Engineering SIRPα cellular membrane-based nanovesicles for combination immunotherapy

Wang, Mingyue; Wang, Yanfang; Mu, Yeteng; Yang, Fuxu; Yang, Zhen; Liu, Yuxuan; Huang, Lili; Shi, Liyi; Guan, Xingang; Xie, Zhigang; Gu, Zhen

doi:10.1007/s12274-023-5397-4

Cited by 9 publications

(5 citation statements)

References 48 publications

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“…Cell membrane-derived nanovesicles are essentially distinct by their size (100–1000 nm in diameter) and production method. 37,38 They are phospholipid nanocarriers produced from cells that serve as signalosomes and deliver quantities of bioactive chemicals to particular target cells for signal transduction. 39 Nanovesicles derived from cell membrane are now widely acknowledged as key nanovehicles that regulate the biological activity of multicellular animals in an intercellular-transmission way.…”

Section: Introductionmentioning

confidence: 99%

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Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Raza,

Zafar,

Jiang

et al. 2024

Biomater. Sci.

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Section: Introductionmentioning

confidence: 99%

“…[34][35][36] Cell membrane-derived nanovesicles are essentially distinct by their size (100-1000 nm in diameter) and production method. 37,38 They are phospholipid nanocarriers produced…”

mentioning

confidence: 99%

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Raza,

Zafar,

Jiang

et al. 2024

Biomater. Sci.

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“…Therefore, S. aureus pathogenicity and its underlying virulence mechanisms have been a primary research focus. Staphylococcus aureus causes high mortality, which is associated with early excessive inflammation of unknown mechanisms ( Wang et al, 2023 ). Staphylococcus aureus has a powerful virulence secretion system to evade the host’s immune response, and may even promote excessive inflammatory response ( Mu et al, 2023 ); therefore, the host’s regulation of the immune response, especially the key mechanisms controlling inflammation, is crucial for successful resistance to Staphylococcus aureus .…”

Section: Introductionmentioning

confidence: 99%

GEO dataset mining analysis reveals novel Staphylococcus aureus virulence gene regulatory networks and diagnostic targets in mice

Xu,

Yang,

Lin

et al. 2024

Front. Mol. Biosci.

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Staphylococcus (S.) aureus infection is a serious, worldwide health concern, particularly in many communities and hospitals. Understanding the S. aureus pathogenetic regulatory network will provide significant insights into diagnostic target screening to improve clinical treatment of diseases caused by S. aureus. We screened differentially expressed genes between normal mice and S. aureus-infected mice. We used the Gene Expression Omnibus (GEO) DataSets database for functional analysis (GO-analysis) and the DAVID and KEGG databases for signaling pathway analyses. We next integrated the gene and pathway analyses with Transcriptional Regulatory Element Database (TRED) to build an antimicrobial resistance gene regulatory network of S. aureus. We performed association analysis of network genes and diseases using DAVID online annotation tools. We identified a total of 437 virulence genes and 15 transcription factors (TFs), as well as 444 corresponding target genes, in the S. aureus TF regulatory network. We screened seven key network nodes (Met, Mmp13, Il12b, Il4, Tnf, Ptgs2, and Ctsl), four key transcription factors (Jun, C3, Spil, and Il6) and an important signaling pathway (TNF). We hypothesized that the cytokine activity and growth factor activity of S. aureus are combinatorically cross-regulated by Met, Mmp13, Il12b, Il4, Tnf, Ptgs2, and Ctsl genes, the TFs Jun, C3, Spi1, and Il6, as well as the immune response, cellular response to lipopolysaccharide, and inflammatory response. Our study provides information and reference values for the molecular understanding of the S. aureus pathogenetic gene regulatory network.

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“…7 Therefore, there is an urgent need to develop safe and efficient delivery platforms for ICIs to achieve effective tumor eradication. [8][9][10] Given the vital role of chemotherapeutics in cancer therapy, chemotherapy-combined immune checkpoint blockade has proven to be an effective strategy for improving antitumor efficacy in many preclinical reports. 11 Chemotherapeutics can exert a potent cytotoxic effect against malignant cells and enhance the tumor immunogenicity, 12 triggering innate and adaptive immune responses for tumor killing.…”

Section: Introductionmentioning

confidence: 99%

“…7 Therefore, there is an urgent need to develop safe and efficient delivery platforms for ICIs to achieve effective tumor eradication. 8–10…”

Section: Introductionmentioning

confidence: 99%

Engineered elastin-like polypeptide-based hydrogel delivering chemotherapeutics and PD-L1 antibodies for potentiated cancer immunotherapy

Chen,

Cui,

et al. 2023

J. Mater. Chem. B

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Engineering SIRPα cellular membrane-based nanovesicles for combination immunotherapy

Cited by 9 publications

References 48 publications

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

GEO dataset mining analysis reveals novel Staphylococcus aureus virulence gene regulatory networks and diagnostic targets in mice

Engineered elastin-like polypeptide-based hydrogel delivering chemotherapeutics and PD-L1 antibodies for potentiated cancer immunotherapy

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