Engineering the Cell-Semiconductor Interface: A Materials Modification Approach using II-VI and III-V Semiconductor Materials

Bain, Lauren; Ivanisevic, Albena

doi:10.1002/smll.201401450

Cited by 22 publications

(9 citation statements)

References 102 publications

(191 reference statements)

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“…This is a well‐known phenomenon for porous silicon and has been observed for other porous SiNW . It is possible that the porous nature of these SiNW will in itself enhances cell adhesion …”

Section: Resultsmentioning

confidence: 53%

Maximizing Transfection Efficiency of Vertically Aligned Silicon Nanowire Arrays

Elnathan

Delalat

Brodoceanu

et al. 2015

Adv Funct Materials

111

119

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Vertically aligned silicon nanowire (VA‐SiNW) arrays are emerging as a powerful new tool for gene delivery by means of mechanical transfection. In order to utilize this tool efficiently, uncertainties around the required design parameters need to be removed. Here, a combination of nanosphere lithography and templated metal‐assisted wet chemical etching is used to fabricate VA‐SiNW arrays with a range of diameters, heights, and densities. This fabrication strategy allows identification of critical parameters of surface topography and consequently the design of SiNW arrays that deliver plasmid with high transfection efficiency into a diverse range of human cells whilst maintaining high cell viability. These results illuminate the cell‐materials interactions that mediate VA‐SiNW transfection and have the potential to transform gene therapy and underpin future treatment modalities.

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Section: Resultsmentioning

confidence: 53%

Maximizing Transfection Efficiency of Vertically Aligned Silicon Nanowire Arrays

Elnathan

Delalat

Brodoceanu

et al. 2015

Adv Funct Materials

111

119

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“…37,[186][187][188][189][190] However, the PL intensity and the QY of InP QDs have generally been lower than those of CdSe and other II-VI QDs, due to less effective passivation of dangling bonds and surface defects. [191][192][193][194] To overcome this challenge, the InP core QDs can be coated with a shell of a wider bandgap semiconductor like ZnS or ZnSe. Tessier et al 161 produced InP/ZnSe and InP/ZnS core/shell QDs with emission peaks tunable from 510 nm to 630 nm and narrow full widths at half-maximum (FWHM) ranging from 46 to 63 nm (Figure 10).…”

Section: Inp and Inp/zns Quantum Dotsmentioning

confidence: 99%

New Generation Cadmium-Free Quantum Dots for Biophotonics and Nanomedicine

et al. 2016

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This review summarizes recent progress in the design and applications of cadmium-free quantum dots (Cd-free QDs), with an emphasis on their role in biophotonics and nanomedicine. We first present the features of Cd-free QDs and describe the physics and emergent optical properties of various types of Cd-free QDs whose applications are discussed in subsequent sections. Selected specific QD systems are introduced, followed by the preparation of these Cd-free QDs in a form useful for biological applications, including recent advances in achieving high photoluminescence quantum yield (PL QY) and tunability of emission color. Next, we summarize biophotonic applications of Cd-free QDs in optical imaging, photoacoustic imaging, sensing, optical tracking, and photothermal therapy. Research advances in the use of Cd-free QDs for nanomedicine applications are discussed, including drug/gene delivery, protein/peptide delivery, image-guided surgery, diagnostics, and medical devices. The review then considers the pharmacokinetics and biodistribution of Cd-free QDs and summarizes current studies on the in vitro and in vivo toxicity of Cd-free QDs. Finally, we provide perspectives on the overall current status, challenges, and future directions in this field.

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“…Current photofunctional nanomaterials used for biomedical applications include quantum dots, upconversion nanoparticles and gold nanoparticles, and each has merits and limitations. For instance, quantum dots have bright and size-tunable emission but are toxic and experience blinking 7 , 8 , 9 , 10 , 11 . Upconversion nanoparticles (UCNPs) are excitable by near-infrared light and allow imaging in deep tissues, but the upconversion efficiencies need to be improved 12 , 13 , 14 , 15 , 16 .…”

Section: Introductionmentioning

confidence: 99%

Luminescent gold nanocluster-based sensing platform for accurate H2S detection in vitro and in vivo with improved anti-interference

Gao

Zhang

et al. 2017

Light Sci Appl

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Gold nanoclusters (Au NCs) are promising luminescent nanomaterials due to their outstanding optical properties. However, their relatively low quantum yields and environment-dependent photoluminescence properties have limited their biological applications. To address these problems, we developed a novel strategy to prepare chitosan oligosaccharide lactate (Chi)-functionalized Au NCs (Au NCs@Chi), which exhibited emission with enhanced quantum yield and elongated emission lifetime as compared to the Au NCs, as well as exhibited environment-independent photoluminescence properties. In addition, utilizing the free amino groups of Chi onto Au NCs@Chi, we designed a FRET-based sensing platform for the detection of hydrogen sulfide (H2S). The Au NCs and the specific H2S-sensitive merocyanine compound were respectively employed as an energy donor and acceptor in the platform. The addition of H2S induced changes in the emission profile and luminescence lifetime of the platform with high sensitivity and selectivity. Utilization of the platform was demonstrated to detect exogenous and endogenous H2S in vitro and in vivo through wavelength-ratiometric and time-resolved luminescence imaging (TLI). Compared to previously reported luminescent molecules, the platform was less affected by experimental conditions and showed minimized autofluorescence interference and improved accuracy of detection.

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Engineering the Cell-Semiconductor Interface: A Materials Modification Approach using II-VI and III-V Semiconductor Materials

Cited by 22 publications

References 102 publications

Maximizing Transfection Efficiency of Vertically Aligned Silicon Nanowire Arrays

Maximizing Transfection Efficiency of Vertically Aligned Silicon Nanowire Arrays

New Generation Cadmium-Free Quantum Dots for Biophotonics and Nanomedicine

Luminescent gold nanocluster-based sensing platform for accurate H2S detection in vitro and in vivo with improved anti-interference

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