Engraving the Surface of Electrospun Microfibers with Nanoscale Grooves Promotes the Outgrowth of Neurites and the Migration of Schwann Cells

Wu, Tong; Xue, Jiajia; Xia, Younan

doi:10.1002/ange.202002593

Cited by 4 publications

(9 citation statements)

References 47 publications

(81 reference statements)

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“…However, the incorporation of these features is shown to increase the roughness of electrospun fibers and, in turn, increase cell adhesion and proliferation [ 130 , 131 ]; thus, we can hypothesize that these features may promote increased adhesion and proliferation of Schwann cells as well. Nano-grooved electrospun fibers, formed through phase separation and the subsequent stretching of the fibers during the electrospinning process, are shown to have beneficial effects on Schwann cells in vitro [ 132 , 133 ]. Huang et al found that the presence of nanogrooves on electrospun cellulose acetate butyrate fibers improved Schwann cell elongation compared to smooth fibers [ 132 ].…”

Section: Peripheral Nervous System Glia and Electrospun Fibersmentioning

confidence: 99%

“…Huang et al found that the presence of nanogrooves on electrospun cellulose acetate butyrate fibers improved Schwann cell elongation compared to smooth fibers [ 132 ]. Further, Wu et al observed greater maximum and average Schwann cell migration on nano-grooved electrospun PCL fibers compared to smooth PCL fibers [ 133 ].…”

Section: Peripheral Nervous System Glia and Electrospun Fibersmentioning

confidence: 99%

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Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

et al. 2020

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Electrospinning is a fabrication technique used to produce nano- or micro- diameter fibers to generate biocompatible, biodegradable scaffolds for tissue engineering applications. Electrospun fiber scaffolds are advantageous for neural regeneration because they mimic the structure of the nervous system extracellular matrix and provide contact guidance for regenerating axons. Glia are non-neuronal regulatory cells that maintain homeostasis in the healthy nervous system and regulate regeneration in the injured nervous system. Electrospun fiber scaffolds offer a wide range of characteristics, such as fiber alignment, diameter, surface nanotopography, and surface chemistry that can be engineered to achieve a desired glial cell response to injury. Further, electrospun fibers can be loaded with drugs, nucleic acids, or proteins to provide the local, sustained release of such therapeutics to alter glial cell phenotype to better support regeneration. This review provides the first comprehensive overview of how electrospun fiber alignment, diameter, surface nanotopography, surface functionalization, and therapeutic delivery affect Schwann cells in the peripheral nervous system and astrocytes, oligodendrocytes, and microglia in the central nervous system both in vitro and in vivo. The information presented can be used to design and optimize electrospun fiber scaffolds to target glial cell response to mitigate nervous system injury and improve regeneration.

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Section: Peripheral Nervous System Glia and Electrospun Fibersmentioning

confidence: 99%

Section: Peripheral Nervous System Glia and Electrospun Fibersmentioning

confidence: 99%

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

et al. 2020

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“…Grooved structures are considered very effective in promoting axonal guidance, as they can provide more sensing targets and appropriate contact areas for the growth cones of neuritis [46]. Micropatterned pure-SF hydrogels (Topo@TPSF) were successfully fabricated by in situ micromolding with PDMS stamps.…”

Section: Mechanical Property and Surface Topologymentioning

confidence: 99%

Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

Chen

Tang

et al. 2021

Nanotechnology Reviews

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Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration. Herein, a pure silk fibroin (SF) hydrogel with a combination of high-strength and aligned microgrooved topographic structure is reported. The hydrogels exhibit excellent mechanical properties with high strength. Good biocompatibility also allows the hydrogels to support cell survival. Significantly, the hydrogel with aligned microgrooved structures enables the aligned growth of Schwann cells. Moreover, the hydrogel holds a strong capacity for promoting axon growth and guiding neurite sprouting. Thus, this micropatterned SF hydrogel would have great potential for peripheral nerve regeneration.

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“…In addition, the secondary morphology of fibers has an important effect on the properties of fibers. In the past few decades, the preparation of porous fibers [20], wrinkled fibers [21] and grooved fibers [22] by electrospinning has been reported. Fig.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that the composition and structure of electrospun fiber can improve and change their properties and applications. The common secondary structure of the electrospinning fiber is porous [23][24][25][26], hollow [27][28][29][30], groove [22,31,32], belt-like [33], etc. The coarse surface of grooved fibers is conducive to cell adhesion, and the orientation of groove fibers can induce axon growth well, so groove fibers can be used for tissue engineering [34].…”

Section: Introductionmentioning

confidence: 99%

Grooved Fibers: Preparation Principles Through Electrospinning and Potential Applications

Zhan

Deng

et al. 2021

Adv. Fiber Mater.

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The surface morphology of micro-and nano-scale fiber determines its application to a great extent. At present, a variety of secondary morphology of microfibers and nanofibers, such as porous, wrinkle, groove and so on, have been prepared. Among them, grooved micro-and nano-fibers are attracting more and more attention because of their unique morphology and properties. In this paper, we review the literature on grooved fibers due to void-based elongation, wrinkle-based elongation, collapsed jet-based elongation and selective dissolution. By contrast, the method of phase separation is simpler and more commonly used than selective dissolution. What is more interesting is that the number and depth of grooves on the fiber surface can be well controlled by adjusting the experimental parameters, which greatly increases the research value and application fields of grooves micro-nano fibers. Grooved fibers can be made from a range of materials: polycaprolactone (PCL), polylactic acid (PLA), polystyrene (PS), cellulose acetate butyrate (CAB) and other polymers. The applications of grooved micro-nano fibers are discussed in detail, including peripheral nerve regeneration, water manipulation and energy conversion.

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Engraving the Surface of Electrospun Microfibers with Nanoscale Grooves Promotes the Outgrowth of Neurites and the Migration of Schwann Cells

Cited by 4 publications

References 47 publications

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

Grooved Fibers: Preparation Principles Through Electrospinning and Potential Applications

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