Enhanced anticancer activity <i>in vitro</i> and <i>in vivo</i> of luteolin incorporated into long-circulating micelles based on DSPE-PEG2000 and TPGS

Yan, Hongmei; Wei, Pingping; Song, Jie; Jia, Xiao‐Bin; Zhang, Zhenhai

doi:10.1111/jphp.12598

Cited by 30 publications

(20 citation statements)

References 41 publications

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“…The benzo(a)pyrene 50 mg/kg body weight given to mice caused elevation in lipid peroxide levels, markers of specific tumor to lungs such as carcinoembryonic antigen also called CEA and NSE or neuron‐specific enolase with an associated decrement both enzymatic antioxidants including superoxide dismutase, glutathione reductase catalase, glutathione‐s‐transferase, glutathione peroxidase, and nonenzymatic antioxidants, for example, reduced glutathione, vitamin C, and vitamin E. Luteolin treatment at 15 mg/kg body weight orally significantly offsets all these harmful alterations and thus maintained normalcy in cells. Besides, the treatment with luteolin was proposed to effectively negate benzo‐a‐pyrene‐induced enhanced regulation of the proliferating cell nuclear antigen expression, nuclear factor‐kappa B (NF‐κB), and cytochrome P450 1A1 was exposed by the evaluation of protein expression by Western bolt method (Han et al, ; Kasala, Bodduluru, Barua, & Gogoi, ; Yan, Wei, Song, Jia, & Zhang, )).…”

Section: Health Perspectives Of Tamarindmentioning

confidence: 99%

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RETRACTED: Tamarind: A diet‐based strategy against lifestyle maladies

Arshad

Imran

Ahmed

et al. 2019

Food Science & Nutrition

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The modern‐day review article is an exquisite attempt to demonstrate the extreme therapeutic potential of tamarind fruit (Tamarindus indica), particularly its pulp, seed, and leaf extract, against lifestyle‐related chronic disorders. The rapid transition in the diet patterns and also the varying lifestyle of the people has made its way forth, a momentous upsurge in a number of chronic as well as degenerative diseases. An excess of foods having functional and nutraceutical significance has come into view recently. These foods have emerged as effective therapeutical remedies against these disorders owing to their natural phytochemical constituents present in them, in abundance. Tamarindus indica serves as a proverbial herbal medicine in each and every part of the world that is known to mankind. Also, the tamarind kernel powder (TKP) is of immense commercial significance in some of the major, leading industries of the World. The derivation of an important gel‐forming substance (polysaccharide), named as “jellose,” from the decorticated seed kernels of tamarind fruit has led to the manufacture of pectin. It is used in industrial scale in the preparation of various products like jams, jellies, and most important in the preparation of cheese. It plays an evident role as a stabilizer of commercial significance, and it has also been greatly recommend by the scientists to be used as a potent ingredient in a range of pharmaceutical products. The leaves of tamarind plant are also used as part of the daily diet in several countries where they are readily consumed in fresh form and especially during drought season.

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Section: Health Perspectives Of Tamarindmentioning

confidence: 99%

“…(NF-κB), and cytochrome P450 1A1 was exposed by the evaluation of protein expression by Western bolt method (Han et al, 2016;Kasala, Bodduluru, Barua, & Gogoi, 2016;Yan, Wei, Song, Jia, & Zhang, 2016)).…”

Section: Anticancermentioning

confidence: 99%

RETRACTED: Tamarind: A diet‐based strategy against lifestyle maladies

Arshad

Imran

Ahmed

et al. 2019

Food Science & Nutrition

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“…EE is an important evaluation parameter for liposomes and is affected by the amount of PC, Chol, and DSPE-PEG 2000 in the liposomes [20][21][22][23][24] . Therefore, in this study, a three-level three-factor BBD was employed to optimize the formulation variables.…”

Section: Box-behnken Designmentioning

confidence: 99%

Preparation of PEGylated Liposomal Ginsenoside;Formulation Design and in vitro Evaluation

Cui¹,

Yang²,

Sun³

et al. 2020

ijps

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Cui et al.: Ginsenoside Rg3-loaded PEGylated liposomesIn this study, ginsenoside Rg3-loaded PEGylated liposomes were prepared and optimized using the Box-Behnken design. These liposomes were characterized, the cumulative release profiles were investigated and compared with ginsenoside Rg 3 -loaded liposomes in vitro. To improve the stability ginsenoside Rg3-loaded PEGylated liposomes were freeze-dried and the lyoprotectants to be added were screened. The results showed that the liposomes have a small particle size (152.58±0.74 nm) and spherical shape. The encapsulation efficiency and drug-loading rate were approximately 85.24±1.02 and 7.44±0.08 %, respectively. For lyoprotectants, 2 % lactose was chosen as the lyophilized protectant according to the appearance, re-dispersity, particle size, and entrapment efficiency of lyophilization of ginsenoside Rg3loaded PEGylated liposomes. In vitro release showed that ginsenoside Rg3-loaded PEGylated liposomes showed a more obvious sustained release effect, which suggests that ginsenoside Rg3-loaded PEGylated liposomes might enhance the therapeutic effect of ginsenoside Rg3.

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“…Among the various types of flavonoids, luteolin (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-chromenone) is a flavone in many substances, including celery, broccoli, green pepper, parsley and thyme (9). Several cellular and molecular biology studies have demonstrated that luteolin may possess anticancer activities (10,11).…”

Section: Introductionmentioning

confidence: 99%

Luteolin-induced apoptosis through activation of endoplasmic reticulum stress sensors in pheochromocytoma cells

Kwon

Kim

et al. 2017

Molecular Medicine Reports

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Luteolin [2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-chromenone] is an active flavonoid compound from Lonicera japonica (Caprifoliaceae). Luteolin inhibits tumor cell proliferation, inflammatory and oxidative stress better, when compared with other flavonoids. In the present study, it was demonstrated that luteolin induces typical apoptosis in PC12 cells (derived from a pheochromocytoma of the rat adrenal medulla) accompanied by DNA fragmentation and formation of apoptotic bodies. In addition, luteolin regulates expression of the endoplasmic reticulum (ER) chaperone binding immunoglobulin protein, activating ER stress sensors (eukaryotic initiation factor 2α phosphorylation and X‑box binding protein 1 mRNA splicing) and induced autophagy. The results indicated that luteolin induces the upregulation of the unfolded protein response pathway through the ER stress sensors, which helps as an influential regulator for the apoptosis pathway in PC12 cells. The results suggested that the understanding of the molecular mechanisms underlying luteolin‑induced apoptosis may be useful in cancer therapeutics, chemoprevention and neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.

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Enhanced anticancer activity in vitro and in vivo of luteolin incorporated into long-circulating micelles based on DSPE-PEG2000 and TPGS

Abstract: DTLLM might be a potential antitumour formulation.

Cited by 30 publications

References 41 publications

RETRACTED: Tamarind: A diet‐based strategy against lifestyle maladies

RETRACTED: Tamarind: A diet‐based strategy against lifestyle maladies

Preparation of PEGylated Liposomal Ginsenoside;Formulation Design and in vitro Evaluation

Luteolin-induced apoptosis through activation of endoplasmic reticulum stress sensors in pheochromocytoma cells

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