Engineering nanoparticle strategies for effective cancer immunotherapy

Yoon, Hong Yeol; Selvan, Subramanian Tamil; Yang, Yoosoo; Kim, Min Ju; Yi, Dong Kee; Kwon, Ick Chan; Kim, Kwangmeyung

doi:10.1016/j.biomaterials.2018.03.036

Cited by 125 publications

(87 citation statements)

References 101 publications

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“…[222] The concept of ICD proposed in recent years demonstrates that dying tumor cells (DTCs) can generate a mass of antigens and increase the generation of damage associated molecular patterns (DAMPs), such as adenosine triphosphate, CRT, heat shock proteins, and high mobility group box-1. [224] More importantly, ICD-derived tumor antigens can be manipulated by immune system and pose threat to abscopal and metastatic tumors, referred to as "abscopal effect." [224] More importantly, ICD-derived tumor antigens can be manipulated by immune system and pose threat to abscopal and metastatic tumors, referred to as "abscopal effect."…”

Section: Combination Of Immunotherapy and Traditional Managementsmentioning

confidence: 99%

Immunomodulatory Nanosystems

et al. 2019

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Immunotherapy has emerged as an effective strategy for the prevention and treatment of a variety of diseases, including cancer, infectious diseases, inflammatory diseases, and autoimmune diseases. Immunomodulatory nanosystems can readily improve the therapeutic effects and simultaneously overcome many obstacles facing the treatment method, such as inadequate immune stimulation, off‐target side effects, and bioactivity loss of immune agents during circulation. In recent years, researchers have continuously developed nanomaterials with new structures, properties, and functions. This Review provides the most recent advances of nanotechnology for immunostimulation and immunosuppression. In cancer immunotherapy, nanosystems play an essential role in immune cell activation and tumor microenvironment modulation, as well as combination with other antitumor approaches. In infectious diseases, many encouraging outcomes from using nanomaterial vaccines against viral and bacterial infections have been reported. In addition, nanoparticles also potentiate the effects of immunosuppressive immune cells for the treatment of inflammatory and autoimmune diseases. Finally, the challenges and prospects of applying nanotechnology to modulate immunotherapy are discussed.

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Section: Combination Of Immunotherapy and Traditional Managementsmentioning

confidence: 99%

Immunomodulatory Nanosystems

et al. 2019

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“…For effective tumor immunotherapy, NP-based systems may combine different treatment modalities, such as chemotherapy, photodynamic therapy (PDT) and hyperthermia, as an effective therapeutic strategy. [61][62][63][64][65] Wang et al 54 Combined PD-L1 knockdown and PDT completely eliminated the B16-F10 tumors ( Figure 2E). Moreover, combined immunotherapy markedly suppressed the metastasis of B16-F10 in the lungs ( Figure 2F).…”

Section: Tumor Microenvironment-targeted Rna Interference Strategy mentioning

confidence: 91%

“…For effective tumor immunotherapy, NP‐based systems may combine different treatment modalities, such as chemotherapy, photodynamic therapy (PDT) and hyperthermia, as an effective therapeutic strategy . Wang et al .…”

Section: Tumor Microenvironment‐targeted Rna Interference Strategy Fomentioning

confidence: 99%

Non‐viral gene delivery for cancer immunotherapy

Wang

Saeed

Zhou

et al. 2019

The Journal of Gene Medicine

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Recent decades have witnessed the revolutionary development of cancer immunotherapies, which boost cancer‐specific immune responses for long‐term tumor regression. However, immunotherapy still has limitations, including off‐target side effects, long processing times and limited patient responses. These disadvantages of current immunotherapy are being addressed by improving our understanding of the immune system, as well as by establishing combinational approaches. Advanced biomaterials and gene delivery systems overcome some of these delivery issues, harnessing adverse effects and amplifying immunomodulatory effects, and are superior to standard formulations with respect to eliciting antitumor immunity. Nucleic acid‐based nanostructures have diverse functions, ranging from gene expression and gene regulation to pro‐inflammatory effects, as well as the ability to specifically bind different molecules. A brief overview is provided of the recent advances in the non‐viral gene delivery methods that are being used to activate cancer‐specific immune responses. Furthermore, the tumor microenvironment‐responsive synergistic strategies that modulate the immune response by targeting various signaling pathways are discussed. Nanoparticle‐based non‐viral gene delivery strategies have great potential to be implemented in the clinic for cancer immunotherapy.

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“…ACT has been developed to change CTLs to an antigen‐specific phenotype ex vivo, then expand it, and finally inject it back into patients to attack and kill cancer cells. However, these strategies also have their drawbacks . For example, efficient cross‐presentation to induce strong and durable antitumor immune response is challenging in the design of cancer vaccines.…”

Section: Immunological Tolerance In Tumormentioning

confidence: 99%

“…As a delivery vehicle, nanomaterials can enhance cancer treatment by protecting drugs from degradation, and alter the pathways in cell uptake, in vivo distribution, metabolism, and clearance to enhance the effectiveness and decrease the side effects of drugs . Nanomaterials can enhance antigen presentation in antigen‐presenting cells (APCs) to induce antigen‐specific cytotoxic T lymphocyte (CTL) response and regulate the immune‐inhibitory tumor microenvironment (TME) by delivering cytokines and antibodies . In this paper, we first briefly introduce the subject of tumor immunological tolerance and then summarize the advantages of nanomaterials in immunotherapy application.…”

Section: Introductionmentioning

confidence: 99%

Functional Nanomaterials Optimized to Circumvent Tumor Immunological Tolerance

Gong

Zhang

et al. 2018

Adv Funct Materials

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Advances in cancer immunology have revealed that immunological tolerance, which is characterized by low immunogenicity, insufficient antigen presentation, and low T lymphocyte infiltration, increases the expression of inhibitory receptors and cytokines in tumors. These features make it possible for tumor cells to easily escape attack by immune cells. Nanomaterials, with unique properties such as ultrasmall size, unique surface characteristics, and multivalent effects, have attracted an increasing amount of attention in the regulation of the immunological microenvironment of tumors. In this review, the use of functional nanomaterials to reverse immunological tolerance in tumors is examined, including the use of nanomaterials for efficient cancer vaccines, checkpoint blockade delivery, cytokine delivery, artificial antigen presentation cells, and adoptive cell therapy. The benefits and challenges of using nanomaterials to circumvent the immunological tolerance of tumors are also discussed.

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Engineering nanoparticle strategies for effective cancer immunotherapy

Cited by 125 publications

References 101 publications

Immunomodulatory Nanosystems

Immunomodulatory Nanosystems

Non‐viral gene delivery for cancer immunotherapy

Functional Nanomaterials Optimized to Circumvent Tumor Immunological Tolerance

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