Engineering of combination drug delivery of pH/reduction response potential nanocarrier for the treatment of liver cancer

Jia, Yan; Xie, Shujie; Xia, Qin; Li, Xiang; Chen, Shuhuai; Shen, Jia

doi:10.1007/s13204-021-02312-6

Cited by 11 publications

(2 citation statements)

References 58 publications

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“…The amphiphilic polymer mPEG-PLA efficiently encapsulates DOX and CAP to create the dual-drug loaded nanomaterials CAP/DOX@NPs, which release the medicines in response to acid and reduction stimuli. 120 According to the confocal laser scanning microscopy findings and flow cytometry, the co-loaded drug NPs were quickly absorbed by the HepG2 liver cancer cell and released intracellularly. This led to enhanced cell deaths and synergistic therapeutic effects from the co-loaded drug NP.…”

Section: Application In Cancer Treatmentmentioning

confidence: 99%

RETRACTED: An Overview of Polymeric Nanoparticles-Based Drug Delivery System in Cancer Treatment

Dristant

Mukherjee

Saha

et al. 2023

Technol Cancer Res Treat

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Cancer is recognized as one of the world's deadliest diseases, with more than 10 million new cases each year. Over the past 2 decades, several studies have been performed on cancer to pursue solutions for effective treatment. One of the vital benefits of utilizing nanoparticles (NPs) in cancer treatment is their high adaptability for modification and amalgamation of different physicochemical properties to boost their anti-cancer activity. Various nanomaterials have been designed as nanocarriers attributing nontoxic and biocompatible drug delivery systems with improved bioactivity. The present review article briefly explained various types of nanocarriers, such as organic–inorganic-hybrid NPs, and their targeting mechanisms. Here a special focus is given to the synthesis, benefits, and applications of polymeric NPs (PNPs) involved in various anti-cancer therapeutics. It has also been discussed about the drug delivery approach by the functionalized/encapsulated PNPs (without/with targeting ability) that are being applied in the therapy and diagnostic (theranostics). Overall, this review can give a glimpse into every aspect of PNPs, from their synthesis to drug delivery application for cancer cells.

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Section: Application In Cancer Treatmentmentioning

confidence: 99%

RETRACTED: An Overview of Polymeric Nanoparticles-Based Drug Delivery System in Cancer Treatment

Dristant

Mukherjee

Saha

et al. 2023

Technol Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…(Figure 1) [72]. Yan et al used polyethylene glycol-based polymers (α-lipoic acid) and the mPEG-α-PLA copolymer to construct a double-reduction/pH response nanocarrier for capsaicin (CAP) and doxorubicin (DOX) [73]. Zeng et al designed a dual-drug-loading nanosystem (named a THCD NP) that could selectively transport and target tumor cells for the treatment of cancer [74].…”

Section: Research Progress On Dual-drug-delivery Nano-theranostic Age...mentioning

confidence: 99%

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

Han,

Du,

Zhu

et al. 2023

Molecules

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Liver cancer has high incidence and mortality rates and its treatment generally requires the use of a combination treatment strategy. Therefore, the early detection and diagnosis of liver cancer is crucial to achieving the best treatment effect. In addition, it is imperative to explore multimodal combination therapy for liver cancer treatment and the synergistic effect of two liver cancer treatment drugs while preventing drug resistance and drug side effects to maximize the achievable therapeutic effect. Gold nanoparticles are used widely in applications related to optical imaging, CT imaging, MRI imaging, biomarkers, targeted drug therapy, etc., and serve as an advanced platform for integrated application in the nano-diagnosis and treatment of diseases. Dual-drug-delivery nano-diagnostic and therapeutic agents have drawn great interest in current times. Therefore, the present report aims to review the effectiveness of dual-drug-delivery nano-diagnostic and therapeutic agents in the field of anti-tumor therapy from the particular perspective of liver cancer diagnosis and treatment.

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One-pot, sustainable and room temperature synthesis of graphene oxide-impregnated iron-based metal-organic framework (GO/MIL-100(Fe)) nanocarriers for anticancer drug delivery systems

et al. 2022

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Engineering of combination drug delivery of pH/reduction response potential nanocarrier for the treatment of liver cancer

Cited by 11 publications

References 58 publications

RETRACTED: An Overview of Polymeric Nanoparticles-Based Drug Delivery System in Cancer Treatment

RETRACTED: An Overview of Polymeric Nanoparticles-Based Drug Delivery System in Cancer Treatment

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

One-pot, sustainable and room temperature synthesis of graphene oxide-impregnated iron-based metal-organic framework (GO/MIL-100(Fe)) nanocarriers for anticancer drug delivery systems

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