Engineering natural matrices with black phosphorus nanosheets to generate multi-functional therapeutic nanocomposite hydrogels

Miao, Yali; Shi, Xuetao; Li, Qingtao; Li, Hao; Liu, Lei; Liu, Xiao; Chen, Yunhua; Wang, Yingjun

doi:10.1039/c9bm01072f

Cited by 71 publications

(59 citation statements)

References 50 publications

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“…The d-spacing of lattice fringes in BPNSs and BP@BMP 2 nanosheets photographed by HR-TEM was 0.28 and 0.25 nm respectively ( Figure 1E,G), as expected in a typical BPNS structure. [29,[34][35][36] XPS (Kratos, AXIS Ultra DLD) results demonstrated that the P2p and P2s peaks of BPNSs located at about 130 and 200 eV, consisting with the standard peak reported by previous study, which confirmed the successful preparation of BPNSs. [33] Furthermore, BP@BMP 2 nanosheets exhibited high carbon, oxygen, and nitrogen concentration and the standard P2p and P2s peaks, which demonstrated that the successful modification of BMP 2 ( Figure 1H; Figure S2, Supporting Information).…”

Section: Characterization Of Bp@bmp 2 Nanosheetssupporting

confidence: 79%

Bioinspired Functional Black Phosphorus Electrospun Fibers Achieving Recruitment and Biomineralization for Staged Bone Regeneration

Cheng

Chen

Cai

et al. 2020

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The ideal bone repair material should firstly recognize and recruit osteoblast precursor cells to initiate the repair process, then promote the differentiation of osteoblasts and accelerate the mineralization of the extracellular matrix (ECM). Here, a bioinspired staged bone regeneration strategy which loads bone morphogenetic protein2 (BMP2)‐modified black phosphorus (BP@BMP2) nanosheets to a polylactic acid (PLLA) electrospun fibrous scaffold, with a combination of recruiting osteoblast precursor cells and biomineralization properties for bone regeneration, is constructed successfully by micro‐sol electrospinning technique. BP, acting as carriers, can not only provide a negative surface and a strong BMP2 loading ability but can also promote biomineralization in a 3D manner on the electrospun fibrous scaffold, while the BMP2 is to target osteoblast precursor cells for recruitment and osteogenesis differentiation, which endows BP@BMP2 nanosheets with staged bone regeneration ability. Furthermore, the in vitro and in vivo data showed that the BP@BMP2 loaded electrospun fibrous scaffold have good biocompatibility and a strong osteogenesis ability resulting in rapid new bone tissue regeneration. Altogether, this newly developed bioinspired BMP2‐modified BP electrospun fiber with staged bone regeneration properties via recruiting osteoblast precursor cells to the bone injured site and accelerating biomineralization can be a promising approach in physiologic bone repair.

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Section: Characterization Of Bp@bmp 2 Nanosheetssupporting

confidence: 79%

Bioinspired Functional Black Phosphorus Electrospun Fibers Achieving Recruitment and Biomineralization for Staged Bone Regeneration

Cheng

Chen

Cai

et al. 2020

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“…RNA sequencing analysis demonstrated that the Wnt signaling pathway was involved in in situ bone regeneration. Moreover, a new class of 2D BP nanosheets have been employed as photothermal agents for the remote control of bone regeneration 106 , 107 . These BP nanosheets could upregulate the expression of heat shock proteins in human BMSCs and thus enhance bone tissue regeneration by remote control of NIR light irradiation.…”

Section: Discussionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.

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“…115 To simultaneously combat infection and improve bone regeneration, a multi-functional, therapeutic, BP-based hydrogel nanocomposite was designed. 116 Upon NIR irradiation, the nanocomposite hydrogel demonstrated efficient photothermal antibacterial features ( Figure 6A and B). What's more, this nanocomposite hydrogel can promote osteogenesis in the absence of osteoinductive factors in vitro, and in the meantime induce newborn cranial bone tissue formation ( Figure 6C).…”

Section: -mentioning

confidence: 99%

<p>Advanced Black Phosphorus Nanomaterials for Bone Regeneration</p>

Qing

et al. 2020

IJN

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Bone regeneration remains a great clinical challenge. Two-dimensional materials, especially graphene and its derivative graphene oxide, have been widely used for bone regeneration. Since its discovery in 2014, black phosphorus (BP) nanomaterials including BP nanosheets and BP quantum dots have attracted considerable scientific attention and are considered as prospective graphene substitutes. BP nanomaterials exhibit numerous advantages such as excellent optical and mechanical properties, electrical conductivity, excellent biocompatibility, and good biodegradation, all of which make them particularly attractive in biomedicine. In this review, we comprehensively summarize recent advances of BP-based nanomaterials in bone regeneration. The advantages are reviewed, the different synthesis methods of BP are summarized, and the applications to promote bone regeneration are highlighted. Finally, the existing challenges and perspectives of BP in bone regeneration are briefly discussed.

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Engineering natural matrices with black phosphorus nanosheets to generate multi-functional therapeutic nanocomposite hydrogels

Abstract: Natural matrices are engineered with black phosphorus nanosheets to generate therapeutic nanocomposite hydrogels with promising multi-functions, providing a facile and efficient therapeutic strategy for bone tissue engineering.

Cited by 71 publications

References 50 publications

Bioinspired Functional Black Phosphorus Electrospun Fibers Achieving Recruitment and Biomineralization for Staged Bone Regeneration

Bioinspired Functional Black Phosphorus Electrospun Fibers Achieving Recruitment and Biomineralization for Staged Bone Regeneration

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

<p>Advanced Black Phosphorus Nanomaterials for Bone Regeneration</p>

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