Engineering of Biocatalysts and Biocatalytic Processes

Lima-Ramos, Joana; Neto, Watson Lima Afonso; Woodley, John M.

doi:10.1007/s11244-013-0185-0

Cited by 49 publications

(37 citation statements)

References 117 publications

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“…Consequently, several attempts either for immobilization of BVMO expressing whole-cells or isolated enzymes have been investigated to improve overall biocatalyst stability. Such immobilization strategies may render improvements regarding increase of harvested product per cell mass, which is still challenging task at a larger scale BV oxidations (Lima-Ramos et al 2014).…”

Section: Immobilizationmentioning

confidence: 99%

Baeyer-Villiger oxidations: biotechnological approach

Bučko

Gemeiner

Schenkmayerová

et al. 2016

Appl Microbiol Biotechnol

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Baeyer-Villiger monooxygenases (BVMOs) are a very well-known and intensively studied class of flavin-dependent enzymes. Their substrate promiscuity, high chemo-, regio-, and enantioselectivity are prerequisites for the use in synthetic chemistry and should pave the way for successful industrial processes. Nonetheless, only a very limited number of industrial relevant transformations are known, mainly due to the lack of BVMOs stability and cofactor dependency. In this review, we focus on novel BVMO-mediated transformations, BVMOs in cascade type reactions, potential industrial applications, and how limitations have been tackled by the community. Special attention will be put on whole-cell immobilization strategies. We emphasize to bridge recent developments in fundamental research to industrial applications.

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Section: Immobilizationmentioning

confidence: 99%

Baeyer-Villiger oxidations: biotechnological approach

Bučko

Gemeiner

Schenkmayerová

et al. 2016

Appl Microbiol Biotechnol

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“…[20,21] In a recent review, the approach was further outlined and integration emphasized. [116] 3.9.5.2…”

Section: Methods Of Intensification Prior To Scale-upmentioning

confidence: 99%

3.9 Scale-Up and Development of Enzyme-Based Processes for Large-Scale Synthesis Applications

Faber¹,

Fessner²,

Turner³

2015

Biocatalysis in Organic Synthesis 3

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“…In the course of an increased interest in sustainable solutions, biotechnology offers alternative capabilities to the chemical production of valuable substances and elimination of contaminated sites [28][29][30]. Basically, biotechnological processes may be operated batch-wise, fed-batch-wise or in continuous flow.…”

Section: Biofilms In Biotechnologymentioning

confidence: 99%

Biotechnology and Bioprocess Engineering – From the First Ullmann's Article to Recent Trends

et al. 2015

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For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed.

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Engineering of Biocatalysts and Biocatalytic Processes

Cited by 49 publications

References 117 publications

Baeyer-Villiger oxidations: biotechnological approach

Baeyer-Villiger oxidations: biotechnological approach

3.9 Scale-Up and Development of Enzyme-Based Processes for Large-Scale Synthesis Applications

Biotechnology and Bioprocess Engineering – From the First Ullmann's Article to Recent Trends

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