Engineering synthetic artificial pancreas using chitosan hydrogels integrated with glucose-responsive microspheres for insulin delivery

Yin, Ruixue; He, Jing; Bai, Meirong; Huang, Cong; Wang, Kemin; Yang, Shih-Mo; Zhang, Wenjun

doi:10.1016/j.msec.2018.11.032

Cited by 30 publications

(23 citation statements)

References 41 publications

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“…Hence, glucose is closely related to body function, and sustained glucose monitoring promotes the strict control of blood glucose in diabetic ( Ma et al, 2018 ). Especially, Glucose-responsive system plays an important role in self-regulated insulin delivery to treat diabetes ( Yin et al, 2019 ). Recently, Li et al (2017) developed a novel biocompatible glucose-responsive hydrogel loaded with glucose oxidase, catalase, and insulin to deliver insulin for diabetes treatment.…”

Section: Smart Hydrogel In Biomedical Applicationmentioning

confidence: 99%

Rational Design of Smart Hydrogels for Biomedical Applications

Zhang

Huang

2021

Front. Chem.

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Hydrogels are polymeric three-dimensional network structures with high water content. Due to their superior biocompatibility and low toxicity, hydrogels play a significant role in the biomedical fields. Hydrogels are categorized by the composition from natural polymers to synthetic polymers. To meet the complicated situation in the biomedical applications, suitable host–guest supramolecular interactions are rationally selected. This review will have an introduction of hydrogel classification based on the formulation molecules, and then a discussion over the rational design of the intelligent hydrogel to the environmental stimuli such as temperature, irradiation, pH, and targeted biomolecules. Further, the applications of rationally designed smart hydrogels in the biomedical field will be presented, such as tissue repair, drug delivery, and cancer therapy. Finally, the perspectives and the challenges of smart hydrogels will be outlined.

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Section: Smart Hydrogel In Biomedical Applicationmentioning

confidence: 99%

Rational Design of Smart Hydrogels for Biomedical Applications

Zhang

Huang

2021

Front. Chem.

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“…The traditional pancreas is an external electronic device containing a continuous glucose monitor (CGM), while the synthetic or chemical pancreas is based on physiological physical and chemical stimuli and is administered as a drug formulation directly to the patient [49,102]. The synthetic pancreas is favored over the traditional artificial pancreas due to its improved therapeutic efficacy, small size, and minimally invasive implantable ability [49]. Over the last decade, a variety of natural biopolysaccharides have been exploited in the design and synthesis of many responsive DDSes.…”

Section: Controlled Release and Stimuli-responsive Systems For Nanmentioning

confidence: 99%

“…These systems allow for personalized healthcare and vastly improved control of BGLs [12]. There are three groups that have been developed for chemically controlled closed-loop systems, such as glucose oxidase, PBA, and Concanavalin A [49]. These systems will be discussed in detail below.…”

Section: Controlled Release and Stimuli-responsive Systems For Nanmentioning

confidence: 99%

“…Additionally, studies carried out by Yin et al demonstrated that ConA micro/nanospheres could be embedded in a polymer matrix, as illustrated in Figure 2, for ideal insulin therapy. However, more work needs to be carried out, as this was undertaken in vitro only [49].…”

Section: Controlled Release and Stimuli-responsive Systems For Nanmentioning

confidence: 99%

“…( a ) Schematic process of fabricating ConA microspheres via w / o emulsion-based crosslinking, ( b ) preparation of the chitosan-based scaffolds for insulin delivery, and ( c ) chemical structures of dextran glycidyl methacrylate (Dex-GMA), concanavalin-A (ConA), chitosan, and sodium tripolyphosphate (STPP) (reproduced with permission from Reference [49]).…”

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Polymer-Based Nanoparticle Strategies for Insulin Delivery

et al. 2019

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Diabetes mellitus (DM) is a chronic metabolic illness estimated to have affected 451 million individuals to date, with this number expected to significantly rise in the coming years. There are two main classes of this disease, namely type 1 diabetes (T1D) and type 2 diabetes (T2D). Insulin therapy is pivotal in the management of diabetes, with diabetic individuals taking multiple daily insulin injections. However, the mode of administration has numerous drawbacks, resulting in poor patient compliance. In order to optimize insulin therapy, novel drug delivery systems (DDSes) have been suggested, and alternative routes of administration have been investigated. A novel aspect in the field of drug delivery was brought about by the coalescence of polymeric science and nanotechnology. In addition to polymeric nanoparticles (PNPs), insulin DDSes can incorporate the use of nanoplatforms/carriers. A combination of these systems can bring about novel formulations and lead to significant improvements in the drug delivery system (DDS) with regard to therapeutic efficacy, bioavailability, increased half-life, improved transport through physical and chemical barriers, and controlled drug delivery. This review will discuss how recent developments in polymer chemistry and nanotechnology have been employed in a multitude of platforms as well as in administration routes for the safe and efficient delivery of insulin for the treatment of DM.

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Wearable Glucose Monitoring and Implantable Drug Delivery Systems for Diabetes Management

Zhang

Lim

et al. 2021

Adv Healthcare Materials

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The global cost of diabetes care exceeds $1 trillion each year with more than $327 billion being spent in the United States alone. Despite some of the advances in diabetes care including continuous glucose monitoring systems and insulin pumps, the technology associated with managing diabetes has largely remained unchanged over the past several decades. With the rise of wearable electronics and novel functional materials, the field is well‐poised for the next generation of closed‐loop diabetes care. Wearable glucose sensors implanted within diverse platforms including skin or on‐tooth tattoos, skin‐mounted patches, eyeglasses, contact lenses, fabrics, mouthguards, and pacifiers have enabled noninvasive, unobtrusive, and real‐time analysis of glucose excursions in ambulatory care settings. These wearable glucose sensors can be integrated with implantable drug delivery systems, including an insulin pump, glucose responsive insulin release implant, and islets transplantation, to form self‐regulating closed‐loop systems. This review article encompasses the emerging trends and latest innovations of wearable glucose monitoring and implantable insulin delivery technologies for diabetes management with a focus on their advanced materials and construction. Perspectives on the current unmet challenges of these strategies are also discussed to motivate future technological development toward improved patient care in diabetes management.

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Engineering synthetic artificial pancreas using chitosan hydrogels integrated with glucose-responsive microspheres for insulin delivery

Cited by 30 publications

References 41 publications

Rational Design of Smart Hydrogels for Biomedical Applications

Rational Design of Smart Hydrogels for Biomedical Applications

Polymer-Based Nanoparticle Strategies for Insulin Delivery

Wearable Glucose Monitoring and Implantable Drug Delivery Systems for Diabetes Management

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