Engineering Smart Nanofluidic Systems for Artificial Ion Channels and Ion Pumps: From Single‐Pore to Multichannel Membranes

Zhang, Zhen; Huang, Xiaodong; Qian, Yongchao; Chen, Wei-Peng; Wen, Liping; Jiang, Lei

doi:10.1002/adma.201904351

Cited by 102 publications

(92 citation statements)

References 165 publications

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“…The selectivity depends on the specific binding sites asymmetrically distributed along the inner channel walls. [ 70 ] Inspired by the selectivity of the biological ion channel protein, artificial smart channels that can selectively transport specific types of ions/molecules have been developed. [ 71,72 ]…”

Section: Propertiesmentioning

confidence: 99%

Construction of Metal‐Organic Frameworks (MOFs)–Based Membranes and Their Ion Transport Applications

Yang

Wang

et al. 2021

Small Science

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Biological ion channels with delicate ion transport functions exist widely in living organisms. Bioinspired solid‐state channels have emerged as promising platforms to mimic the working mechanism of natural channels. These channels help in understanding the mechanism of ion transport in biosystems and pave the way for applications in several interesting areas. Metal‐organic frameworks (MOFs), constructed by connecting metal ions and organic ligands, exhibit high porosity and unique pore structures. They also possess tunable pore sizes and are versatile in their compositions. And there are rich molecule/ion‐specific functional groups in the frameworks, which can intelligently modulate ion transport. Thus, MOFs are promising candidates that mimic biological ion channels. Herein, the recent progress in the design and construction of artificial solid‐state MOF‐based channels is focused on. The excellent ion transport properties of MOF‐based membranes are also summarized, including ionic selectivity, ionic rectification, and ionic gating. Following this, four emerging ion transport applications, namely, energy conversion, ion/molecule separation, biosensing, and water desalination, are highlighted. Finally, an outlook on future developments and challenges in this exciting research area is presented.

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Section: Propertiesmentioning

confidence: 99%

Construction of Metal‐Organic Frameworks (MOFs)–Based Membranes and Their Ion Transport Applications

Yang

Wang

et al. 2021

Small Science

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“…The successful construction of this switchable transport system is a vital step to the practical functions of AMMs in biological systems and may therefore provide a new strategy of building artificial transmembrane transport systems. Jiang and coworkers developed a series of light‐responsive nanoscale delivery systems based on azobenzene switches, as exemplified by a selective ATP transmembrane transport system prepared by immobilizing azo‐DNA onto the surface of conical polyimide (PI) nanochannels . In this system, the PI nanochannels act as templates, while the azobenzene switch renders the system light‐responsive.…”

Section: Microscale Applicationsmentioning

confidence: 99%

Driving Smart Molecular Systems by Artificial Molecular Machines

Shi

Zhang

Tian

et al. 2020

Advanced Intelligent Systems

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Biomolecular machines are widely present in nature, especially in complex living organisms, and are involved in important biological processes. Inspired by nature and increasingly mature synthetic technologies, a series of artificial molecular machines (AMMs) that exhibit similar processes and functions as biomolecular counterparts have been developed, and to date, some dramatic achievements have been obtained. Herein, the use of AMMs in smart systems and materials with controllable regulations and interesting functions are summarized, presenting the specific micro‐ to macroscale applications in solid surface modification, transmembrane transport, smart catalysts, liquid crystals, artificial molecular muscles, and stimuli‐responsive polymers. The challenges of developing novel complex AMMs with intelligent functions are discussed, and some potential solutions are proposed.

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“…These fungal effects on human health are spiraling, and the global mortality rates of fungal diseases now exceed that of malaria or breast cancer [ 4 , 5 ]. To eliminate fungal infections, many kinds of strategies have been developed, such as topical cream, oral antifungal drugs, suppository, and even surgery [ 6 – 10 ]. Among them, antifungal drugs such as azoles are the most typical and widespread frontline strategy used in humans [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Living Bacterial Microneedles for Fungal Infection Treatment

et al. 2020

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Fungal infections are everlasting health challenges all over the world, bringing about great financial and medical burdens. Here, inspired by the natural competition law of beneficial bacteria against other microbes, we present novel living microneedles (LMNs) with functionalized bacteria encapsulation for efficient fungal infection treatment. The chosen beneficial bacterial components, Bacillus subtilis (B. subtilis), which are naturally found on the human skin and widely used for food processing, can get nutrients from the skin and escape from the immune system with the help of microneedles. Besides, the encapsulated B. subtilis can continuously produce and secrete various potential antifungal agents which can directly bind to fungal cell surface-associated proteins and destruct the cell membranes, thus avoiding drug resistance. After immobilization in the LMNs, the bacteria can stay within the LMNs without invasion and the encapsulated bacteria together with microneedles can be removed after application. Thus, the side effects, especially the risk for subsequent bacterial infections, are controlled to a minimum to ensure security. In addition, strong penetrability of the microneedles enhances penetration of antifungal agents, and their heights can be adjusted according to the infected depth to acquire better therapeutic effects. These features make the LMNs potentially valuable for clinical applications.

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Engineering Smart Nanofluidic Systems for Artificial Ion Channels and Ion Pumps: From Single‐Pore to Multichannel Membranes

Cited by 102 publications

References 165 publications

Construction of Metal‐Organic Frameworks (MOFs)–Based Membranes and Their Ion Transport Applications

Construction of Metal‐Organic Frameworks (MOFs)–Based Membranes and Their Ion Transport Applications

Driving Smart Molecular Systems by Artificial Molecular Machines

Living Bacterial Microneedles for Fungal Infection Treatment

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