Enhanced analgesic activity by cyclodextrins – a systematic review and meta-analysis

Brito, Renan Guedes de; Araújo, Adriano A. S.; Quintans, Jullyana S. S.; Sluka, Kathleen A.; Quintans‐Júnior, Lucindo J.

doi:10.1517/17425247.2015.1046835

Cited by 53 publications

(21 citation statements)

References 78 publications

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“…Clinical and preclinical evidence has shown that the pharmacological effects of analgesic and anti-inflammatory drugs are improved when complexed with CDs [76][77][78].…”

Section: Discussion Of Unusual Topics In Fibromyalgiamentioning

confidence: 99%

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Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Brito¹,

Santos²,

AlmeidaOliveira³

et al. 2018

Discussions of Unusual Topics in Fibromyalgia

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Fibromyalgia (FM) is the second most common rheumatologic disorder, affecting 5% of the world population, and has a serious effect on the quality of life of patients, as well as an economic impact through lost workdays. This pain syndrome is a common cause of chronic widespread pain and is characterized by reduced pressure pain thresholds with hyperalgesia and allodynia, nonrestorative sleep, fatigue, cognitive dysfunction, and mood disturbances. The pharmacological treatment strategies for FM include the use of antidepressants, calcium channel modulators, muscle relaxants, and analgesics but have shown limited efficacy and therapeutic adherence. Thus, researchers have been seeking potential substances (new chemical entities or through drug repositioning) that could be used for FM treatment. In this context, natural products (NPs) have been shown to be promising pharmacological tools due to the variety of their pharmacological activity and the number of molecular sites available as possible active targets. Recent clinical and preclinical studies have been conducted to verify the possible applicability of NPs such as essential oils (EOs), plants extracts, terpenes, sapogenins, and alkaloids in the treatment of FM. The results have shown that natural products have an analgesic effect in different animal models of FM, probably by activation of inhibitory descending pathways, such as the periaqueductal gray and rostroventromedial medulla. Natural products and their secondary metabolites could therefore be a promising source for FM management. However, translational studies that seek to validate the preclinical studies are scarce, incipient, and lacking an approach focused on the traditional pharmaceutical market.

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“…Clinical and preclinical evidence has shown that the pharmacological effects of analgesic and anti-inflammatory drugs are improved when complexed with CDs [76][77][78].…”

Section: Discussion Of Unusual Topics In Fibromyalgiamentioning

confidence: 99%

“…Another study, also using the chronic noninflammatory widespread pain model in mice (an FM animal model), evaluated the effect of α-terpineol (Figure 4), both pure and complexed in β-CD, as CDs are useful tools in improving the pharmacological properties of terpenes [77,80].…”

Section: Discussion Of Unusual Topics In Fibromyalgiamentioning

confidence: 99%

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Brito¹,

Santos²,

AlmeidaOliveira³

et al. 2018

Discussions of Unusual Topics in Fibromyalgia

View full text Add to dashboard Cite

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“…Thus, the physicochemical properties of the drug (e.g., its solubility in water), the composition of the drug's formulation (e.g., aqueous or non-aqueous), and the physiological composition of the membrane barrier (e.g., the presence of an aqueous diffusion layer), will determine whether the CDs will enhance or will hamper the drug's delivery through a biological membrane (Loftsson, Masson & Brewster, 2004). This seems to be quite advantageous for natural non-polar compounds such as terpenes (Brito, Araujo, Quintans, Sluka & Quintans-Junior, 2015;Marques, 2010a;Pinho, Grootveld, Soares & Henriques, 2014a;Quintans et al, 2013b).…”

Section: Inclusion Methods and Complexation Efficiencymentioning

confidence: 99%

“…The formation of inclusion complexes increases the guest's in vivo stability against hydrolysis, oxidation, decomposition, and dehydration, as well as increasing their bioavailability (Brito, Araujo, Quintans, Sluka & Quintans-Junior, 2015;Oliveira, Guimaraes, Araujo, Quintans, Santos & Quintans-Junior, 2015;Loftsson & Duchene, 2007).…”

Section: Cyclodextrins (Cds)mentioning

confidence: 99%

Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches

Lima

Lucchese

Araújo-Filho

et al. 2016

Carbohydrate Polymers

134

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“…These preclinical studies also showed greater bioavailability of the drug with reduced side effects. [15] Since ancient times, honey was valued as a flavorful sweetener. It also has an extensive history of traditional medicinal use.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Shaikh¹

2017

IJGP

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Aim: The aim of this study was to check the effect of solubility enhancement and use of honey on anti-inflammatory and antibacterial activity of etodolac (ETO). Materials and Methods: Ternary system of ETO was prepared using polyvinylpyrrolidone K30 (PVP K30) and hydroxypropyl β-cyclodextrin (HPB) by spray drying method. Design of experiment was used for preparation and optimization of ternary system. Formulations were prepared with and without addition of honey and were evaluated for its anti-inflammatory and antibacterial activity. Antiinflammatory activity was evaluated using human red blood cell (HRBC) membrane stabilization and protein denaturation methods. Disc diffusion and well diffusion methods were used to determine antibacterial activity of prepared formulations. Results and Discussion: In HRBC membrane stabilization and protein denaturation method, the prepared ternary system formulations (without honey) achieved up to 83.3% and 83.4% inhibition; whereas, the pure sample of ETO had 58.1% and 57.8% inhibition, respectively. The antimicrobial activity was significantly affected by the type of bacteria used. In well diffusion method, run 8 showed the highest inhibitory activity of 35 ± 1.3 mm and 25 ± 1.2 mm (with honey) and 30 ± 1.1 mm and 18 ± 1.0 mm (without honey) against Bacillus subtilis and Escherichia coli, respectively. Addition of honey played a significant role in increasing the anti-inflammatory as well as antibacterial activity of all formulations. Conclusion: Use of PVP K30 and HPB in combination with honey was an effective approach to enhance the anti-inflammatory and antibacterial activity of ETO.

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Enhanced analgesic activity by cyclodextrins – a systematic review and meta-analysis

Abstract: The use of cyclodextrins can improve the efficacy of analgesic compounds, and they are an important tool in the search for greater analgesic effect. They may also be a way to reduce the therapeutic doses, and hence increasing the potential of the drug.

Cited by 53 publications

References 78 publications

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Natural Products as Promising Pharmacological Tools for the Management of Fibromyalgia Symptoms – A Review

Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches

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