Engineering of a Hollow‐Structured Cu_2−XS Nano‐Homojunction Platform for Near Infrared‐Triggered Infected Wound Healing and Cancer Therapy

Abstract

Infection and malignant tumors are the most common diseases in people's daily life, which seriously threaten human health. Because of the frequent and extensive administration of antibiotics and chemodrugs, the prevalence of multidrug-resistant bacteria and tumor cells makes the conventional therapies less effective and even invalid. To overcome the repugnant dilemma, herein the authors devise and develop a hollow Cu 2−X S nano-homojunction (nano-HJ) platform for the effective eradication of both bacteria and tumors upon tissue-penetrable near-infrared (NIR) light irradiation. Hyaluronan (HA) is covalently decorated onto the nano-homojunctions (nano-HJs) surface to enhance their biocompatibility, tumor-targeting ability, and cutaneous wound healing capability. The decorated nano-HJs exert robust NIR-activatable bactericidal modality and accelerate the cutaneous regeneration of bacteria-invaded full-thickness wounds through the synergy of photothermal/photodynamic effects, glutathione depletion, and HA assistance. After loading anticancer drug doxorubicin in the cavity of nano-HJs, the antitumor therapy efficacy is greatly strengthened both in vitro and in vivo by the collaborative photochemotherapy. Accordingly, this work not only highlights the great promise of the Cu 2−X S nano-HJs in the treatment of bacteria-induced contagious diseases and malignant tumors but also opens up a new research direction for the biomedical application of homojunction nanoplatforms in the future.

Near-infrared II plasmonic porous cubic nanoshells for in vivo noninvasive SERS visualization of sub-millimeter microtumors

“…6b that the resected tumor exhibits intense yet quite uniform SERS signal over the entire tumor, and the SERS image can depict clear demarcation of the resected tumor. Significant CD44 overexpression on the cell membrane of 4T1 breast cancer cells has been previously confirmed and extensively employed for the development of targeting drug delivery systems 45,[49][50][51] . The effective tumor accumulation of NIR-II SERS probes may be attributed to the combination of the passive enhanced permeability and retention (EPR) effect and the active targeting of CD44 overexpressed on the 4T1 tumor cells 1,45,51,52 .…”

“…Significant CD44 overexpression on the cell membrane of 4T1 breast cancer cells has been previously confirmed and extensively employed for the development of targeting drug delivery systems 45,[49][50][51] . The effective tumor accumulation of NIR-II SERS probes may be attributed to the combination of the passive enhanced permeability and retention (EPR) effect and the active targeting of CD44 overexpressed on the 4T1 tumor cells 1,45,51,52 . We further examined the suitability of our NIR-II SERS probes for in vivo NIR-II SERS imaging of a tumor in a 4T1 tumor-bearing mouse.…”

Multi-activity cobalt ferrite/MXene nanoenzymes for drug-free phototherapy in bacterial infection treatment

“…18 Another mechanism for sterilization without antibiotics is phototherapy, which focuses on the light-triggered bactericidal process. 19,20 Local hyperthermia-related photothermal therapy (PTT) and reactive oxygen species (ROS), containing superoxide radical (cO 2…”

“…18 Another mechanism for sterilization without antibiotics is phototherapy, which focuses on the light-triggered bactericidal process. 19,20 Local hyperthermia-related photothermal therapy (PTT) and reactive oxygen species (ROS), containing superoxide radical (˙O 2 − ), hydroxyl radicals (˙OH), and singlet oxygen ( 1 O 2 ), relevant photodynamic therapy (PDT) are two primary types of phototherapies. PTT depends on photothermal transfer agents for the generation of hyperthermia in a particular area to kill bacteria.…”

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

“…105 Furthermore, upon NIR excitation, black TiO 2 NPs and Cu 2Àx S NPs could also generate abundant ROS. 106,107 Notably, some multi-metallic compound-based nanomaterials have also been demonstrated to have excellent photosensitive activity, such as Bi 2 WO 6 nanosheets, 108 CuMo 2 S 3 nanocrystals 109 and CuInS 2 /ZnS core-shell nanocrystals. 110 Owing to its non-invasive, inexpensive and practical properties, light has attracted great interest as an exogenous stimulus for drug delivery nano-systems.…”