Engineering Implantable Bioelectronics for Electrophysiological Monitoring in Preclinical Animal Models

Abstract

Implantable bioelectronics capable of electrophysiological monitoring intimately interfacing with biological tissue have provided massive information for profound understanding of biological systems. However, their invasive nature induces a potential risk of acute tissue damage, limiting accurate and chronic monitoring of electrophysiological signals. To address this issue, advanced studies have developed effective strategies to engineer the soft, flexible device using preclinical animal models. In addition, the optional but innovative approaches to improve the device’s function have been also explored. Here, we summarize these strategies satisfying essential and supplemental requirements for engineering implantable bioelectronics. Three types of implantable devices, classified by their structural designs, are introduced to describe the approaches using suitable strategies for their specific purpose. We conclude with the further advancement of engineering implantable bioelectronics to address the remaining challenges. Such advancements have the potential to contribute to enhanced functionality, encouraging a more delicate understanding of the physiology of biological systems and further broadening the applicability of implantable bioelectronics in the field of biomedical technology.This article is protected by copyright. All rights reserved.