Engineering pectin-based hollow nanocapsules for delivery of anticancer drug

Feng, Ji; Li, Junjie; Qin, Zhihui; Yang, Boguang; Zhang, Ershuai; Dong, Dianyu; Wang, Jinmei; Yan, Wen; Tian, Liang; Yao, Fanglian

doi:10.1016/j.carbpol.2017.08.107

Cited by 65 publications

(26 citation statements)

References 38 publications

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“…Pectin is a branched polysaccharide present in the cell wall of land plants and can be extracted from peel and pulp of fruits (e.g., orange, lemon, apple) [187]. Pectin has been explored for drug delivery [188,189], wound healing [190][191][192], cell encapsulation [193] and cancer therapy [188,194,195]. Pectin contains at least three covalently linked polysaccharide domains, the linear homogalacturonan (HGA) domain and the branched (or 'hairy') domains rhamnogalacturonan-I (RG-I) and rhamnogalacturonan-II (RG-II) [196].…”

Section: Pectinmentioning

confidence: 99%

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

et al. 2020

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Glycosaminoglycans (GAG) are long, linear polysaccharides that display a wide range of relevant biological roles. Particularly, in the extracellular matrix (ECM) GAG specifically interact with other biological molecules, such as growth factors, protecting them from proteolysis or inhibiting factors. Additionally, ECM GAG are partially responsible for the mechanical stability of tissues due to their capacity to retain high amounts of water, enabling hydration of the ECM and rendering it resistant to compressive forces. In this review, the use of GAG for developing hydrogel networks with improved biological activity and/or mechanical properties is discussed. Greater focus is given to strategies involving the production of hydrogels that are composed of GAG alone or in combination with other materials. Additionally, approaches used to introduce GAG-inspired features in biomaterials of different sources will also be presented.

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Section: Pectinmentioning

confidence: 99%

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

et al. 2020

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“…It has several unique properties that have enabled it to be used in food industry, people use pectin to control high cholesterol and diabetes, and it is used for the delivery of variety of drugs, proteins and cells. It is also used to prevent poisoning from heavy metal, colon cancer and prostate cancer (Glinsky and Raz, 2009;Guess et al, 2003;Ji et al, 2017;Wong et al, 2011;Zhang et al, 2015). Inspired by its numerous uses in diverse fields, we have decided to calculate its topological descriptors.…”

Section: Motivationmentioning

confidence: 99%

Computing topological descriptors for the molecular structure of anticancer drug

al.¹

2019

Int. j. adv. appl. sci.

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The aim of this paper is to investigate various degree based, neighborhood based and eccentricity based topological indices by considering edge partitioning method, for the molecular structure of anticancer drug Pectin, without going to the wet lab. We have computed general Randic index, general sum connectivity index, general harmonic index, Zareb indices, atom bond connectivity, geometric arithmetic index, the 4 th version of atom bond connectivity index, the 5 th version of geometric arithmetic index, Sanskruti index, the 5 th version of atom bond connectivity index and 4 th version of the geometric arithmetic index, for the molecular graph.

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“…In addition, HNCaps have excellent stability, relatively long circulation in blood and better mechanical properties than other DDSs (e.g. liposomes and solid lipid NPs) . Some synthetic strategies, including layer‐by‐layer self‐assembly, sol–gel process, template synthesis, crosslinking of micelles, directed self‐assembly approaches and heterophase polymerization, have been applied for the fabrication of HNCaps .…”

Section: Introductionmentioning

confidence: 99%

PEGylated hollow pH‐responsive polymeric nanocapsules for controlled drug delivery

Massoumi

Abbasian

Jahanban‐Esfahlan

et al. 2020

Polymer International

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Novel pH-responsive PEGylated hollow nanocapsules (HNCaps) were fabricated through a combination of distillationprecipitation copolymerization and surface thiol-ene 'click' grafting reaction. For this purpose, SiO 2 nanoparticles were synthesized using the Stöber approach, and then modified using 3-(trimethoxysilyl)propyl methacrylate (MPS). Afterward, a mixture of triethyleneglycol dimethacrylate (as crosslinker), acrylic acid (AA; as pH-responsive monomer) and MPS-modified SiO 2 nanoparticles (as sacrificial template) was copolymerized using the distillation-precipitation approach to afford SiO 2 @PAA coreshell nanoparticles. The SiO 2 core was etched from SiO 2 @PAA using HF solution, and the obtained PAA HNCaps were grafted with a thiol-end-capped poly(ethylene glycol) (PEG) through a thiol-ene 'click' reaction to produce PAA-g-PEG HNCaps. The fabricated HNCaps were loaded with doxorubicin hydrochloride (DOX) as a model anticancer drug, and their drug loading and encapsulation efficiencies as well as pH-dependent drug release behavior were investigated. The anticancer activity of the drug-loaded HNCaps was extensively evaluated using MTT assay against human breast cancer cells (MCF7). The cytotoxicity assay results as well as superior physicochemical and biological features of the fabricated HNCaps mean that the developed DOX-loaded HNCaps have excellent potential for cancer chemotherapy.

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Engineering pectin-based hollow nanocapsules for delivery of anticancer drug

Cited by 65 publications

References 38 publications

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

Computing topological descriptors for the molecular structure of anticancer drug

PEGylated hollow pH‐responsive polymeric nanocapsules for controlled drug delivery

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