Engineering the synthesis of unsaturated fatty acids by introducing desaturase improved the stress tolerance of yeast
Dingkang Wang,
Liying Hao,
Xue Jiao
et al.
Abstract:BACKGROUNDYeast is often used to build cell factories to produce various chemicals or nutrient substances, which means the yeast has to encounter stressful environments. Previous research reported that unsaturated fatty acids were closely related to yeast stress resistance. Engineering unsaturated fatty acids may be a viable strategy for enhancing the stress resistance of cells.RESULTSIn this study, two desaturase genes, OLE1 and FAD2 from Z. rouxii, were overexpressed in S. cerevisiae to determine how unsatur… Show more
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