Engineering thermoresponsive polyether-based nanogels for temperature dependent skin penetration

Asadian‐Birjand, Mazdak; Bergueiro, Julián; Rancan, Fiorenza; Cuggino, Julio César; Mutihac, Radu-Cristian; Achazi, Katharina; Dernedde, Jens; Blume-Peytayi, U.; Vogt, Annika; Calderón, Marcelo

doi:10.1039/c5py00924c

Cited by 52 publications

(34 citation statements)

References 47 publications

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“…The critical temperature is important, it should be high enough to not get triggered in room temperature and not too high such that high temperatures that can negatively affect the healthy tissue and the activity of the encapsulated drug are required for the material’s state to change. Thus, the suitable range for critical temperature is 35°C –45°C [229, 232].…”

Section: Active Drug Delivery Systemsmentioning

confidence: 99%

Drug delivery systems and materials for wound healing applications

Saghazadeh

Rinoldi

Schot

et al. 2018

Advanced Drug Delivery Reviews

550

421

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Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted.

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Section: Active Drug Delivery Systemsmentioning

confidence: 99%

Drug delivery systems and materials for wound healing applications

Saghazadeh

Rinoldi

Schot

et al. 2018

Advanced Drug Delivery Reviews

550

421

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“…Cationic lipid nanoparticles can also specifically enhance the DNA delivery. The mechanism of these nanoparticles relies on charge interactions between the nanoparticles and the skin, and enhanced delivery of an enhanced green fluorescent protein (EGFP) plasmid in vivo in BALB/c mice was shown to be on par with a lipid vesicle delivery system [ 210 ].…”

Section: Vaccination Into the Dermal Compartment Without Needle Anmentioning

confidence: 99%

Vaccination into the Dermal Compartment: Techniques, Challenges, and Prospects

Hettinga

Carlisle

2020

Vaccines

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In 2019, an ‘influenza pandemic’ and ‘vaccine hesitancy’ were listed as two of the top 10 challenges to global health by the WHO. The skin is a unique vaccination site, due to its immune-rich milieu, which is evolutionarily primed to respond to challenge, and its ability to induce both humoral and cellular immunity. Vaccination into this dermal compartment offers a way of addressing both of the challenges presented by the WHO, as well as opening up avenues for novel vaccine formulation and dose-sparing strategies to enter the clinic. This review will provide an overview of the diverse range of vaccination techniques available to target the dermal compartment, as well as their current state, challenges, and prospects, and touch upon the formulations that have been developed to maximally benefit from these new techniques. These include needle and syringe techniques, microneedles, DNA tattooing, jet and ballistic delivery, and skin permeabilization techniques, including thermal ablation, chemical enhancers, ablation, electroporation, iontophoresis, and sonophoresis.

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“…A range of drug delivery systems based on DEGMA have been reported, including micelles, hydrogels, NPs, and hybrid particles. 30,31 Poly(DEGMA) exhibits an LCST between 22 and 27°C, 32 but this can be tuned by copolymerization.…”

Section: Introductionmentioning

confidence: 99%

Glucose- and temperature-sensitive nanoparticles for insulin delivery

Wu¹,

Williams²,

Li³

et al. 2017

IJN

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Glucose- and temperature-sensitive polymers of a phenylboronic acid derivative and diethylene glycol dimethacrylate (poly(3-acrylamidophenyl boronic acid- b -diethylene glycol methyl ether methacrylate); p(AAPBA- b -DEGMA)) were prepared by reversible addition–fragmentation chain transfer polymerization. Successful polymerization was evidenced by 1 H nuclear magnetic resonance and infrared spectroscopy, and the polymers were further explored in terms of their glass transition temperatures and by gel permeation chromatography (GPC). The materials were found to be temperature sensitive, with lower critical solution temperatures in the region of 12°C–47°C depending on the monomer ratio used for reaction. The polymers could be self-assembled into nanoparticles (NPs), and the zeta potential and size of these particles were determined as a function of temperature and glucose concentration. Subsequently, the optimum NP formulation was loaded with insulin, and the drug release was studied. We found that insulin was easily encapsulated into the p(AAPBA- b -DEGMA) NPs, with a loading capacity of ~15% and encapsulation efficiency of ~70%. Insulin release could be regulated by changes in temperature and glucose concentration. Furthermore, the NPs were non-toxic both in vitro and in vivo. Finally, the efficacy of the formulations at managing blood glucose levels in a murine hyperglycemic diabetes model was studied. The insulin-loaded NPs could reduce blood glucose levels over an extended period of 48 h. Since they are both temperature and glucose sensitive and offer a sustained-release profile, these systems may comprise potent new formulations for insulin delivery.

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Engineering thermoresponsive polyether-based nanogels for temperature dependent skin penetration

Abstract: Improved skin penetration of thermoresponsive nanogels into human skin at temperatures above the phase-transition temperature.

Cited by 52 publications

References 47 publications

Drug delivery systems and materials for wound healing applications

Drug delivery systems and materials for wound healing applications

Vaccination into the Dermal Compartment: Techniques, Challenges, and Prospects

Glucose- and temperature-sensitive nanoparticles for insulin delivery

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