2015
DOI: 10.1007/s00262-015-1688-2
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Engineering monocyte-derived dendritic cells to secrete interferon-α enhances their ability to promote adaptive and innate anti-tumor immune effector functions

Abstract: Dendritic cell (DC) vaccination has demonstrated potential in clinical trials as a new effective cancer treatment, but objective and durable clinical responses are confined to a minority of patients. Interferon (IFN)-α, a type-I IFN, can bolster anti-tumor immunity by restoring or increasing the function of DCs, T cells and natural killer (NK) cells. Moreover, type-I IFN signaling on DCs was found to be essential in mice for tumor rejection by the innate and adaptive immune system. Targeted delivery of IFN-α b… Show more

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Cited by 30 publications
(26 citation statements)
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References 48 publications
(62 reference statements)
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“…[105][106][107][108][109][110] Accordingly, RCD can no longer be perceived as immunogenic when: (1) the intracellular stress responses regulating the emission of ICD-associated DAMPs are pharmacologically or genetically ablated in cancer cells; or (2) when the molecular machinery dedicated to DAMP detection is inhibited or ablated. 13,44,84,91,93,97 Moreover, ICD-driven immunity can no longer operate in the presence of general immunological defects, 111 such as (1) an intrinsically low antigenicity of cancer cells, owing to low levels of TAAs or downregulation of MHC Class I molecules [112][113][114][115][116][117][118][119] ; (2) an increased immunological tolerance of the host, secondary to increased amounts of immunosuppressive cytokines, [120][121][122][123][124][125][126][127][128] or inhibitors of chemotaxis, [129][130][131][132][133][134] increased tumor infiltration by immunosuppressive cell populations, [135][136][137][138][139][140]…”
Section: Introductionmentioning
confidence: 99%
“…[105][106][107][108][109][110] Accordingly, RCD can no longer be perceived as immunogenic when: (1) the intracellular stress responses regulating the emission of ICD-associated DAMPs are pharmacologically or genetically ablated in cancer cells; or (2) when the molecular machinery dedicated to DAMP detection is inhibited or ablated. 13,44,84,91,93,97 Moreover, ICD-driven immunity can no longer operate in the presence of general immunological defects, 111 such as (1) an intrinsically low antigenicity of cancer cells, owing to low levels of TAAs or downregulation of MHC Class I molecules [112][113][114][115][116][117][118][119] ; (2) an increased immunological tolerance of the host, secondary to increased amounts of immunosuppressive cytokines, [120][121][122][123][124][125][126][127][128] or inhibitors of chemotaxis, [129][130][131][132][133][134] increased tumor infiltration by immunosuppressive cell populations, [135][136][137][138][139][140]…”
Section: Introductionmentioning
confidence: 99%
“…DC were generated as described previously [25, 26] with minor adaptations specific for the IL-15 designer DC. Briefly, positively selected CD14 + monocytes were differentiated into immature DC in the presence of IL-4 (20 ng/mL; Life Technologies) and granulocyte-macrophage colony-stimulating factor (800 U/mL; Gentaur) in Roswell Park Memorial Institute 1640 (RPMI; Invitrogen) supplemented with 2.5% human AB serum (SanBio).…”
Section: Methodsmentioning
confidence: 99%
“…Immunohistochemistry of tumors for NK cell infiltration were performed as previously described [9, 13]. For NKG2D blocking, we used the C7 monoclonal antibody which reacts with the mouse NKG2D (eBioscience, San Diego CA, USA).…”
Section: Methodsmentioning
confidence: 99%