Engineering nanocellulose hydrogels for biomedical applications

Curvello, Rodrigo; Raghuwanshi, Vikram Singh; Garnier, Gil

doi:10.1016/j.cis.2019.03.002

Cited by 326 publications

(203 citation statements)

References 160 publications

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“…Among possible natural-derived polymers used for the production of hydrogels for biomedical applications, cellulose nanofibers (CNFs) have emerged as an outstanding alternative, thanks to the high availability, low cost and good biocompatibility of cellulose [16][17][18][19][20]. A suitable method for the preparation of CNFs is based on the regioselective oxidation of the primary hydroxyls of cellulose to corresponding carboxylic groups, catalyzed by 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) in the presence of an NaBr/NaClO oxidizing system.…”

Section: Introductionmentioning

confidence: 99%

TEMPO-Nanocellulose/Ca2+ Hydrogels: Ibuprofen Drug Diffusion and In Vitro Cytocompatibility

et al. 2020

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Stable hydrogels with tunable rheological properties were prepared by adding Ca2+ ions to aqueous dispersions of 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)-oxidized and ultra-sonicated cellulose nanofibers (TOUS-CNFs). The gelation occurred by interaction among polyvalent cations and the carboxylic units introduced on TOUS-CNFs during the oxidation process. Both dynamic viscosity values and pseudoplastic rheological behaviour increased by increasing the Ca2+ concentration, confirming the cross-linking action of the bivalent cation. The hydrogels were proved to be suitable controlled release systems by measuring the diffusion coefficient of a drug model (ibuprofen, IB) by high-resolution magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy. IB was used both as free molecule and as a 1:1 pre-formed complex with β-cyclodextrin (IB/β-CD), showing in this latter case a lower diffusion coefficient. Finally, the cytocompatibility of the TOUS-CNFs/Ca2+ hydrogels was demonstrated in vitro by indirect and direct tests conducted on a L929 murine fibroblast cell line, achieving a percentage number of viable cells after 7 days higher than 70%.

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Section: Introductionmentioning

confidence: 99%

TEMPO-Nanocellulose/Ca2+ Hydrogels: Ibuprofen Drug Diffusion and In Vitro Cytocompatibility

et al. 2020

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“…This results in a different mechanism of gel network formation, which includes entanglement of NC particles or fibers followed by physical or chemical crosslinking. 153 However, CNCs themselves lack the entanglement ability and more often are employed as fillers in gel composite structures due to their mechanical properties. In these composite hydrogels, the interaction of CNCs with loaded molecules (drugs) usually does not affect the loading and release characteristics but significantly improves the mechanical and chemical stability of the hydrogels.…”

Section: Cellulose-based Materialsmentioning

confidence: 99%

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

et al. 2020

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“…The hydrogel degradation within the body can proceed via hydrolytical or enzymatical mechanisms in which the erosion of the scaffold occurs in bulk or at the surface of the hydrogel (Curvello et al, 2019). Bulk erosion is the predominant mechanism of hydrogel biodegradation which is attributable to the permeability and large water content present in hydrogels.…”

Section: Tailored Hydrogels For Tissue Engineeringmentioning

confidence: 99%

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

et al. 2020

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Since the introduction of tissue engineering as an encouraging method for the repair and regeneration of injured tissue, there have been many attempts by researchers to construct bio-mimetic scaffolds which mimic the native extracellular matrix, with the aim of promoting cell growth, cell proliferation, and restoration of the tissue's native functionality. Among the different materials and methods of scaffold fabrication, one particularly promising class of materials, hydrogels, has been extensively studied, with the inclusion of nano-scaled materials into hydrogels leading to the creation of an exciting new generation of nanocomposites, known as nanocomposite hydrogels. To closely mimic the native tissue behavior, scientists have recently focused on the functionalization of incorporated nanomaterials via chiral biomolecules, with reported results showing great potential. The current article aims to introduce a perspective of nano-scaled cellulose as a promising nanomaterial which can be multi-functionalized for the fabrication of nanocomposite hydrogels with applications in tissue engineering and drug delivery systems. This article also briefly reviews the recently reported literature on nanocomposite hydrogels incorporated with chiral functionalized nanomaterials. Such knowledge paves the path for the development of tailored hydrogels toward practical applications.

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Engineering nanocellulose hydrogels for biomedical applications

Cited by 326 publications

References 160 publications

TEMPO-Nanocellulose/Ca2+ Hydrogels: Ibuprofen Drug Diffusion and In Vitro Cytocompatibility

TEMPO-Nanocellulose/Ca2+ Hydrogels: Ibuprofen Drug Diffusion and In Vitro Cytocompatibility

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

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