Enhanced antibacterial and wound healing activities of microporous chitosan-Ag/ZnO composite dressing

Lu, Zhong; Gao, Jingting; He, Qingfeng; Wu, Jie; Liang, Dan; Yang, Hao; Cheng, Gang

doi:10.1016/j.carbpol.2016.09.051

Cited by 315 publications

(121 citation statements)

References 39 publications

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“…More recently, metal nanomaterials had attracted the scientists' attention in the field of anti-infection because of their ability to overcome existing drug resistance at suitable doses, which can increase cellular uptake and reduce efflux of drugs from the microbial cell [1]. Zinc oxide nanoparticles (ZnONPs), which possess both antibacterial and anti-inflammatory properties and accelerate the healing of both acute and chronic wounds, are an ideal material for using in inhibiting growth of bacteria [2][3][4][5][6]. In addition, zinc is necessary for the human body as a trace element [7].…”

Section: Introductionmentioning

confidence: 99%

Zinc oxide/silver bimetallic nanoencapsulated in PVP/PCL nanofibres for improved antibacterial activity

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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The anti-infection ability and skin regeneration are important aspects on the progress of wound healing, which needs an ideal wound dressing that not only resists bacteria but also promotes skin regeneration. In this study, zinc oxide/silver/polyvinylpyrrolidone/polycaprolactone (ZnO/Ag/PVP/PCL) nanofibres were prepared through electrospinning. Firstly, zinc oxide nanoparticles (ZnONPs) and silver nanoparticle (AgNPs) were synthesized respectively. Secondly, the two nanoparticles were mixed with polyvinylpyrrolidone (PVP) and polycaprolactone (PCL) to obtain the nanofibres. The results of scanning electron microscopy (SEM) showed that ZnONPs and AgNPs were 40.07 ± 9.70 nm and 37.46 ± 12.02 nm, respectively. After electrospinning, the nanofibres were 368.22 ± 123.96 nm in diameter. Infrared spectroscopy revealed that ZnONPs/AgNPs bimetallic nanomaterials were physically embedded in the nanofibres. The antibacterial effects against Staphylococcus aureus and Escherichia coli of ZnO/Ag/PVP/PCL nanofibres were significantly better than these of the single metal material-loaded nanofibres. More importantly, the combination of ZnO and Ag reduced the cytotoxicity of ZnO/Ag/PVP/PCL bimetallic nanofibres toward fibroblasts. These findings demonstrated that ZnO/Ag/PVP/PCL bimetallic nanofibres should be of greater interest than the single metal nanomaterial-loaded nanofibres in inhibiting growth of bacteria.

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Section: Introductionmentioning

confidence: 99%

Zinc oxide/silver bimetallic nanoencapsulated in PVP/PCL nanofibres for improved antibacterial activity

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…Yüksek üçlü helezon yapısı içeriği olan jelatinin su içinde şişme özelliği de artmaktadır. Jelatin ve kitosan biyopolimeri birlikte kullanıldığında filmlerin fiziksel ve mekanik özellikleri iyileştirilebilmektedir [7,8].…”

Section: Gi̇ri̇ş (Introduction)unclassified

“…Bu çalışmada, yara örtücü olarak kullanılmak üzere polisakkarit esaslı kitosan biyopolimeri ile protein esaslı jelatin biyopolimerinin çeşitli oranlarda yara bölgesinde ekstrüdayı adsorplayarak yarayı steril tutacak, su buharı geçişine izin vererek yaranın hava almasını sağlayacak filmlerinin hazırlanması ve bu filmlerin yapısına yara iyileştirici ve antibakteryal özelliği ile bilinen sarı kantaron bitkisel ekstraktının eklenmesi ile filmlere antimikrobiyal özellik kazandırılması hedeflenmiştir. Literatürde kitosan ve jelatin içerikli yara örtücü filmler ve özelliklerine dair çalışmalar olmakla birlikte [7,8] sarı kantaronun kitosan ve jelatin biyopolimerleri ile bir arada kullanıldığı bir çalışmaya rastlanmamıştır.…”

Section: Gi̇ri̇ş (Introduction)unclassified

Sarı Kantaron (Hypericum perforatum) katkılı kitosan ve jelatin esaslı yara örtücü filmlerinin üretimi ve karakterizasyonu

Küçük

Yildirim

2019

Gazi Üniversitesi Mühendislik Mimarlık Fakültesi Dergisi

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Highlights:Graphical/Tabular Abstract  Preparation of chitosangelatin based wound dressing film  Incoporation of St.John's Worth to wound dressing film  Antibacterial effect of St.John's Worth Figure A. Preparation scheme for St.john's wort supported wound dressing filmsPurpose: The present study aimed to investigate the potential use of St.John's Wort (Hypericum perforatum) incorporated films based on chitosan and gelatin as wound dressing. Theory and Methods:Wound infections due to various organisms often lead to challenging complications for public health during wound care management and have been conducted many studies to develop new wound dressing materials which plays critical role in the healing process . A new, innovative wound dressing material still needs to be developed to overcome the current limitations by accompanying the unique features, such as promoted moist environment, rapid wound healing, mechanical protection, non-cytotoxic to healthy tissue, antimicrobial/antifungal effects. In this work, St. John's Wort (Hypericum perforatum) supported wound dressing films based on chitosan and gelatin were prepared by using solvent casting technique. As wound dressing film structures were confirmed by FTIR and optical microscope its physical properties such as thickness, mass, water vapor permission rate (WVPR), water absorption capacity, water content and dressing pH were determined. Also, antibacterial activities were determined by the agar disc diffusion method for gram positive (S. Aureus, B. Subtilis) and gram negative (S. Typhi, E. Coli) microorganisms. Results:St.John's Wort (Hypericum perforatum) incorporated films that are investigated for their potential as wound dressing films have water absorption capacities of 107-646%, water contents of 6.4-23.1% and water vapor permeability rate (WVPR) of 356.25-984.38 g/m2day respectively. Also, pH values of films were range of 5.26-7.66 and these values are suitable for wound dressing application. It has been observed that all films exhibit antibacterial activity by forming inhibition diameters against four different microorganisms. Conclusion:Material selection is an important step to design an ideal wound dressing. St.John's Wort (Hypericum perforatum) incorporated films based on chitosan and gelatin were successfully prepared using a sequential solvent casting method. The results obtained in this study showed that St.John's Wort incorporated films could be used as potential candidates for wound healing application

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“…The antibacterial activities and biocompatibility are critical for the wound healing applications . As shown in Figure D and Figure S3 in the Supporting Information, compared to GHK‐Cu monomers, the self‐assembled GHK‐Cu NPs showed obvious inhibition zones for both Escherichia coli ( E. coli) and Staphylococcus aureus ( S. aureus ).…”

mentioning

confidence: 99%

Self‐Assembled Fluorescent and Antibacterial GHK‐Cu Nanoparticles for Wound Healing Applications

Sun

et al. 2019

Part & Part Syst Charact

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GHK‐Cu is demonstrated with the abilities to improve wound healing, accelerate anti‐inflammatory activity, and repair DNA damage. However, the instability of the GHK‐Cu in biological fluids is always a big challenge for its long‐term and efficient function at the target site. Therefore, the self‐assembled GHK‐Cu nanoparticles (GHK‐Cu NPs) are investigated in this work to solve the instability issue. The crystalline nanostructure within the GHK‐Cu nanoparticles offers them visible and near‐infrared fluorescent properties. With the excellent self‐assembly performance, the antibacterial properties of GHK‐Cu NPs are demonstrated using E. coli and S. aureus. The L929 dermal fibroblast cells are utilized to prove the good biocompatibility and enhanced wound healing applications of GHK‐Cu NPs. This study could pave the way for the design and elaboration of a new class of fluorescent peptides with various biological functions in biomedical applications.

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Enhanced antibacterial and wound healing activities of microporous chitosan-Ag/ZnO composite dressing

Cited by 315 publications

References 39 publications

Zinc oxide/silver bimetallic nanoencapsulated in PVP/PCL nanofibres for improved antibacterial activity

Zinc oxide/silver bimetallic nanoencapsulated in PVP/PCL nanofibres for improved antibacterial activity

Sarı Kantaron (Hypericum perforatum) katkılı kitosan ve jelatin esaslı yara örtücü filmlerinin üretimi ve karakterizasyonu

Self‐Assembled Fluorescent and Antibacterial GHK‐Cu Nanoparticles for Wound Healing Applications

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