Engineering Multifunctional Capsules through the Assembly of Metal–Phenolic Networks

Abstract

Metal-organic coordination materials are of widespread interest because of the coupled benefits of inorganic and organic building blocks. These materials can be assembled into hollow capsules with a range of properties, which include selective permeability, enhanced mechanical/thermal stability, and stimuli-responsiveness. Previous studies have primarily focused on the assembly aspects of metal-coordination capsules; however, the engineering of metal-specific functionality for capsule design has not been explored. A library of functional metal-phenolic network (MPN) capsules prepared from a phenolic ligand (tannic acid) and a range of metals is reported. The properties of the MPN capsules are determined by the coordinated metals, allowing for control over film thickness, disassembly characteristics, and fluorescence behavior. Furthermore, the functional properties of the MPN capsules were tailored for drug delivery, positron emission tomography (PET), magnetic resonance imaging (MRI), and catalysis. The ability to incorporate multiple metals into MPN capsules demonstrates that a diverse range of functional materials can be generated.

Soluble Porous Coordination Polymers by Mechanochemistry: From Metal‐Containing Films/Membranes to Active Catalysts for Aerobic Oxidation

“…[b] SPCP-Fe 85 7 -90 7 [b] SPCP-Fe(Reuse) 82 5 -91 8 [b] SPCP-Fe(Reuse) 89 7 -91 9 [b] SPCP-Fe ( For example, our ongoing experiment showed that mimosa tannin, a ubiquitous and cheap polyphenol biomass with diverse chelation sites and a relatively rigid backbone, can be facilely coordinated with Zn 2+ ions for well-defi ned mesoporous polymers ( S BET = 154 m 2 g -1 ) with pore sizes of around 10 nm, and these mesoporous channels are highly desired in heterogeneous catalysis ( Figure 4 ). [ 11 ] Moreover, the rapid, solventfree solid synthesis by ball grinding once again highlights the promising potential of mechanochemistry in nanostructure formation, thus presenting a sustainable alternative to classical solution-based synthesis.…”

Magnetic Core–Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery

“…In contrast to previous carrier coating strategies using lipid bilayer or cationic polymers, [ 4,8,30,41 ] this TA coating has been featured by high biocompatibility, availability to various substrates, facile one-step preparation and pH-dependent decomposition. [ 40,42,43 ] In this study, the successful coating of TA onto the nanoparticles is fi rst confi rmed by FTIR, X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis ( Figure S7, Supporting Information). The TA coated sample shows additional C-H adsorption peaks in 1300-1500 cm −1 range of FTIR spectrum.…”

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

“…The template was dissolved in a typical way and monodisperse DOX-loaded MPN capsules (DOX-Al Topotecan, Verapamil) can also be loaded within MPN capsules by using this method. The ability to incorporate multiple metals into MPN capsules demonstrates their diverse applications including drug delivery, positron emission tomography (PET), magnetic resonance imaging (MRI), biomedical imaging and catalysis [358]. Furthermore, a synthetic PEG-polyphenol derivative was prepared as a result of the PEG-NHS reaction with dopamine hydrochloride and then used it as a building layer [359].…”