Enhanced 5-HT2A Receptor Status in the Hypothalamus and Corpus Striatum of Ethanol-Treated Rats

Abstract

The present study demonstrated the enhanced 5-HT(2A) receptor status in hypothalamus and corpus striatum. The ethanol-induced enhanced 5-HT(2A) receptors in the hypothalamus and corpus striatum has clinical significance in the better management of ethanol addiction. This will have therapeutic application.

Zolmitriptan and human aggression: interaction with alcohol

“…It has been demonstrated that low levels of serotonin are associated with increased aggressive behavior Miczek et al 2002) and that the administration of alcohol gives rise to aggressive behavior (Bushman 1997;Taylor 1976;Giancola et al 2003). Additionally, alcoholics have lower serotonin levels , raising serotonin levels can curb alcohol intake (Sellers et al 1992), and alcohol can decrease serotonin release and binding affinity (Akash et al 2008). Therefore, augmenting serotonin function concurrently with the administration of alcohol may diminish some of the aggression-heightening effects of alcohol.…”

“…Subsequently, as a means of decreasing appetite for alcohol, SSRIs have been used effectively to lower consumption rates in a group of alcoholics (Sellers et al 1992). In rodents, ethanol administration decreased 5-HT/5-HIAA turnover in the hypothalamus (Akash et al 2008), suggesting that the release of 5-HT may be down-regulated following ethanol administration. Further, serotonin's affinity for its receptors decreased in some brain regions following ethanol administration (Akash et al 2008), so ethanol may compromise serotonin function in multiple ways.…”

“…In rodents, ethanol administration decreased 5-HT/5-HIAA turnover in the hypothalamus (Akash et al 2008), suggesting that the release of 5-HT may be down-regulated following ethanol administration. Further, serotonin's affinity for its receptors decreased in some brain regions following ethanol administration (Akash et al 2008), so ethanol may compromise serotonin function in multiple ways. Alcohol may only decrease 5-HT in alcohol-exposed mice, rather than alcohol-naïve mice, and this may differentially affect aggressive behavior, complicating the relationship between 5-HT, alcohol and aggression (Faccidomo et al 2008).…”

Enhanced dopamine D2 receptor function in hypothalamus and corpus striatum: their role in liver, plasma and in vitro hepatocyte ALDH regulation in ethahol treated rats

“…Enhanced 5-HT 2A receptor status in the hypothalamus and corpus striatum of ethanol treated rats was reported [43]. Ethanol also acts directly through the production of neuroamines that interact with dopaminergic systems [13,44].…”

Research Letter: Structural Combination of Established 5‐HT2A Receptor Ligands: New Aspects of the Binding Mode

“…Moreover, most drugs that are currently used for the treatment of psychiatric disorders (e.g., Alzheimer’s disease, depression, mania, schizophrenia, autism, obsessive compulsive , alcoholism , disorder, and anxiety disorders) are thought to act, at least partially, through serotoninergic mechanisms (2). Most if not all clinically approved atypical antipsychotic drugs are potent 5‐HT 2A receptor antagonists (3,4).…”