Enhanced antimalalarial activity of a prolonged release in situ gel of arteether–lumefantrine in a murine model

Dawre, Shilpa; Pathak, Sulabha; Sharma, Shobhona; Devarajan, Padma V.

doi:10.1016/j.ejpb.2017.11.002

Cited by 20 publications

(12 citation statements)

References 28 publications

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“…Moreover, histopathological examination showed that this formulation is safe on the nasal mucosa of mice (Mahajan et al, 2011). Although other studies have shown that in-situ gel prolongs drug release (Mahajan et al, 2011, Dawrea et al, 2018, the current results demonstrate the opposite effect (Fig. 3).…”

Section: Discussioncontrasting

confidence: 47%

“…In addition, treatment with arteetherlumefantrine-polymeric lyotropic liquid crystalline phase in-situ gel has been reported to cure mice of malaria infection and prolong their lifespan. However, the marketed arteether-treated group showed 100 % mortality within 20 days (Dawrea et al, 2018). Another study found that pluronic and hydroxy propyl methyl cellulose insitu gel is stable for over 90 days under different temperatures and humidity conditions.…”

Section: Discussionmentioning

confidence: 98%

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The Prophylactic Effect of Silver Sulphadiazine and Chloroquine in-situ Gel Formulation Against Rodent Malaria Parasite Plasmodium Berghei

Zelai

2021

Preprint

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Background: Despite the technological advances made in the pharmaceutical field, globally, malaria remains one of the major causes of mortality. The resistance of malaria parasites to conventional drugs is one of the primary challenges facing researchers. Therefore, the aim of this study is to examine the validity of a single dose in-situ gel formulation of chloroquine and silver sulfadiazine against rodent model malaria, Plasmodium berghei.Results: Following administration of the free or gel drug formulations to mice four days before infection, the in-situ gelled formulation were not found to improve drug parasitaemia nor increase the life span of the infected mice. This may be attributed to the initial high burst of drug release within the initial days of treatment before infection. Conclusions: Additional studies are warranted to determine the timing of the malarial drug burst, and to design the prophylactic interval based on the drug pharmacokinetics and their metabolites.

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 98%

The Prophylactic Effect of Silver Sulphadiazine and Chloroquine in-situ Gel Formulation Against Rodent Malaria Parasite Plasmodium Berghei

Zelai

2021

Preprint

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“…In this case, the hydrogels were loaded with CQ diphosphate and curcumin and their release mechanism was also appropriate as dual drug delivery systems. More recently, Dawre et al 121 formulated biodegradable hydrogels formed in situ taking advantage of the rapid phase transition of lyotropic liquid crystals in an environment that mimics intracellular conditions. A mixture of oleic acid, dibutyl sebacate and polysorbate 80 composed the lyotropic liquid crystalline preconcentrates, into which the antimalarials arteether and lumefantrine were dissolved.…”

Section: Polymeric Hydrogelsmentioning

confidence: 99%

Promising nanomaterials in the fight against malaria

et al. 2020

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“…A lyotropic liquid preconcentrate made up of polysorbate 80, oleic acid, and dibutyl-sebacate was made in which ACT derivatives like lumefantrine and artether were dissolved. Addition of PLGA to this solution helped to generated a 3-fold increase in the strength of the hydrogel, which showed sustained release . Density functionality theory (DFT) was used to study the theoretical interaction of three different antimalarial drugs (chloroquine, primaquine, and amodiaquine) with the hydrogel based acrylamide dimer and trimer molecules in both water and vacuum environments.…”

Section: Polymeric Nanocarrier Based Antimalarial Drug Delivery Systemsmentioning

confidence: 99%

Polymeric Nanoparticle Based Diagnosis and Nanomedicine for Treatment and Development of Vaccines for Cerebral Malaria: A Review on Recent Advancement

Patra

Singh

Wasnik

et al. 2021

ACS Appl. Bio Mater.

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Cerebral malaria occurs due to Plasmodium falciparum infection, which causes 228 million infections and 450,000 deaths worldwide every year. African people are mostly affected with nearly 91% cases, of which 86% are pregnant women and infants. India and Brazil are the other two countries severely suffering from malaria endemicity. Commonly used drugs have severe side effects, and unfortunately no suitable vaccine is available in the market today. In this line, this review is focused on polymeric nanomaterials and nanocapsules that can be used for the development of effective diagnostic strategies, nanomedicines, and vaccines in the management of cerebral malaria. Further, this review will help scientists and medical professionals by updating the status on the development stages of polymeric nanoparticle based diagnostics, nanomedicines, and vaccines and strategies to eradicate cerebral malaria. In addition to this, the predominant focus of this review is antimalarial agents based on polymer nanomedicines that are currently in the preclinical and clinical trial stages, and potential developments are suggested as well. This review further will have an important social and commercial impact worldwide for the development of polymeric nanomedicines and strategies for the treatment of cerebral malaria.

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Enhanced antimalalarial activity of a prolonged release in situ gel of arteether–lumefantrine in a murine model

Cited by 20 publications

References 28 publications

The Prophylactic Effect of Silver Sulphadiazine and Chloroquine in-situ Gel Formulation Against Rodent Malaria Parasite Plasmodium Berghei

The Prophylactic Effect of Silver Sulphadiazine and Chloroquine in-situ Gel Formulation Against Rodent Malaria Parasite Plasmodium Berghei

Promising nanomaterials in the fight against malaria

Polymeric Nanoparticle Based Diagnosis and Nanomedicine for Treatment and Development of Vaccines for Cerebral Malaria: A Review on Recent Advancement

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