Engineering optical tools for remotely controlled brain stimulation and regeneration

Rodrigues, Artur Filipe; Rebelo, Catarina; Reis, Tiago; Simões, Susana; Bernardino, Liliana; Peça, João; Ferreira, Lino

doi:10.1039/d2bm02059a

Cited by 3 publications

(1 citation statement)

References 192 publications

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“…Representative upconversion nanoparticles (UCNPs) can convert external NIR light into visible light to activate opsins for neuromodulation. In addition to NIR light, other physical fields (such as magnetic field, focused ultrasound (FUS), and x-rays) can also be transduced into visible light to activate opsins to excite and silence neurons, demonstrating their effectiveness and superiority in deep-tissue-penetrating wireless optogenetics (Rodrigues et al 2023). Apart from visible light-emitting nanoparticles, macromolecular infrared nanotransducers have a high photothermal conversion efficiency in the NIR-II window, which can generate local heat to remotely activate thermosensitive transient receptor potential vanilloid 1 (TRPV1) channels for wireless neuromodulation.…”

Section: Introductionmentioning

confidence: 99%

Functional nanotransducer-mediated wireless neural modulation techniques

Li,

Lan

et al. 2024

Phys. Med. Biol.

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Functional nanomaterials have emerged as versatile nanotransducers for wireless neural modulation because of their minimal invasion and high spatiotemporal resolution. The nanotransducers can convert external excitation sources (e.g., NIR light, X-rays, and magnetic fields) to visible light (or local heat) to activate optogenetic opsins and thermosensitive ion channels for neuromodulation. The present review provides insights into the fundamentals of the mostly used functional nanomaterials in wireless neuromodulation including upconversion nanoparticles, nanoscintillators, and magnetic nanoparticles. We further discussed the recent developments in design strategies of functional nanomaterials with enhanced energy conversion performance that have greatly expanded the field of neuromodulation. We summarized the applications of functional nanomaterials-mediated wireless neuromodulation techniques, including exciting/silencing neurons, modulating brain activity, controlling motor behaviors, and regulating peripheral organ function in mice. Finally, we discussed some key considerations in functional nanotransducer-mediated wireless neuromodulation along with the current challenges and future directions.

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Section: Introductionmentioning

confidence: 99%

Functional nanotransducer-mediated wireless neural modulation techniques

Li,

Lan

et al. 2024

Phys. Med. Biol.

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Biomedical applications of stimuli‐responsive nanomaterials

Chen,

Wu,

Chen

2024

MedComm

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Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties. Currently, stimuli‐responsive nanomaterials that can respond to endogenous or exogenous stimulus display strong potentials in biomedical applications. In comparison with conventional nanomaterials, stimuli‐responsive nanomaterials can improve therapeutic efficiency and reduce the toxicity of drugs toward normal tissues through specific targeting and on‐demand drug release at pathological sites. In this review, we summarize the responsive mechanism of a variety of stimulus, including pH, redox, and enzymes within pathological microenvironment, as well as exogenous stimulus such as thermal effect, magnetic field, light, and ultrasound. After that, biomedical applications (e.g., drug delivery, imaging, and theranostics) of stimuli‐responsive nanomaterials in a diverse array of common diseases, including cardiovascular diseases, cancer, neurological disorders, inflammation, and bacterial infection, are presented and discussed. Finally, the remaining challenges and outlooks of future research directions for the biomedical applications of stimuli‐responsive nanomaterials are also discussed. We hope that this review can provide valuable guidance for developing stimuli‐responsive nanomaterials and accelerate their biomedical applications in diseases diagnosis and treatment.

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Biomaterials-enabled electrical stimulation for tissue healing and regeneration

Kim,

Baby,

Lee

et al. 2024

Med-X

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The electrical microenvironment is considered a pivotal determinant in various pathophysiological processes, including tissue homeostasis and wound healing. Consequently, extensive research endeavors have been directed toward applying electricity to cells and tissues through external force devices or biomaterial-based platforms. In addition to in situ electroconductive matrices, a new class of electroactive biomaterials responsive to stimuli has emerged as a focal point of interest. These electroactive materials, in response to intrinsic biochemical (e.g., glucose) or external physical stimuli (e.g., light, magnetism, stress), hold significant potential for cell stimulation and tissue regeneration. In this communication, we underscore this distinct category of electroactive biomaterials, discussing the currently developed biomaterial platforms and their biological roles in stimulating cells and tissues during the healing and regeneration process. We also critically evaluate the inherent limitations and challenges of these biomaterials while offering forward-looking insights into their promise for future clinical translations. Graphical Abstract

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Engineering optical tools for remotely controlled brain stimulation and regeneration

Abstract: Neurological disorders are one of the world’s leading medical and societal challenges due to the lack of efficacy of the first line of treatments. Although pharmacological and non-pharmacological interventions have...

Cited by 3 publications

References 192 publications

Functional nanotransducer-mediated wireless neural modulation techniques

Functional nanotransducer-mediated wireless neural modulation techniques

Biomedical applications of stimuli‐responsive nanomaterials

Biomaterials-enabled electrical stimulation for tissue healing and regeneration

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