Engraftable Induced Pluripotent Stem Cell-Derived Neural Precursors for Brain Repair

Zygogianni, Ourania; Kouroupi, Georgia; Taoufik, Era; Matsas, Rebecca

doi:10.1007/978-1-0716-0655-1_3

Cited by 6 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cell therapies have emerged as potential treatments for neurological disorders and aging [ 271 - 296 ]. Stem cells can proliferate and differentiate into multiple cellular lineages.…”

Section: Resultsmentioning

confidence: 99%

Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

Kim¹,

Sachdev²,

Braidy³

2022

Aging and disease

View full text Add to dashboard Cite

Owing to the global exponential increase in population ageing, there is an urgent unmet need to develop reliable strategies to slow down and delay the ageing process. Age-related neurodegenerative diseases are among the main causes of morbidity and mortality in our contemporary society and represent a major socio-economic burden. There are several controversial factors that are thought to play a causal role in brain ageing which are continuously being examined in experimental models. Among them are oxidative stress and brain inflammation which are empirical to brain ageing. Although some candidate drugs have been developed which reduce the ageing phenotype, their clinical translation is limited. There are several strategies currently in development to improve brain ageing. These include strategies such as caloric restriction, ketogenic diet, promotion of cellular nicotinamide adenine dinucleotide (NAD + ) levels, removal of senescent cells, ‘young blood’ transfusions, enhancement of adult neurogenesis, stem cell therapy, vascular risk reduction, and non-pharmacological lifestyle strategies. Several studies have shown that these strategies can not only improve brain ageing by attenuating age-related neurodegenerative disease mechanisms, but also maintain cognitive function in a variety of pre-clinical experimental murine models. However, clinical evidence is limited and many of these strategies are awaiting findings from large-scale clinical trials which are nascent in the current literature. Further studies are needed to determine their long-term efficacy and lack of adverse effects in various tissues and organs to gain a greater understanding of their potential beneficial effects on brain ageing and health span in humans.

show abstract

“…Cell therapies have emerged as potential treatments for neurological disorders and aging [ 271 - 296 ]. Stem cells can proliferate and differentiate into multiple cellular lineages.…”

Section: Resultsmentioning

confidence: 99%

Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

Kim¹,

Sachdev²,

Braidy³

2022

Aging and disease

View full text Add to dashboard Cite

show abstract

“…iPSCs and ESCs may be tumorigenic due to their capacity for cellular growth in cell transplantation and other treatments. This problem was addressed by [68] by implementing optimised directed differentiation protocols to generate the desired precursor cell types and by using cellular enrichment techniques to eliminate unnecessary cells in order to choose only the cells with a restricted proliferation potential for transplantation.…”

Section: Acute Humoral Xenograft Rejection (Ahxr)mentioning

confidence: 99%

Xenotransplantation: past, present, and future directions

Eissa

Badrkhan

Shaban

et al. 2022

Highlights in BioScience

View full text Add to dashboard Cite

Xenotransplantation, in its broadest sense, is the transplantation, implantation, or infusion of cells, tissues, or organs from one species to another. While there is a high demand for human tissues, cells, and organs for use in clinical transplantation, they are often in short supply. Recent scientific and biotechnological advancements, coupled with the scarcity of human allografts, have led to renewed interest in developing exploratory treatment strategies that use xenotransplantation products in human recipients. However, despite its potential benefits, the use of xenotransplantation is still limited due to various considerations, as discussed in this review of the past, present, and future directions of xenotransplantation. One of the key ethical concerns surrounding xenotransplantation is the potential impact on the animals from which the cells, tissues, or organs are obtained. As with genetic modification to fix genetic defects or prevent disease, the ideal outcome for these animals is that they will be better off as a result of the change. However, unless there are major changes in the way science is taught to incorporate ethics into recognized scientific theory and practice, these concerns will not be adequately addressed

show abstract

“…iPSCs and ESCs have potential tumorigenic properties owing to their cellular overgrowth in cell transplantation and other therapies. To solve this problem, Zygogianni et al [ 46 ] implemented optimized directed differentiation protocols to yield the desired precursor cell types and utilized cellular enrichment procedures to remove unwanted cells to select only the cells with a restricted proliferation potential for transplantation[ 46 ].…”

Section: Problems and Solutions Of Xenogeneic Stem Cell Transplantationmentioning

confidence: 99%

Xenogeneic stem cell transplantation: Research progress and clinical prospects

Jiang¹,

Li²,

Liu³

2021

WJCC

View full text Add to dashboard Cite

Organ transplantation is the ultimate treatment for end-stage diseases such as heart and liver failure. However, the severe shortage of donor organs has limited the organ transplantation progress. Xenogeneic stem cell transplantation provides a new strategy to solve this problem. Researchers have shown that xenogeneic stem cell transplantation has significant therapeutic effects and broad application prospects in treating liver failure, myocardial infarction, advanced type 1 diabetes mellitus, myelosuppression, and other end-stage diseases by replacing the dysfunctional cells directly or improving the endogenous regenerative milieu. In this review, the sources, problems and solutions, and potential clinical applications of xenogeneic stem cell transplantation will be discussed.

show abstract

Engraftable Induced Pluripotent Stem Cell-Derived Neural Precursors for Brain Repair

Cited by 6 publications

References 43 publications

Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

Xenotransplantation: past, present, and future directions

Xenogeneic stem cell transplantation: Research progress and clinical prospects

Contact Info

Product

Resources

About