Engineering magnetic nanoparticles and their integration with microfluidics for cell isolation

Unni, Mythreyi; Zhang, Jinling; George, Thomas J.; Segal, Mark S.; Fan, Z. Hugh; Rinaldi, Carlos

doi:10.1016/j.jcis.2019.12.092

Cited by 27 publications

(14 citation statements)

References 46 publications

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“…Integrating microfluidics with isolation techniques can reduce the amount of reagents, increase isolation speed and allow automation 121 . Moreover, microfluidics can be introduced to rapidly mass-synthesize uniform magnetic particles 122 and to efficiently isolate viruses using magnetic-particle-based microfluidics 123 . In addition, DNA 124 or RNA nanostructures 125 that contain complementary oligonucleotides to virus DNA or RNA could be combined with microfluidics for virus isolation.…”

Section: Possibilities For Materials Sciencementioning

confidence: 99%

A materials-science perspective on tackling COVID-19

et al. 2020

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Section: Possibilities For Materials Sciencementioning

confidence: 99%

A materials-science perspective on tackling COVID-19

et al. 2020

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“…[237] Other examples of microfluidic systems that incorporate NPs are aimed toward isolation and characterization of rare target cells from a heterogeneous sample. [171,246] Rapid detection and isolation of rare cells is often achieved via basic ligandreceptor chemistry. [247,248] Additionally, antibody-functionalized superparamagnetic beads have been used to isolate rare cells from whole blood samples on microfluidic platforms.…”

Section: Nanoparticlesmentioning

confidence: 99%

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Welch

Powell

Clevinger

et al. 2021

Adv Funct Materials

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Nanoscale materials have unique properties that make them especially useful for biomedical diagnostic applications. Recent developments in nanoengineering have resulted in increasing use of nanostructures in biosensors. Various types of 0D, 1D, 2D, and 3D nanostructures have been used to improve biosensor sensitivity, selectivity, limit of detection, and time to result, among other metrics. These nanostructures have been integrated into electrochemical, optical, and other biosensors for this purpose. Here, the most recent advances in the use of nanostructured materials in biosensors are described. This includes a discussion of nanoparticles, nanorods, nanofibers, nanopillars, nanowires, nanosheets, indented nanopatterns (nanoholes and nanoslits), nanogaps, nanochannels, nanopores, nanofunctionalized surfaces, and complex hierarchical structures and their unique advantages and applications in biosensors. Clinical applications of these nanobiosensors are also highlighted along with a discussion of the future directions for these materials in diagnostics.

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“…In addition, microfluidics with the isolation techniques allows rapid detection of viruses with fewer amounts of reagents [ 26 ]. Magnetic particle-based microfluidics is also suggested to offer the isolation of viruses [ 27 ]. Rapid detection of viruses hinders its spread and therefore, materials coupled with immunoassays and PCR tests for nucleic acid amplification are reliable for on-site detection of viruses (Fig.…”

Section: Impact Of Materials Science Toward Countering Virusesmentioning

confidence: 99%

Recent advances in materials science: a reinforced approach toward challenges against COVID-19

et al. 2021

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With the recent COVID-19 pandemic, medical professionals and scientists have encountered an unprecedented trouble to make the latest technological solutions to work. Despite of abundant tools available as well as initiated for diagnosis and treatment, researchers in the healthcare systems were in backfoot to provide concrete answers to the demanding challenge of SARS-CoV-2. It has incited global collaborative efforts in every field from economic, social, and political to dedicated science to confront the growing demand toward solution to this outbreak. Field of materials science has been in the frontline to the current scenario to provide major diagnostic tools, antiviral materials, safety materials, and various therapeutic means such as, antiviral drug design, drug delivery, and vaccination. In the present article, we emphasized the role of materials science to the development of PPE kits such as protecting suits, gloves, and masks as well as disinfection of the surfaces/surroundings. In addition, contribution of materials science towards manufacturing diagnostic devices such as microfluidics, immunosensors as well as biomaterials with a point of care analysis has also been discussed. Further, the efficacy of nanoparticles and scaffolds for antiviral drug delivery and micro-physiological systems as well as materials derived from human tissues for extracorporeal membrane oxygenation (ECMO) devices have been elaborated towards therapeutic applications.

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Engineering magnetic nanoparticles and their integration with microfluidics for cell isolation

Cited by 27 publications

References 46 publications

A materials-science perspective on tackling COVID-19

A materials-science perspective on tackling COVID-19

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Recent advances in materials science: a reinforced approach toward challenges against COVID-19

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