Enhanced anti-tumor effect of pH-responsive dextrin nanogels delivering doxorubicin on colorectal cancer

Manchun, Somkamol; Dass, Crispin R.; Cheewatanakornkool, Kamonrak; Sriamornsak, Pornsak

doi:10.1016/j.carbpol.2015.03.018

Cited by 72 publications

(33 citation statements)

References 52 publications

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“…40,41 It is known that dextrin backbone modification and/or the degree of such modifications can affect the biodegradability of the dextrin. 52,56 Das et al 46 synthesized and characterized a biodegradable crosslinked HG, consisting of polylactic acid (PLA) and dextrin in the presence of crosslinker N,Nmethylenebisacrylamide-Dxt-g-PLA HG. However, in vivo toxicity studies are scarce and focus mainly local degradation and inflammatory response in subcutaneous assays, 22,42 or in vivo drug release studies for nanogels.…”

Section: Discussionmentioning

confidence: 99%

“…40,41 It is known that dextrin backbone modification and/or the degree of such modifications can affect the biodegradability of the dextrin. 35,42,43 During the last years, few researchers have successfully developed and characterized dextrin-based HGs 20,44-49 and nanogels 34,[50][51][52][53][54][55] for drug delivery and tissue engineering applications. However, in vivo toxicity studies are scarce and focus mainly local degradation and inflammatory response in subcutaneous assays, 22,42 or in vivo drug release studies for nanogels.…”

Section: Discussionmentioning

confidence: 99%

“…However, in vivo toxicity studies are scarce and focus mainly local degradation and inflammatory response in subcutaneous assays, 22,42 or in vivo drug release studies for nanogels. 52,56 Das et al 46 synthesized and characterized a biodegradable crosslinked HG, consisting of polylactic acid (PLA) and dextrin in the presence of crosslinker N,Nmethylenebisacrylamide-Dxt-g-PLA HG. The acute toxicity of the Dxt-g-PLA HG was assessed in mice after a single orally administered dose of HG (2000 mg/kg body weight), and no mortality was observed within 12 weeks.…”

Section: Discussionmentioning

confidence: 99%

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In vivo systemic toxicity assessment of an oxidized dextrin‐based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes

Pereira

Fraga

Maltez

et al. 2019

J Biomedical Materials Res

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The worldwide incidence of bone disorders is raising, mainly due to aging population. The lack of effective treatments is pushing the development of synthetic bone substitutes (SBSs). Most ceramic‐based SBSs commercially available display limited handling properties. Attempting to solve these issues and achieve wider acceptance by the clinicians, granular ceramics have been associated with hydrogels (HGs) to produce injectable/moldable SBSs. Dextrin, a low‐molecular‐weight carbohydrate, was used to develop a fully resorbable and injectable HG. It was first oxidized with sodium periodate and then cross‐linked with adipic acid dihydrazide. The in vivo biocompatibility and safety of the dextrin‐based HG was assessed by subacute systemic toxicity and skin sensitization tests, using rodent models. The results showed that the HG did not induce any systemic toxic effect, skin reaction, or genotoxicity, neither impaired the bone repair/regeneration process. Then, the HG was successfully combined with granular bone substitute, registered as Bonelike (250–500 μm) to obtain a moldable/injectable SBS, which was implanted in tibial fractures in goats for 3 and 6 weeks. The obtained results showed that HG allowed the stabilization of the granules into the defect, ensuring effective handling, and molding properties of the formulation, as well as an efficient cohesion of the granules. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1678–1689, 2019.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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In vivo systemic toxicity assessment of an oxidized dextrin‐based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes

Pereira

Fraga

Maltez

et al. 2019

J Biomedical Materials Res

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“…The DOX-loaded dextrin nanogel could significantly reduce DOX toxicitytowards normal cells, which reduces the side effects. [128] Similar to dextran and chitosan, HA was chemically modified with 5-b-cholanic acid to form nanoparticles ranging in size between 200-400nm, and showed more specifict argeting of passivet umorse xpressing CD44. [129] HA, if conjugated with poly(g-benzyl l-glutamate)-block, forms amphiphilic block copolymers.…”

Section: Entrapment Of Drugs In Hydrogels and Aerogel Matricesmentioning

confidence: 99%

Biodegradable Polysaccharides for Controlled Drug Delivery

et al. 2016

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Polysaccharides are ideal candidates for drug delivery and biomedical applications as they are easily obtained from natural sources. Furthermore, they can be subjected to a wide range of chemical and enzymatic reactions, they have biocompatible and biodegradable properties and have inherently low immunogenicity. Polysaccharides are potentially the materials of choice for the development of “smart” delivery systems, which are capable of releasing, at the appropriate time and site of action, an encapsulated drug. This Review examines various aspects of the crosslinking of polysaccharides, either for a single polysaccharide or mixtures, and also natural–synthetic hybrids. The Review focuses on the strategies for using these biodegradable polymers for controlled drug delivery, and examines in particular polysaccharide–drug conjugates, the encapsulation of drugs in hydrogels and aerogels, and the self‐assembly of polysaccharide drug‐loaded nanoparticles.

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“…The anticancer effect of DRTN was compared to that of hydrogel and irinotecan solution in the tumor-bearing mice, respectively Manchun et al, 2015).…”

Section: In Vivo Evaluation In Tumor Xenograft Athymic Nude Micementioning

confidence: 99%

Irinotecan-encapsulated double-reverse thermosensitive nanocarrier system for rectal administration

et al. 2017

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Republic of Korea AbstractIntravenously administered for the treatment of rectum cancer, irinotecan produces severe side effects due to very high plasma concentrations. A novel irinotecan-encapsulated double reverse thermosensitive nanocarrier system (DRTN) for rectal administration was developed as an alternative. The DRTN was fabricated by dispersing the thermosensitive irinotecanencapsulated solid lipid nanoparticles (SLN) in the thermosensitive poloxamer solution. Its gel properties, pharmacokinetics, morphology, anticancer activity and immunohistopathology were assessed after its rectal administration to rats and tumor-bearing mice. In the DRTN, the solid form of the SLN and the liquid form of the poloxamer solution persisted at 25 C; the former melted to liquid, and the latter altered to gel at 36.5 C. The DRTN was easily administered to the anus, gelling rapidly and strongly after rectal administration. Compared to the conventional hydrogel and intravenously administered solution, it retarded dissolution and initial plasma concentration. The DRTN gave sustained release and nearly constant plasma concentrations of irinotecan at 1-3 h in rats, resulting in improved anticancer activity. It induced no damage to the rat rectum and no body weight loss in tumor-bearing mice. Thus, this irinotecan-encapsulated DRTN associated with a reduced burst effect, lack of toxicity and excellent antitumor efficacy would be strongly recommended as a rectal pharmaceutical product alternative to commercial intravenous injection in the treatment of rectum and colon cancer. KeywordsIrinotecan, double reverse thermosensitive nanocarrier, rectal administration, burst effect, toxicity, anti-tumor efficacy History

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Enhanced anti-tumor effect of pH-responsive dextrin nanogels delivering doxorubicin on colorectal cancer

Cited by 72 publications

References 52 publications

In vivo systemic toxicity assessment of an oxidized dextrin‐based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes

In vivo systemic toxicity assessment of an oxidized dextrin‐based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes

Biodegradable Polysaccharides for Controlled Drug Delivery

Irinotecan-encapsulated double-reverse thermosensitive nanocarrier system for rectal administration

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