Abstract:The interaction sites between endoplasmic reticulum (ER) and mitochondria are signaling hubs in the cell implicated in calcium transfer, lipid metabolism, autophagy, and cell death among other functions. Transmission electron microscopy (TEM) is commonly used to visualize the geometry of these interfaces, but metrics used to describe and compare between conditions, as well as the techniques of measurement are not standardized. Here we describe a pair of scripts for ImageJ that allow for rapid, reproducible and… Show more
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