Engineering hybrid nanosystems for efficient and targeted delivery against bacterial infections

Elhassan, Eman; Devnarain, Nikita; Mohammed, Mahir; Govender, Thirumala; Omolo, Calvin A.

doi:10.1016/j.jconrel.2022.09.052

Cited by 22 publications

(10 citation statements)

References 152 publications

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“…The core comprises a polymer encapsulating therapeutic substances surrounded by a lipid layer shell. [31][32][33] The lipid layer shell confers biocompatibility to the LPNPs and prevents the encapsulated contents from leaking. The stealthy PEGylated lipid on the surfaces can also enhance their in vivo circulation.…”

Section: Development Of Lipid-based Nanoparticlesmentioning

confidence: 99%

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticlesin vivo

Zhong

Zheng

et al. 2023

Biomater. Sci.

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Section: Development Of Lipid-based Nanoparticlesmentioning

confidence: 99%

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticlesin vivo

Zhong

Zheng

et al. 2023

Biomater. Sci.

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“…13 Focusing on the development of drug delivery nanoformulations, this integrative approach has been demonstrated to overcome the limitations of independent constituents, such as poor stability, premature cargo leakage before reaching the target, low biocompatibility, poor storage stability, and intolerable toxicity. 14 Hence, a wide variety of multicomponent nanosystems have been implemented for drug delivery, gene therapy, phototherapy, tissue regeneration, vaccines, biomolecule detection, cancer theranostics, and antibacterial therapy. 15−21 Over the last 20 years, organically modified mesoporous silica nanoparticles (MSNs) have been extensively exploited as drug delivery systems for a wide range of biomedical applications, 22−33 most recently including the treatment of bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

Organically Modified Mesoporous Silica Nanoparticles against Bacterial Resistance

Colilla,

Vallet-Regí

2023

Chem. Mater.

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Bacterial antimicrobial resistance is posed to become a major hazard to global health in the 21st century. An aggravating issue is the stalled antibiotic research pipeline, which requires the development of new therapeutic strategies to combat antibiotic-resistant infections. Nanotechnology has entered into this scenario bringing up the opportunity to use nanocarriers capable of transporting and delivering antimicrobials to the target site, overcoming bacterial resistant barriers. Among them, mesoporous silica nanoparticles (MSNs) are receiving growing attention due to their unique features, including large drug loading capacity, biocompatibility, tunable pore sizes and volumes, and functionalizable silanol-rich surface. This perspective article outlines the recent research advances in the design and development of organically modified MSNs to fight bacterial infections. First, a brief introduction to the different mechanisms of bacterial resistance is presented. Then, we review the recent scientific approaches to engineer multifunctional MSNs conceived as an assembly of inorganic and organic building blocks, against bacterial resistance. These elements include specific ligands to target planktonic bacteria, intracellular bacteria, or bacterial biofilm; stimuli-responsive entities to prevent antimicrobial cargo release before arriving at the target; imaging agents for diagnosis; additional constituents for synergistic combination antimicrobial therapies; and aims to improve the therapeutic outcomes. Finally, this manuscript addresses the current challenges and future perspectives on this hot research area.

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“…Recent advancements in using nanoparticles for delivery include targeted delivery ( Eskandani et al, 2022 ; Wu et al, 2022 ) and co-delivery of bioactive molecules ( Hopkins et al, 2022 ; Li et al, 2022 ), aided by the development of multifunctional nanoparticles. These are particularly encouraging as they may improve both the delivery and therapeutic efficiency ( Elhassan et al, 2022 ; Xu et al, 2022 ). In general, the design of a nanoparticle platform for delivery consists of a number of key features: 1) the nanoparticle core, 2) the surface functional groups, and 3) the bioactive molecules ( Yiu, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Gold-iron oxide (Au/Fe3O4) magnetic nanoparticles as the nanoplatform for binding of bioactive molecules through self-assembly

Lau

Åhlén²,

Cheung³

et al. 2023

Front. Mol. Biosci.

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Nanomedicine plays a crucial role in the development of next-generation therapies. The use of nanoparticles as drug delivery platforms has become a major area of research in nanotechnology. To be effective, these nanoparticles must interact with desired drug molecules and release them at targeted sites. The design of these “nanoplatforms” typically includes a functional core, an organic coating with functional groups for drug binding, and the drugs or bioactive molecules themselves. However, by exploiting the coordination chemistry between organic molecules and transition metal centers, the self-assembly of drugs onto the nanoplatform surfaces can bypass the need for an organic coating, simplifying the materials synthesis process. In this perspective, we use gold-iron oxide nanoplatforms as examples and outline the prospects and challenges of using self-assembly to prepare drug-nanoparticle constructs. Through a case study on the binding of insulin on Au-dotted Fe3O4 nanoparticles, we demonstrate how a self-assembly system can be developed. This method can also be adapted to other combinations of transition metals, with the potential for scaling up. Furthermore, the self-assembly method can also be considered as a greener alternative to traditional methods, reducing the use of chemicals and solvents. In light of the current climate of environmental awareness, this shift towards sustainability in the pharmaceutical industry would be welcomed.

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Engineering hybrid nanosystems for efficient and targeted delivery against bacterial infections

Cited by 22 publications

References 152 publications

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticlesin vivo

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticlesin vivo

Organically Modified Mesoporous Silica Nanoparticles against Bacterial Resistance

Gold-iron oxide (Au/Fe3O4) magnetic nanoparticles as the nanoplatform for binding of bioactive molecules through self-assembly

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