Engineering protein translocation and unfolded protein response enhanced human PH-20 secretion in Pichia pastoris
Yue-Sheng Zhang,
Jin-Song Gong,
Jia-Yu Jiang
et al.
Abstract:Hyaluronidases catalyze the degradation of hyaluronan (HA), which is finding rising applications in medicine, cosmetic, and food industries. Recombinant expression of hyaluronidases in microbial hosts has been given special attention as a sustainable way to substitute animal tissue-derived hyaluronidases. In this study, we focused on optimizing the secretion of hyaluronidase from Homo sapiens in Pichia pastoris by secretion pathway engineering. The recombinant hyaluronidase was first expressed under the contro… Show more
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