Engraftment of human mesenchymal stem cells in a severely immunodeficient mouse
Yuko Kato,
Ryoji Ito,
Takeshi Taketani
et al.
Abstract:The transplantation of human mesenchymal stromal/stem cells (hMSCs) has potential as a curative and permanent therapy for congenital skeletal diseases. However, the self-renewal and differentiation capacities of hMSCs markedly vary. Therefore, cell proliferation and trilineage differentiation capacities were tested in vitro to characterize hMSCs before their clinical use. However, it remains unclear whether the ability of hMSCs in vitro accurately predicts that in living animals. The xenograft model is an alte… Show more
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