Enhanced Antibacterial Activity of Vancomycin Loaded on Functionalized Polyketones
Rachele Rampazzo,
Andrea Vavasori,
Lucio Ronchin
et al.
Abstract:Today, polymeric Drug Delivery Systems (DDS) appear as an interesting solution against bacterial resistance, having great advantages such as low toxicity, biocompatibility, and biodegradability. In this work, two polyketones (PK) have been post-functionalized with taurinate (PKT) or sulfanilate (PKSK) and employed as biocompatible carriers for Vancomycin against bacterial infections. Mod-ified PKs were easily prepared by Paal-Knorr reaction and loaded with Vancomycin at variable pH. All polymers were character… Show more
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