Engineering the bioelectrochemical interface using functional nanomaterials and microchip technique toward sensitive and portable electrochemical biosensors

Jia, Xiaofang; Dong, Shaojun; Wang, Erkang

doi:10.1016/j.bios.2015.05.037

Cited by 92 publications

(41 citation statements)

References 87 publications

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“…Common metal nanomaterials applied in electrochemical biosensor contain noble metals, metal oxides, metal sulfides, metal nitrides and bimetal composites. Recently, review articles concerning the applications of metal nanomaterials and CNMs in electrochemical biosensors have been published [92][93][94][95][96], helping readers who are interested in the area to obtain the sufficient information.…”

Section: Metal Nanomaterials/il-based Biosensorsmentioning

confidence: 99%

Recent advances in ionic liquid-based electrochemical biosensors

Wang

Hao

2016

Science Bulletin

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Section: Metal Nanomaterials/il-based Biosensorsmentioning

confidence: 99%

Recent advances in ionic liquid-based electrochemical biosensors

Wang

Hao

2016

Science Bulletin

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“…Engineering the bioelectrochemical sensing interface is crucial for improving its sensitivity [34]. In the literature, several methods have been used for this purpose, such as concentration of solution [35], polarization [36], addition of polyvinyl alcohol (PVA) [37], and addition of nanomaterials [34].…”

Section: Introductionmentioning

confidence: 99%

“…In the literature, several methods have been used for this purpose, such as concentration of solution [35], polarization [36], addition of polyvinyl alcohol (PVA) [37], and addition of nanomaterials [34]. Thickness also influences the sensitivity [38]; indeed, this is the simplest variable to manipulate the sensitivity instead of adding components, such as before mentioned, which increases the complexity in preparing the sample, and homogeneity has also shown to influence the electrical properties [39].…”

Section: Introductionmentioning

confidence: 99%

Feasibility of a Gelatin Temperature Sensor Based on Electrical Capacitance

Silva

Sorli

Calado

et al. 2016

Sensors

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The innovative use of gelatin as a temperature sensor based on capacitance was studied at a temperature range normally used for meat cooking (20–80 °C). Interdigital electrodes coated by gelatin solution and two sensors of different thicknesses (38 and 125 µm) were studied between 300 MHz and 900 MHz. At 38 µm, the capacitance was adequately measured, but for 125 µm the slope capacitance versus temperature curve decreased before 900 MHz due to the electrothermal breakdown between 60 °C and 80 °C. Thus, for 125 µm, the capacitance was studied applying 600 MHz. Sensitivity at 38 µm at 868 MHz (0.045 pF/°C) was lower than 125 µm at 600 MHz (0.14 pF/°C), influencing the results in the simulation (temperature range versus time) of meat cooking; at 125 µm, the sensitivity was greater, mainly during chilling steps. The potential of gelatin as a temperature sensor was demonstrated, and a balance between thickness and frequency should be considered to increase the sensitivity.

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“…A microfluidics based chamber with multiple microchannels can help to carryout multiple nucleic acid assays in a shorter span of time with higher precision and portability (results may be obtained on a smartphone device). Demonstrative studies have shown great potential with immunoassays for hIV marker proteins 13 . Development of optical array microchip biosensors holds immense potential for label free, expeditious detection of multiple bio-hazardous agents ranging from bacterial spore to proteinaceous toxins.…”

Section: Microfluidics and Applicationmentioning

confidence: 99%

“…Electrochemical biosensors when engineered with nanomaterials have been proven to showcase higher performance in terms of selectivity, stability and sensitivity. Also, functional nanomaterials when coupled with bio recognition elements can scale up biosensing by many folds 13 . Electrochemical enzymatic and aptamer biosensors or aptasensors, based on the integrated microchip could revolutionise point-of-care diagnostics and environmental monitoring.…”

Section: Microfluidics and Applicationmentioning

confidence: 99%

Microfluidic Integrated Technology: A Potential Tool for Portable Radiation Biodosimetry

et al. 2017

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In the event of a mass radiological or nuclear incident, a large number of individuals would require rapid biodosimetric screening for proper medical care, mitigation and follow-up procedures. Mass radiological triage is critical after any such large-scale event because of the need for Dose assessment of suffered individuals at an early stage. With the increasing probability of such unprecedented incidents around the world, the need for modelling and development of new medical countermeasures for potential future chemical, biological, radiological and nuclear has been well established. Unfortunately, the capacity of most of these methods are still restricted to laboratory establishments due to resource limitations, need of high end expertise or general immobility of bulky instruments required for the same. So far there exists no rapid diagnostic technique that may reliably discriminate levels of ionising radiation exposure based on samples collected at a single time point. In classical clinical settings, complete blood count, particularly the lymphocyte count is based on temporal assessment. The diagnostic ‘gold standard’ in the field of radiation biodosimetry is the dicentric chromosome assay which happens to be highly labour-intensive and extensively time consuming, rendering it inefficient in case of mass casualty situations. Advanced technologies such as microfluidic platform, BioMEMS, μTAS carry the potential to make system highly portable, cost efficient and independent of high skilled expertise. In this review of the latest advances in portable biodosimetry we evaluate our progress and identify areas that still need to be addressed to achieve true field-deployment readiness.

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Engineering the bioelectrochemical interface using functional nanomaterials and microchip technique toward sensitive and portable electrochemical biosensors

Cited by 92 publications

References 87 publications

Recent advances in ionic liquid-based electrochemical biosensors

Recent advances in ionic liquid-based electrochemical biosensors

Feasibility of a Gelatin Temperature Sensor Based on Electrical Capacitance

Microfluidic Integrated Technology: A Potential Tool for Portable Radiation Biodosimetry

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