Enhanced acquisition of cocaine self-administration in adult rats with neonatal isolation stress experience

Kosten, Therese A.; Miserendino, Mindy J.D.; Kehoe, Priscilla

doi:10.1016/s0006-8993(00)02595-6

Cited by 180 publications

(142 citation statements)

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“…We have consistently shown that baseline activity levels do not differ between ISO and NH rats (Kehoe et al, 1996(Kehoe et al, , 1998bKosten et al, 2000Kosten et al, , 2004Kosten et al, , 2005a. There are also no group differences in inactive lever press responses in the self-administration study and no differences in baseline response rates in the food study.…”

Section: Discussionmentioning

confidence: 50%

“…Further, early life stress may also enhance other appetitive behaviors in women based on our finding that ISO enhances responding for food under a condition thought to reflect motivation to work for reinforcement. Indeed, that ISO enhances responding for food in female rats, but not male rats (Kosten et al, 2000(Kosten et al, , 2004Zhang et al, 2005), may provide an insight into the role of early life stress on gender differences in vulnerability to develop eating disorders (Seeman, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Standard operant chambers (Coulbourn Instruments, Allentown, PA) were housed in ventilated, soundattenuating cubicles (Coulbourn Instruments) with fans to mask outside noise. On one wall of each chamber, there were two response levers and above each were three 'cue' lights, as described previously (Kosten et al, 2000(Kosten et al, , 2004. Minimal downward pressure (about 25 g) on a lever could result in a programmed response.…”

Section: General Methodsmentioning

confidence: 99%

“…Under ketamine (10 mg/kg) and xylazine HCl (0.2 mg/kg) anesthesia (i.p. ), rats were implanted with chronically indwelling catheters, made of Silastic tubing, into the right jugular vein as described previously (Kosten et al, 2000(Kosten et al, , 2004. An incision was made on the back and catheters passed under the skin and were threaded out of the incision.…”

Section: Experiments 1 Maintenance Of Cocaine Self-administration Behmentioning

confidence: 99%

“…Although a majority of cocaine addicts are male, female addicts are more likely than males to have comorbid post-traumatic stress disorder (Najavits et al, 1998) or a history of child abuse (Wechsberg et al, 1998). In rats, stress increases the ability of psychoactive drugs to enhance locomotor activity (Herman et al, 1984;Leyton and Stewart, 1990;Deroche et al, 1995;Haile et al, 2001), support place conditioning (Bell et al, 1997;Will et al, 1998;Haile et al, 2001), and promote acquisition of self-administration behavior (Piazza et al, 1990;Deminiere et al, 1992;Haney et al, 1995;Tidey and Miczek, 1997;Kosten et al, 2000). A few studies have examined the effects of stress on drug self-administration after behavior is well established (ie maintenance conditions), and report enhanced responding after stress (Shaham and Stewart, 1994;Zhang et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Heightened Cocaine and Food Self-Administration in Female Rats with Neonatal Isolation Experience

Kosten

Zhang

Kehoe

2005

Neuropsychopharmacol

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Previously, we demonstrated that the early life stress of neonatal isolation facilitates acquisition of cocaine and food self-administration in adult female rats. We now test whether it enhances responding for these reinforcers after operant performance is established. Adult female rats were derived from litters that were either subjected to neonatal isolation (1 h/day isolation; postnatal days 2-9) or were nonhandled and assigned to one of two experiments. In Experiment 1, female rats well trained to self-administer cocaine were tested under a fixed-ratio 3 (FR3) schedule with several cocaine doses (0.0625-1.0 mg/kg/infusion) and under a progressive-ratio (PR) schedule (0, 0.5, and 1.0 mg/kg/infusion cocaine). In Experiment 2, female rats well trained to respond for food reinforcers under an FR15 schedule were tested under two PR schedules. Results show that neonatal isolation enhanced responding for cocaine under both schedules of reinforcement and increased responding for food under a PR schedule of reinforcement. These data extend our previous acquisition study in female rats to show that neonatal isolation enhances responding under maintenance conditions. These enduring behavioral changes may relate to the ability of neonatal isolation to increase striatal dopamine responses to psychostimulants, effects we showed previously in infant and juvenile rats.

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