Engineering Sensory Ganglion Multicellular System to Model Tissue Nerve Ingrowth
Junxuan Ma,
Janick Eglauf,
Sibylle Grad
et al.
Abstract:Discogenic pain is associated with deep nerve ingrowth in annulus fibrosus tissue (AF) of intervertebral disc (IVD). To model AF nerve ingrowth, primary bovine dorsal root ganglion (DRG) micro‐scale tissue units are spatially organised around an AF explant by mild hydrodynamic forces within a collagen matrix. This results in a densely packed multicellular system mimicking the native DRG tissue morphology and a controlled AF‐neuron distance. Such a multicellular organisation is essential to evolve populational‐… Show more
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