Enhanced Antifungal Activity of Pure and Iron-Doped ZnO Nanoparticles Prepared in the Absence of Reducing Agents

Fathima, A. Ferin; Mani, R. Jothi; Sakthipandi, K.; Manimala, K.; Hossain, Aslam

doi:10.1007/s10904-019-01400-z

Cited by 48 publications

(12 citation statements)

References 44 publications

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“…The peaks related to ZnO NMs appeared at 2θ = 31.79° (100), 34.47° (002), 36.26° (101), 47.67° (102), 56.66° (110), 62.94° (103), 68.01° (112), 69.19° (201) and 77.04° (202), respectively. These peaks were in a good agreement with the diffraction patterns of JCPDS le no: 80 − 0075 corresponding to the hexagonal structure of ZnO NMs [12,41]. The XRD patterns of ZnO@PCD NPs showed no difference in comparison with the patterns of the ZnO NMs showing that structure of ZnO are retained in ZnO@PCD.…”

Section: Xrd Analysissupporting

confidence: 82%

Antibacterial performance of curcumin loaded polycyclodextrin-coated zinc oxide nanomaterials in photodynamic therapy against Enterococcus faecalis

Gholibegloo¹,

Akbari²,

Torshabi³

et al. 2022

Preprint

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Antimicrobial photodynamic therapy (aPDT) is a high potential strategy for the treatment of microbial infections in endodontics. In this study, a novel antibacterial agent was designed and prepared based on the two morphologies of zinc oxide nanomaterials (NMs) as ZnO nanosphere (ZnOS) and ZnO nanorod (ZnOR). Their surfaces were coated with carnosine (CAR)-functionalized polycyclodextrin (ZnO@PCD-CAR) for higher payload of curcumin (CUR) as a photosensitizer (PS). This system was characterized using FT-IR, XRD, TGA, FE-SEM, zeta potential analysis and UV-visible spectroscopy. The colony forming unit (CFU) assay was carried out to evaluate the antimicrobial properties of the nanoformulations againts Enterococcus faecalis (E. Faecalis). The target products (ZnOS@PCD-CAR/CUR and ZnOR@PCD-CAR/CUR) exhibited a light stability approximately by 2.9 and 2.8 fold, respectively, higher than the free CUR. Compared to the bare CUR, these materials indicated more stability againts pH variations. ZnOS@PCD-CAR/CUR and ZnOR@PCD-CAR/CUR NMs-mediated aPDT, significantly declined the count of E. Faecalis strains about 1.5 and 2 log (P < 0.05). Due to the high CUR loading, proper stability and significant inhibitory effects against E. Faecalis, ZnO@PCD-CAR/CUR could be considered as a promising antimicrobial agent in aPDT for efficient treatment of root canal infections.

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Section: Xrd Analysissupporting

confidence: 82%

Antibacterial performance of curcumin loaded polycyclodextrin-coated zinc oxide nanomaterials in photodynamic therapy against Enterococcus faecalis

Gholibegloo¹,

Akbari²,

Torshabi³

et al. 2022

Preprint

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“…Gold (III) chloride was purchased from Sigma-Aldrich (99.9% pure). The detailed procedure adopted to synthesis the ZnO nanoparticle was described in the earlier study [17].…”

Section: Methodsmentioning

confidence: 99%

“…The Antifungal activity of C-doped ZnO nanostructures against Rhizopus stolonifer fungus has improved when compared to the undoped ZnO nanoparticles [16]. The pure and Fe doped ZnO nanoparticles exhibit antifungal activity against Aspergillus niger, Aspergillus flavus and Rhizopus [17]. The effect and mode of action of iron-gold and cobalt-gold co-doped ZnO nanoparticles on the growth of such fungi have not yet been studied.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of Iron-gold and Cobalt-gold co-doped ZnO Nanoparticles

Fathima¹,

Mani

Sakthipandi

2021

Adv. Mater. Lett.

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“…Among the reactive oxygen species, hydrogen peroxide and hydroxyl radicals as the strong and nonselective ROSs can damage all types of biomolecules including carbohydrates, acids, lipids, proteins, DNA, RNA, and amino acids through inducing the oxidative stress [35]. [36].…”

Section: Antifungal Properties Of Nanostructuresmentioning

confidence: 99%

Antifungal effects of ZnO, TiO2 and ZnO-TiO2 nanocomposite on Aspergillus flavus

Ilkhechi¹,

Mozammel²,

Khoroushahi³

2020

Preprint

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This study aimed to synthesis ZnO, TiO2 and ZnO–TiO2 (ratio weight of 1/1 for Zn/Ti) nanoparticles using zinc acetate and titanium isopropoxide through the sol-gel method. Physicochemical and morphological characterization and antifungal properties evaluation like minimum inhibition concentration (MIC) and minimum fungicide concentration (MFC) of nanopowders were investigated against Aspergillus flavus at in vitro. All synthesized nanoparticles (50 µg/ml) showed fungal growth inhibition while ZnO-TiO2 showed higher antifungal activity against A. flavus than pure TiO2 and ZnO. TiO2 and ZnO-TiO2 (300 µg/ml) inhibited 100% of spur production. Pure ZnO and TiO2 showed pyramidal and spherical shapes, respectively whereas ZnO-TiO2 nanopowders illustrated both spherical and pyramidal shapes with grown particles on the surface. Based on our findings, low concentration (150 µg/ml) of ZnO-TiO2 showed higher ROS production and stress oxidative induction thus fungicide effect as compared to alone TiO2 and ZnO. In conclusion, ZnO-TiO2 nanostructure can be utilized as an effective antifungal compound but more studies need to be performed to understand the antifungal mechanism of the nanoparticles rather than ROS inducing apoptosis.

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Enhanced Antifungal Activity of Pure and Iron-Doped ZnO Nanoparticles Prepared in the Absence of Reducing Agents

Cited by 48 publications

References 44 publications

Antibacterial performance of curcumin loaded polycyclodextrin-coated zinc oxide nanomaterials in photodynamic therapy against Enterococcus faecalis

Antibacterial performance of curcumin loaded polycyclodextrin-coated zinc oxide nanomaterials in photodynamic therapy against Enterococcus faecalis

Antifungal Activity of Iron-gold and Cobalt-gold co-doped ZnO Nanoparticles

Antifungal effects of ZnO, TiO2 and ZnO-TiO2 nanocomposite on Aspergillus flavus

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