Engineering primitive multiscale chimeric vasculature by combining human microvessels with explanted murine vessels
Emily A. Margolis,
Lucia S. Choi,
Nicole E. Friend
et al.
Abstract:Strategies to separately manufacture arterial-scale tissue engineered vascular grafts and microvascular networks have been well-established, but efforts to bridge these two length scales to create hierarchical vasculature capable of supporting parenchymal cell functions or restoring perfusion to ischemic tissues have been limited. This work aimed to create multiscale vascular constructs by assessing the capability of macroscopic vessels isolated from mice to form functional connections to engineered capillary … Show more
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