Engineering tissue morphogenesis: taking it up a Notch

Tiemeijer, Laura A.; Şanlıdağ, Sami; Bouten, Cvc Carlijn; Sahlgren, Cecilia

doi:10.1016/j.tibtech.2022.01.007

Cited by 11 publications

(13 citation statements)

References 93 publications

(187 reference statements)

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“…An increased control over tissue G&R via Notch manipulations may also aid in improving tissue engineered blood vessels and heart valves ( Carlson et al, 2007 ; Zohorsky and Mequanint, 2021 ; Tiemeijer et al, 2022 ; Karakaya and Van Asten et al 2022 ). Such manipulations may consist of immobilizing external Jagged ligands to scaffolds ( Beckstead et al, 2006 ; Putti et al, 2019a , 2019b ), a technique that has previously been found beneficial for tissue development ( Beckstead et al, 2006 ; Wen et al, 2014 ; Dishowitz et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

Asten

Ristori²,

Nolan³

et al. 2022

Journal of the Mechanical Behavior of Biomedical Materials

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Section: Discussionmentioning

confidence: 99%

Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

Asten

Ristori²,

Nolan³

et al. 2022

Journal of the Mechanical Behavior of Biomedical Materials

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“…The Notch pathway influences cell fate during development and morphogenesis [ 27 ]. Notch signaling dysregulation and somatic alterations in the genes encoding Notch signaling components drive various types of human cancer [ 14 , 28 , 29 ].…”

Section: The Notch Signaling Pathwaymentioning

confidence: 99%

Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance

Chimento

D’Amico

Pezzi

et al. 2022

IJMS

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Notch signaling dysregulation encourages breast cancer progression through different mechanisms such as stem cell maintenance, cell proliferation and migration/invasion. Furthermore, Notch is a crucial driver regulating juxtracrine and paracrine communications between tumor and stroma. The complex interplay between the abnormal Notch pathway orchestrating the activation of other signals and cellular heterogeneity contribute towards remodeling of the tumor microenvironment. These changes, together with tumor evolution and treatment pressure, drive breast cancer drug resistance. Preclinical studies have shown that targeting the Notch pathway can prevent or reverse resistance, reducing or eliminating breast cancer stem cells. In the present review, we will summarize the current scientific evidence that highlights the involvement of Notch activation within the breast tumor microenvironment, angiogenesis, extracellular matrix remodeling, and tumor/stroma/immune system interplay and its involvement in mechanisms of therapy resistance.

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“…Such engineered intercellular communication could facilitate the initiation of natural cellular processes that sculpt tissue into custom shapes required for tissue engineering or regenerative medicine applications 4 . At the same time, synthetic approaches offer an opportunity to elucidate principles governing the development of native tissues 5 as synthetic programs can mimic native ones for the spatial patterning of cellular differentiation and growth [6][7][8][9][10] . However, deploying synthetic signals in vivo to produce a desired response remains a major challenge, and little is known about the capacity of current technologies to achieve this goal.…”

Section: Introductionmentioning

confidence: 99%

“…Juxtacrine or contact-dependent signaling involves a signal-sending cell displaying a membrane-anchored ligand that engages a receptor on the surface of an adjacent signal receiving cell 1,2 . This leads to a signal response, such as a change in cell behavior important for morphogenesis, inflammation, tissue repair, or a host of other biological processes 2–5 . Synthetic cell-cell communication, where biological and engineering principles are combined to control tissue behavior, is emerging as a future biomedical tool that could allow natural developmental programs governing growth, differentiation, or cell death to be deployed at customized times or locations 6–8 .…”

Section: Introductionmentioning

confidence: 99%

Contact area and tissue growth dynamics shape synthetic juxtacrine signaling patterns

Dawson

Bryant

Jordan

et al. 2023

Preprint

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Cell-cell communication through direct contact is essential during multiple fundamental biological processes. Synthetic forms of contacted-mediated cell-cell communication can generate custom gene expression outputs, making them valuable for tissue engineering and regenerative medicine. Mechanisms underlying the spatiotemporal behavior of synthetic signal outputs in growing tissues, necessary to precisely control the output location and timing, are not well understood. Towards this goal, we combine theory and quantitative experiments to study patterns of synthetic Notch (synNotch) activation - a custom synthetic gene circuit that we implement within growingDrosophilawing imaginal discs. We show that cell growth, division, output synthesis and degradation are the key minimal parameters that predict the heterogeneous spatiotemporal patterns of synNotch activation in tissues. At long times, synNotch output forms a graded exponential spatial profile that extends several cell diameters from the signal source, indicating a role of cell division in signal propagation. Furthermore, we discover that the shape of the interface between ligand and receptor cells is important in determining the synNotch output. Overall, we elucidate key biophysical principles that underlie complex emergent spatiotemporal patterns of synNotch output in growing tissues.

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Engineering tissue morphogenesis: taking it up a Notch

Cited by 11 publications

References 93 publications

Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension

Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance

Contact area and tissue growth dynamics shape synthetic juxtacrine signaling patterns

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