Engineering Natural Pollen Grains as Multifunctional 3D Printing Materials (Adv. Funct. Mater. 49/2021)

Chen, Shengyang; Shi, Qian; Jang, Tae‐Sik; Ibrahim, M. S.; Deng, Jingyu; Ferracci, Gaia; Tan, Wen See; Cho, Nam‐Joon; Song, Jiajia

doi:10.1002/adfm.202170360

Cited by 7 publications

(7 citation statements)

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“…In addition, biocompatible materials that do not trigger allergic or toxic reactions are widely used in 3D printing, but the rheological properties of the materials are also critical to the performance of the scaffolds used. [ 15 ] Hydrogel has been widely used as a multifunctional biomaterial for in vitro tissue organ fabrication because of its good biocompatibility and biodegradability. It demonstrates properties similar to those of natural ECM.…”

Section: Methodsmentioning

confidence: 99%

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Toward Efficient Cartilage Disease Management with Additive Manufacturing: Monitoring, Cell Culture, and Drug Release

Dong,

Shao,

Gao

et al. 2023

Advanced Sensor Research

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Articular cartilage damage is often caused by joint disease, trauma, and aging in everyday life. Cartilage damage usually refers to some changes in the normal structure and a gradual loss of function. Local discomforts, such as slight swelling or pain, may occur. Due to the lack of blood vessels and nerves in articular cartilage, articular cartilage damage is difficult to repair, making the detection and repair of articular cartilage damage difficult. New detection and repair technologies are urgently needed. The existing treatment methods are often used to monitor the internal environment and repair cartilage by implanting stents. Due to its high precision and simulation, 3D printing has shown great potential in carrier drug refinement and detection sensing and has become one of the more ideal technologies in the biomedical field. This article reviews the mitigation measures of bone injury, 3D printing technology, and treatment strategies for bone injury based on 3D printing technology. In addition, some challenges and possible solutions are also put forward for the treatment of bone injuries, as well as some possible development directions in the future.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Toward Efficient Cartilage Disease Management with Additive Manufacturing: Monitoring, Cell Culture, and Drug Release

Dong,

Shao,

Gao

et al. 2023

Advanced Sensor Research

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“…The process was rapidly repeated, eventually yielding a femur‐specific orthopedic implant. [ 48 ] Subsequently, the composite implants were fabricated using PEEK filaments reinforced with different amounts of TiO 2 nanoparticles. The polydopamine derivatives, unreacted dopamine, and any impurities, which can cause unexpected metabolic disorders and neural system malfunctions, were degraded under a high‐temperature heat treatment, leaving only the TiO 2 reinforcement and PEEK matrix.…”

Section: Methodsmentioning

confidence: 99%

Topography‐Supported Nanoarchitectonics of Hybrid Scaffold for Systematically Modulated Bone Regeneration and Remodeling

Jang

Park

Lee

et al. 2022

Adv Funct Materials

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Orthopedic implants should have sufficient strength and promote bone tissue regeneration. However, most conventional implants are optimized for use either under high mechanical load or for active osseointegration. To achieve the dual target of mechanical durability and biocompatibility, polyether ether ketone (PEEK) filaments reinforced with internal titanium dioxide (TiO2) nanoparticles via dopamine‐induced polymerization are additively manufactured into an orthopedic implant through material extrusion (ME). The exterior of the PEEK/TiO2 composite is coated with hydroxyapatite (HA) using radiofrequency (RF) magnetron sputtering to increase both the strength and biocompatibility provided by homogeneous ceramic–ceramic interactions and the protuberant nanoscale topography between the internal TiO2 nanoparticle reinforcement and external HA coating. The hardness, tensile, and compression, and scratch test results demonstrate a considerable enhancement in the mechanical strength of the hierarchical PEEK/TiO2/HA hybrid composite structure compared to that of the conventional 3D‐printed PEEK. Furthermore, PEEK with internal TiO2 reinforcement improves the proliferation and differentiation of bone cells in vitro, whereas the external HA coating leads to a more prevalent osteoblast absorption. Micro‐computed tomography and histological analyses confirm new bone formation and a high bone‐to‐implant contact ratio on the HA‐coated PEEK structure reinforced with TiO2 nanoparticles.

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“…However, the hollow internal shells of pollen microparticles can be used for cargo encapsulation and delivery recently reported by our previous research. [ 32–37 ] Moreover, pollen microparticles have been used as 3D scaffolds, [ 38 ] paper derived from pollen microgels, [ 39 ] pressure sensors, [ 40 ] biosensor platform, [ 41 ] flexible pollen‐derived substrate for optoelectronic applications, [ 42 ] and water cleaning. [ 17,18,43 ]…”

Section: Introductionmentioning

confidence: 99%

Pollen‐Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells

Mayorga‐Martinez

Fojtů

Vyskočil

et al. 2022

Adv Funct Materials

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Naturally occurring micro/nanoparticles provide an incredible array of potential sources when preparing hybrid micro/nanorobots and their intrinsic properties can be exploited as multitasking functionalities of modern robotics as well as ensuring their mass production availability. Herein, magnetic biological bots (BioBots) prepared from defatted sunflower pollen microparticles by ferromagnetic metal layer evaporation on one side of its surface are described. It is demonstrated that the methodology employed introduces magnetic properties to sunflower pollen microparticles-based Bio-Bots and enable their magnetic actuation. Interestingly, as-prepared magnetic sunflower pollen-based BioBots can naturally attract cancer cells due to their opposite charges (positive and negative, respectively). Such attracted cancer cells can then be transported by microrobots. This strong attraction also allows the delivery of drugs intended to kill the cancer cells. Sunflower-based BioBots can be fabricated in large quantities, and are naturally programmable, making them promising candidates for cancer cell therapy.

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Engineering Natural Pollen Grains as Multifunctional 3D Printing Materials (Adv. Funct. Mater. 49/2021)

Cited by 7 publications

References 0 publications

Toward Efficient Cartilage Disease Management with Additive Manufacturing: Monitoring, Cell Culture, and Drug Release

Toward Efficient Cartilage Disease Management with Additive Manufacturing: Monitoring, Cell Culture, and Drug Release

Topography‐Supported Nanoarchitectonics of Hybrid Scaffold for Systematically Modulated Bone Regeneration and Remodeling

Pollen‐Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells

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