, Meselhy Ragab; Azzazy, Hassan M.E.

doi:10.1021/acsomega.2c01281

Cited by 11 publications

(13 citation statements)

References 47 publications

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“…Supramolecular macrocyclic nanosystems, including calix[ n ]arenes, cyclodextrins, pillar[ n ]arenes, cucurbit[ n ]urils (CBs), etc. , have shown dynamic regulation characteristics and multifunctional properties. − The structure of macrocyclic compounds can be altered in response to various external stimuli (temperature, pH, light, etc. ) thus controlling the release of their loaded guest molecules .…”

Section: Supramolecular Nanovesicles For Cancer Targeted-deliverymentioning

confidence: 99%

Stimuli-Responsive Cucurbit[n]uril-Based Supramolecular Nanocarriers for Delivery of Chemotherapeutics

Alabrahim

Fahmy²,

Azzazy

2023

ACS Appl. Nano Mater.

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Chemotherapeutics commonly exhibit low bioavailability and systemic adverse effects. Supramolecular nanovesicles, such as pillar[n]arenes, calix[n]arenes, cucurbit[n]urils (CBs), and cyclodextrins, have been introduced as promising nanocarriers due to their remarkable encapsulation capacity and ability to host hydro-philic/-phobic guest molecules. Additionally, such nanovesicles can be decorated with various stimuli-responsive entities to enable drug targeting and controlled drug release. Self-assembly of amphiphilic cavitands and host−guest complexation represent the two common approaches for preparation of supramolecular nanovesicles with customizable surfaces capable of accommodating different biologically active guest molecules. CBs have been used as smart and multifunctional host macromolecules in cancer therapy. CBs are fabricated via a condensation reaction between formaldehyde and glycoluril units generating barrel-shaped supramolecules with partially enclosed cavities. The unique structure of CBs surrounding an internal hydrophobic cavity allows them to accommodate cationic and neutral guest molecules via ion-dipole and hydrophobic interactions, respectively. Additionally, CBs are stable, safe, and biocompatible, and their surfaces can be decorated with various functional targeting moieties. These advantages have promoted CBs as promising candidates for stimuli-responsive targeted delivery of chemotherapeutics. This review presents the most recent advances in the design of stimuli-responsive nanosystems based on CBs for effective cancer treatment.

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Section: Supramolecular Nanovesicles For Cancer Targeted-deliverymentioning

confidence: 99%

Stimuli-Responsive Cucurbit[n]uril-Based Supramolecular Nanocarriers for Delivery of Chemotherapeutics

Alabrahim

Fahmy²,

Azzazy

2023

ACS Appl. Nano Mater.

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“…Also the survival rates were best for NP-treated mice with 50 days' life as compared to 41 days for plain PTX (Yuan et al, 2016). Fahmy et al (2022) explored the properties of fermented Egyptian rice bran extract (FRBE) for their anticancer and antioxidative characteristics. Solubility and bioavailability of the phenolic chemical compounds found in the extract was improved after it was complexed with HP-β-CD using the thin-film hydration method.…”

Section: Cervical Cancermentioning

confidence: 99%

Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review

Karthic

Roy

Lakkakula

et al. 2022

Front. Cell Dev. Biol.

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Cancer is still one of the world’s deadliest health concerns. As per latest statistics, lung, breast, liver, prostate, and cervical cancers are reported topmost worldwide. Although chemotherapy is most widely used methodology to treat cancer, poor pharmacokinetic parameters of anticancer drugs render them less effective. Novel nano-drug delivery systems have the caliber to improve the solubility and biocompatibility of various such chemical compounds. In this regard, cyclodextrins (CD), a group of natural nano-oligosaccharide possessing unique physicochemical characteristics has been highly exploited for drug delivery and other pharmaceutical purposes. Their cup-like structure and amphiphilic nature allows better accumulation of drugs, improved solubility, and stability, whereas CDs supramolecular chemical compatibility renders it to be highly receptive to various kinds of functionalization. Therefore combining physical, chemical, and bio-engineering approaches at nanoscale to specifically target the tumor cells can help in maximizing the tumor damage without harming non-malignant cells. Numerous combinations of CD nanocomposites were developed over the years, which employed photodynamic, photothermal therapy, chemotherapy, and hyperthermia methods, particularly targeting cancer cells. In this review, we discuss the vivid roles of cyclodextrin nanocomposites developed for the treatment and theranostics of most important cancers to highlight its clinical significance and potential as a medical tool.

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“…Thus, phytochemicals developed from natural extracts are recognized as a promising source of more effective and safer anticancer drugs than synthetic ones. Several studies have reported the potential applications of phytochemicals in cancer therapy [ 9 , 10 , 11 ], such as Peganum harmala L. seeds extract [ 12 ], [ 13 ], betaine (extracted from wheat germ and spinach) [ 14 ], fermented Egyptian rice bran ( Oryza sativum ) [ 15 ], and ozonated olive oil [ 16 ]. In addition, psoralidin (Ps) is a natural phenolic coumarin phytochemical ( Figure 1 ) extracted from the seeds of Psoralea corylifolia L. grown in various areas in India, Europe, and Asia [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells

Youness¹,

Al-mahallawi

Mahmoud³

et al. 2023

Polymers

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This study aims to design and optimize chitosan-coated bilosomal formulations loaded with psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and boosted apoptotic and necrotic effects. In this regard, uncoated bilosomes loaded with Ps (Ps/BLs) were nanoformulated using the thin-film hydration technique using different molar ratios of phosphatidylcholine (PC), cholesterol (Ch), Span 60 (S60), and sodium deoxycholate (SDC) (1:0.4:0.2:0.125, 1:0.4:0.2:0.25, and 1:0.4:0.2:0.5, respectively). The best-optimized formulation with respect to size, PDI, zeta potential, and EE% was selected and then coated with chitosan at two different concentrations (0.125 and 0.25 w/v%), forming Ps-CS/BLs. The optimized Ps/BLs and Ps-CS/BLs showed a spherical shape and relatively homogenous size with negligible apparent agglomerations. Additionally, it was demonstrated that coating Ps/BLs with chitosan has significantly increased the particle size from 123.16 ± 6.90 in the case of Ps/BLs to 183.90 ± 15.93 nm in the case of Ps-CS/BLs. In addition, Ps-CS/BLs exhibited higher zeta potential (+30.78 ± 1.44 mV) as compared to Ps/BLs (−18.59 ± 2.13 mV). Furthermore, Ps-CS/BL showed enhanced entrapment efficiency (EE%) of 92.15 ± 7.20% as compared to Ps/BLs (68.90 ± 5.95%). Moreover, Ps-CS/BLs exhibited a more sustained release behavior of Ps compared to Ps/BLs over 48 h, and both formulations were best obeying the Higuchi diffusion model. More importantly, Ps-CS/BLs displayed the highest mucoadhesive efficiency% (74.89 ± 3.5%) as compared to Ps/BLs (26.78 ± 2.9%), indicating the ability of the designed nanoformulation to improve oral bioavailability and extend the residence time inside the gastrointestinal tract upon oral administration. Moreover, upon evaluating the apoptotic and necrotic effects of free Ps and Ps-CS/BLs on human breast cancer cell lines (MCF-7) and human lung adenocarcinoma cell lines (A549), there was a dramatic increase in the percentages of the apoptotic and necrotic cell compared to the control and free Ps. Our findings suggest the possible oral use of Ps-CS/BLs in hampering breast and lung cancers.

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Enhanced Antioxidant, Antiviral, and Anticancer Activities of the Extract of Fermented Egyptian Rice Bran Complexed with Hydroxypropyl-β-cyclodextrin

Cited by 11 publications

References 47 publications

Stimuli-Responsive Cucurbit[n]uril-Based Supramolecular Nanocarriers for Delivery of Chemotherapeutics

Stimuli-Responsive Cucurbit[n]uril-Based Supramolecular Nanocarriers for Delivery of Chemotherapeutics

Cyclodextrin nanoparticles for diagnosis and potential cancer therapy: A systematic review

Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells

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