Enhanced Acute Ocular Hypotensive Response to Timolol with Dexamethasone Treatment

Rom, Michael E.; Schwartz, Bernard; Bealka, Neal

doi:10.1097/00061198-199704000-00007

Cited by 2 publications

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“…Similarly, in human eyes, an enhanced ocular hypotensive response occurs with 0.01% dexamethasone phosphate drops and 0.01% timolol maleate drops (10). Rabbit experiments also show the enhanced hypotensive response to timolol with dexamethasone drops (11).…”

Section: Discussionmentioning

confidence: 91%

Dose Response of Dexamethasone for the Enhanced Ocular Hypotensive Response to Epinephrine in Rabbits With Prior Dexamethasone Treatment

Schwartz

Rom²,

Bealka³

et al. 2002

Journal of Ocular Pharmacology and Therapeutics

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We have previously shown that administration of epinephrine to the rabbit eye with dexamethasone pretreatment resulted in a significant decrease in intraocular pressure (IOP), compared to the use of epinephrine alone. Furthermore, this decrease in IOP is dose-dependent on epinephrine with the largest response of decrease of IOP occurring at the lower doses of epinephrine. We now extend this study to determine whether the decrease in IOP is dose-dependent on dexamethasone. Rabbit eyes were pretreated with five applications of topical dexamethasone or saline, administered at fifteen-minute intervals. Eyes were then treated with 0.005% epinephrine (0.01% epinephrine bitartrate). IOP was monitored for the next four hours. Different groups of rabbits received varying concentrations of dexamethasone base, from 0.0004% to 0.07% (dexamethasone phosphate), and a dose response curve was obtained. When compared to eyes treated with epinephrine alone, eyes pretreated with dexamethasone showed a significantly greater decrease in pressure at free base dexamethasone concentrations of 0.07%, 0.007% and 0.0007%, with the greatest difference at the 0.007% concentration (mean = 6.8 mm Hg). Similarly, the duration taken for the IOP to return to baseline levels was prolonged in the groups receiving dexamethasone pretreatment. The synergism between dexamethasone and epinephrine in lowering IOP may be a useful alternative in the treatment of ocular hypertension and glaucoma especially using a combination of a low dose of epinephrine with a low dose of dexamethasone.

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Section: Discussionmentioning

confidence: 91%

Dose Response of Dexamethasone for the Enhanced Ocular Hypotensive Response to Epinephrine in Rabbits With Prior Dexamethasone Treatment

Schwartz

Rom²,

Bealka³

et al. 2002

Journal of Ocular Pharmacology and Therapeutics

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Enhanced Ocular Hypotensive Response to Timolol in Rabbits with Prior Dexamethasone Treatment

Schwartz

Rom²

2001

Journal of Ocular Pharmacology and Therapeutics

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The purpose of this study was to determine glucocorticoid modulation of ocular pressure to timolol applied topically to rabbit eyes that were pretreated with dexamethasone. Rabbits were pretreated with five applications of topical 0.007% of dexamethasone (0.01% dexamethasone phosphate) or saline drops, administered at ten min intervals. The eyes were then treated with timolol maleate drops at concentrations of free base of 0.00007%, 0.0007%, 0.007% and 0.07%. An additional group of rabbits received dexamethasone pre-treatment only. Intraocular pressure was measured for the next four hr. Enhanced lowering of intraocular pressure was observed with dexamethasone pretreatment. Rabbits receiving the smaller dose of timolol had the least decrease in pressure. The most significant decreases in pressures occurred at 45 min after the administration of timolol with an average difference of 4.8 mm Hg between the timolol- and dexamethasone/timolol-treated eyes for the three largest concentrations of timolol. This synergism between glucocorticoids and beta-adrenergic blockers in lowering IOP may be potentially useful in the therapy of ocular hypertension and glaucoma.

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Enhanced Acute Ocular Hypotensive Response to Timolol with Dexamethasone Treatment

Cited by 2 publications

References 0 publications

Dose Response of Dexamethasone for the Enhanced Ocular Hypotensive Response to Epinephrine in Rabbits With Prior Dexamethasone Treatment

Dose Response of Dexamethasone for the Enhanced Ocular Hypotensive Response to Epinephrine in Rabbits With Prior Dexamethasone Treatment

Enhanced Ocular Hypotensive Response to Timolol in Rabbits with Prior Dexamethasone Treatment

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