Enhanced Anti-Cancer Capability of Ellagic Acid Using Solid Lipid Nanoparticles (SLNs)

Taheri, Ramezan Ali; Hamishehkar, Hamed; Rahmati-Yamchi, Mohammad; Shanehbandi, Dariush; Ahmad, Saeed Nazari Soltan; Hasani, Akbar

doi:10.5812/ijcm.9402

Cited by 26 publications

(12 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides the initial burst release of drug which usually occurs represent an additional concern with these formulations [88]. These systems were proposed as carriers for improving the anticancer activity of EA against prostate cancer by Hajipour et al [89]. EA-loaded SLNs were prepared by the homogenization method as follows.…”

Section: Functionalized Graphene Oxide (Go) Carriersmentioning

confidence: 99%

Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid

et al. 2020

View full text Add to dashboard Cite

Ellagic acid, a polyphenolic compound present in fruit and berries, has recently been the object of extensive research for its antioxidant activity, which might be useful for the prevention and treatment of cancer, cardiovascular pathologies, and neurodegenerative disorders. Its protective role justifies numerous attempts to include it in functional food preparations and in dietary supplements, and not only to limit the unpleasant collateral effects of chemotherapy. However, ellagic acid use as a chemopreventive agent has been debated because of its poor bioavailability associated with low solubility, limited permeability, first pass effect, and interindividual variability in gut microbial transformations. To overcome these drawbacks, various strategies for oral administration including solid dispersions, micro and nanoparticles, inclusion complexes, self-emulsifying systems, and polymorphs were proposed. Here, we listed an updated description of pursued micro and nanotechnological approaches focusing on the fabrication processes and the features of the obtained products, as well as on the positive results yielded by in vitro and in vivo studies in comparison to the raw material. The micro and nanosized formulations here described might be exploited for pharmaceutical delivery of this active, as well as for the production of nutritional supplements or for the enrichment of novel foods.

show abstract

Section: Functionalized Graphene Oxide (Go) Carriersmentioning

confidence: 99%

Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Found in many fruits (especially pomegranates, raspberries, blueberries, strawberries, walnuts, and grapes) (Hajipour et al., 2018), ellagic acid (EA) is a type of antioxidant that is naturally occurring and widely used for cancer treatment (Verotta et al., 2018). Recent studies have described EA as a naturally occurring bioactive polyphenolic substance (Mady & Shaker, 2017).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of ellagic acid from pomegranate peels in microalgae optimized by response surface methodology and an investigation of its controlled released under simulated gastrointestinal studies

Yağmur¹,

Şahin

2020

Journal of Food Science

View full text Add to dashboard Cite

Ellagic acid (EA), a naturally occurring bioactive phenolic compound largely found in pomegranate, exhibits significant health benefits due to its antioxidant, antimutagenic, and even anticancerogenic properties. The present work aimed to microencapsulate EA extracted from pomegranate peels. To improve the stability of EA, microencapsulation was applied with Spirulina as a coating material. For this purpose, ethanolic extracts obtained from pomegranate peels were used for microencapsulation. Response surface methodology combined with a three-level, three-variable Box-Behnken design (BBD) was applied to obtain optimum microencapsulation. The microparticles obtained under the optimized encapsulation conditions were further characterized by FT-IR and SEM. The results confirmed the encapsulation of EA in Spirulina cells. Then, the optimum microparticles were used in an in vitro release study. The results of the in vitro digestion with simulated gastrointestinal fluids could help to determine the content and biological activity of EA. In this study, the effect of encapsulation on the release properties of EA during simulated gastrointestinal digestion was also evaluated. HPLC-DAD analysis and the Folin-Ciocalteu and ABTS methods were helpful for characterization of EA in the simulated fluids. The release profile of EA indicated that in simulated intestinal fluid, the release was faster than that in gastric fluid.Practical Application: This study describes the microencapsulation of ethanolic extracts of pomegranate peel (PP) in Spirulina. This application has been performed to improve the stability and bioavailability of EA in the extracts. Optimum microencapsulation was obtained by response surface methodology with BBD. After the characterization of the obtained optimum Spirulina/EA mixture by FT-IR and SEM, an in vitro release study was conducted for stability research. The results will guide other researchers working on the determination of the content and biological activity of EA and on optimizing the microencapsulation process.

show abstract

“…A typical BAC engineered by nanotechnology is EA, a polyphenol found in fruits and vegetables, whose several healthy properties are unfortunately associated with very poor solubility and numerous pharmacokinetic drawbacks. Several studies exist on the adoption of appropriate NPs-based devices to enhance EA solubility, its hydrophilic-lipophilic balance (HLB), and GIT absorbability, as well as to protect it from early metabolism [ 14 , 51 , 52 , 53 , 54 , 55 , 56 ]. In particular, high water solubility was achieved using cyclodextrins [ 54 , 55 ], pectin, and polyester-based dendrimers [ 56 ].…”

Section: Nanotechnology Nano-formulations and Nanomaterialsmentioning

confidence: 99%

Nanotechnological Manipulation of Nutraceuticals and Phytochemicals for Healthy Purposes: Established Advantages vs. Still Undefined Risks

2021

View full text Add to dashboard Cite

Numerous foods, plants, and their bioactive constituents (BACs), named nutraceuticals and phytochemicals by experts, have shown many beneficial effects including antifungal, antiviral, anti-inflammatory, antibacterial, antiulcer, anti-cholesterol, hypoglycemic, immunomodulatory, and antioxidant activities. Producers, consumers, and the market of food- and plant-related compounds are increasingly attracted by health-promoting foods and plants, thus requiring a wider and more fruitful exploitation of the healthy properties of their BACs. The demand for new BACs and for the development of novel functional foods and BACs-based food additives is pressing from various sectors. Unfortunately, low stability, poor water solubility, opsonization, and fast metabolism in vivo hinder the effective exploitation of the potential of BACs. To overcome these issues, researchers have engineered nanomaterials, obtaining food-grade delivery systems, and edible food- and plant-related nanoparticles (NPs) acting as color, flavor, and preservative additives and natural therapeutics. Here, we have reviewed the nanotechnological transformations of several BACs implemented to increase their bioavailability, to mask any unpleasant taste and flavors, to be included as active ingredients in food or food packaging, to improve food appearance, quality, and resistance to deterioration due to storage. The pending issue regarding the possible toxic effect of NPs, whose knowledge is still limited, has also been discussed.

show abstract

Enhanced Anti-Cancer Capability of Ellagic Acid Using Solid Lipid Nanoparticles (SLNs)

Cited by 26 publications

References 31 publications

Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid

Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid

Encapsulation of ellagic acid from pomegranate peels in microalgae optimized by response surface methodology and an investigation of its controlled released under simulated gastrointestinal studies

Nanotechnological Manipulation of Nutraceuticals and Phytochemicals for Healthy Purposes: Established Advantages vs. Still Undefined Risks

Contact Info

Product

Resources

About