Enhanced antibacterial and antioxidant properties of chitosan-quercetin complex containing polycaprolactone microspheres for the treatment of gastroenteritis: An in-vitro and in-vivo analysis

Azeem, Muhammad; Hanif, Muhammad; Ameer, Nabeela; Ramzan, Nasreen; Abid, Usman; Latif, Hafsa; Chughtai, Fazal Rahman Sajid

doi:10.1016/j.mtcomm.2022.103780

Cited by 7 publications

(6 citation statements)

References 37 publications

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“…Our findings also show that the antimicrobial activity of quercetin incorporated into various types of nanoparticles against Gram-positive bacteria that cause impetigo is inversely related to the number of hydroxyl groups present in the B ring of these compounds, but is directly related to their lipophilicity. Thus, the effect of quercetin and Cu–Q complex-based nanoparticles on suggest that there is a tendency for higher inhibitory activity of Cu-Q-PCL-NPs due to their antioxidant activity . Stimulated skin cells appear to be the result of a combination of mechanisms .…”

Section: Resultsmentioning

confidence: 99%

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Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

et al. 2022

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The study aimed to improve the treatment of impetigo with naturally occurring quercetin and its copper–quercetin (Cu–Q) complex by preparing sustained-release (SR) nanoparticles of polycaprolactone (PCL). The solvent evaporation method was used for the copper–quercetin (Cu–Q) complex formation, and their PCL nanoparticles (PCL-NPs, Q-PCL-NPs, and Cu-Q-PCL-NPs) were prepared by the high-pressure homogenization method. Synthesis of nanoparticles was confirmed by their physicochemical and antibacterial properties of quercetin against Gram-positive as well as Gram-negative bacteria. The percentage loading efficiency of quercetin and release in 100 mM of phosphate buffer pH 7.4 and 5.5 at 37 °C was found to be more than 90% after 24 h with the zero-order release pattern. Minimum inhibitory concentration of nanoparticles was found to increase threefold in the case of Cu-Q-PCL-NPs may be due to the synergistic antibacterial behavior. Scanning electron microscopy showed spherical nanoparticles, and surface roughness was confirmed by atomic force microscopy analysis. Fortunately, no sign of irritation on rat skin even at 3%, was seen. In vitro antioxidant assay by 2,2-diphenyl-1-picrylhydrazyl reduction was found to be ≤80 ± 0.02% which confirmed their scavenging activity. Interestingly, for the ex vivo study, the tape-stripping model was applied against Staphylococcus aureus containing rats and showed the formation of the epidermal layer within 4–5 days. Confirmation of antibacterial activity of pure quercetin, from Cu–Q complex, and their SR release from Q-PCL-NPs and Cu-Q-PCL-NPs was considered an effective tool for the treatment of skin diseases and can be used as an alternative of already resistant ciprofloxacin in impetigo.

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Section: Resultsmentioning

confidence: 99%

“…Thus, the effect of quercetin and Cu−Q complex-based nanoparticles on suggest that there is a tendency for higher inhibitory activity of Cu-Q-PCL-NPs due to their antioxidant activity. 41 Stimulated skin cells appear to be the result of a combination of mechanisms. 42 These observations.…”

Section: Encapsulation Efficiency (% Ee)mentioning

confidence: 99%

Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

et al. 2022

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“…Glyceryl Behenate Showed significantly superior effectiveness (Chakraborty et al, 2017) ; compared to conventional antihistamine (Rosita et al, 2022) ; medications; spherical with smooth surfaces, (Hariyadi et al, 2022) demonstrated good flowability; prolonging quercetin release duration Chitosan-Promising potential for wound dressings and (Zhou et al, 2021) ; Polycaprolactone medication delivery carriers in wound management; (Azeem et al, 2022) ; synergistic antibacterial and antioxidant capabilities (Viscusi et al, 2023) have a 30-month shelf life; the delayed release of quercetin in an acidic environment Chitosan Superior therapeutic effects in rabbit colitis models; (Helmy et al, 2020) ; effective approach for developing antibiotic (Wiggers et al, 2022) ; -releasing coatings for medical purposes; the (Azeem et al, 2023) bactericidal activity has been improved.…”

Section: Inulin-chitosanmentioning

confidence: 99%

“…Hot-melt extrusion (Khor et al, 2017) Chitosan-Fluorescein Oxidative degradation and ionic (Zhou et al, 2022) ; Isothiocyanate-Zein cross-linking; coacervation (Al-Musawi et al, 2023) ; (Elmowafy et al, 2023) Sodium Alginate Aerosolization ionic gelation (Kalalo et al, 2022) ; (Xu et al, 2023) ; (Szulc Musioł et al, 2023) Inulin-Chitosan-Emulsion-assisted gelation, ionic gelation (Nalini et al, 2019) ; Sodium Alginate (Liu et al, 2022) ; (Liu et al, 2023) Glyceryl Behenate Emulsification (Chakraborty et al, 2017) ; (Rosita et al, 2022) ; (Hariyadi et al, 2022) Chitosan-Polycaprolactone Ultra-homogenization (Zhou et al, 2021) ; (Azeem et al, 2022) ; (Viscusi et al, 2023) Chitosan Ionic cross-linking (Helmy et al, 2020) ; (Wiggers et al, 2022) ; (Azeem et al, 2023) Chitosan-Alumina-Double oil in water emulsification; (Liu et al, 2017) ; PLGA-Oleic Acid gelation ionic and spray drying (Lee et al, 2018) ; (Nematollahi et al, 2021) Alginate-Hydroxyapatite Gelation method; electrostatic (Malvano et al, 2021) ; microencapsulation (Kim et al, 2022) ; (Montone et al, 2023) Eudragit S100…”

Section: Starchmentioning

confidence: 99%

“…Stability experiments indicated a 30-month shelf life for the CS-QT-PCL-Levo-Ms complex. The microsphere-shaped CS-QT complex, which possesses synergistic antibacterial and antioxidant capabilities, can serve as a viable substitute for currently available antibiotics in the treatment of gastroenteritis (Azeem et al, 2022) . Quercetin was gradually released, promoting wound healing and prolonged bacteriostasis.…”

Section: Polycaprolactonementioning

confidence: 99%

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Quercetin in Drug Carriers: Polymer Composite, Physical Characteristics, and In vitro Study

Kurniawan,

Setyawan,

Hariyadi

2024

Sci. Technol. Indones

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Quercetin is a highly prevalent flavonoid commonly found in a wide variety of fruits and vegetables. This compound has various biological actions, indicating great potential in preventing diseases and promoting health but the disadvantages include low solubility and instability. The disadvantages can be overcome by using a polymer composite in the form of microspheres in the formulation. Therefore, this study aimed to review various uses of polymers in delivering quercetin compounds. The results showed that various polymers in microspheres have been formulated with quercetin to minimize the weaknesses. The delivery systems developed and reported from several related studies include microencapsulation, microcapsules, microparticles, microspheres, solid lipid microparticles (SLM), and nanoparticles. Polymers including Gelatine, Maltodextrin and Inulin, Carnauba wax, Poly (lactic-co-glycolic acid (PLGA), Gyceryl behenate, Pectin, Nano-hydroxyapatite, Polycaprolactone, Starch, Chitosan, Eudragit S 100, Sodium Alginate, Ethyl cellulose, and Alumina efficiently improved the properties of quercetin, enabling the utilization as a controlled drug delivery agent. Therefore, developing a quercetin delivery system using composite polymers presents both an opportunity and a challenge for future applications.

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Biological evaluation, GC–MS profiling, and molecular docking studies of some essential oils against postharvest pathogens of maize

Shabir,

Aftab,

Tehmina

et al. 2023

Arabian Journal of Chemistry

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Enhanced antibacterial and antioxidant properties of chitosan-quercetin complex containing polycaprolactone microspheres for the treatment of gastroenteritis: An in-vitro and in-vivo analysis

Cited by 7 publications

References 37 publications

Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

Concomitant Effect of Quercetin and Its Copper Complex in the Development of Sustained-Release Nanoparticles of Polycaprolactone, Used for the Treatment of Skin Infection

Quercetin in Drug Carriers: Polymer Composite, Physical Characteristics, and In vitro Study

Biological evaluation, GC–MS profiling, and molecular docking studies of some essential oils against postharvest pathogens of maize

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