Engineering efficient artificial nanozyme based on chitosan grafted Fe-doped-carbon dots for bacteria biofilm eradication

Pan, Ting; Chen, Huanhuan; Gao, Xiang; Wu, Zeyu; Ye, Yingwang; Shen, Yizhong

doi:10.1016/j.jhazmat.2022.128996

Cited by 66 publications

(53 citation statements)

References 61 publications

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“…However, some individual studies have indicated that studied antibacterial active nanozymes have different killing effects on Gram-negative and Gram-positive bacteria. The designed nanozyme kills Pseudomonas aeruginosa more effectively than Staphylococcus aureus [33] . Therefore, the mechanism behind this needs to be carefully investigated.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

“…can improve their antimicrobial properties. Pan et al [33] compared the peroxidase-like activity of vigorous chitosan grafted Fe-doped carbon dots (CS@Fe/CDs) and without Fe-doped carbon dots (CS@CDs), found that nanozyme based on CS@Fe/CDs performs better catalytic activity. Authors pointed out that the mechanism of the peroxidase-like activity is increased electron density in the active center and reduced resistance of the steric sites due to the abundant carboxyl groups on the surface of the nanozyme, leading to an increased Fenton-like reaction.…”

Section: Mechanism Of Anti-microbial Infections Of Nanozymes 1generat...mentioning

confidence: 99%

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Nanozyme: A new Approach for Anti-microbial Infections

Xuetong¹,

Ruofei²,

Xiyun³

et al. 2022

Journal of Inorganic Materials

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Bacteria and viruses have always posed a threat to human health. Most impressively, SARS-CoV-2 has been raging around the world for almost three years, causing huge loss to human health. Facing increasing challenges of drugresistance and poor treatment efficacy, new solutions are urgently needed to combat pathogenic microorganisms. Recently, nanozymes with intrinsic enzyme-like activities have emerged as a promising new type of "antibiotics".Nanozymes exhibit superior antibacterial and antiviral activities under physiological conditions by efficiently catalyzing generation of a large number of reactive oxygen species. Moreover, enhanced therapeutic effects are achieved in nanozyme-based therapy aided by the unique physicochemical properties of nanomaterials such as photothermal and photodynamic effects. This paper reviews the latest research progress in the field of anti-microbial nanozymes, systematically summarizes and analyzes the principles of nanozymes in the treatment of bacteria and viruses from a mechanistic point of view. An outlook on the future direction and the challenges of new anti-microbial infection nanomaterials are proposed to provide inspiration for developing next generation anti-microbial nanozymes.

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Section: Conclusion and Discussionmentioning

confidence: 99%

Section: Mechanism Of Anti-microbial Infections Of Nanozymes 1generat...mentioning

confidence: 99%

Nanozyme: A new Approach for Anti-microbial Infections

Xuetong¹,

Ruofei²,

Xiyun³

et al. 2022

Journal of Inorganic Materials

View full text Add to dashboard Cite

show abstract

“…12, Pan et al assessed the level of residual eDNA within biofilms treated with Fe-CDs by agarose gel electrophoresis. 102 The results showed that the residual levels of DNA were significantly lower in biofilms treated with Fe-CDs plus H 2 O 2 than in the other groups. The antibiofilm ability of Fe-CDs is mainly attributed to the generation of toxic -OH triggered by a Fenton-like reaction, which allows the effective cleavage of eDNA around the biofilm microenvironment.…”

Section: Elimination Of Mature Established Biofilmmentioning

confidence: 91%

“…Fig.12(A) General design of CS@Fe/CDs-based nanozyme for bacterial biofilm elimination. (B) Bacterial biofilm eradication using CS@Fe/CDs-based nanozyme at 37.0 1C for 3.0 h. Reprinted with permission 102. …”

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confidence: 99%

Antibacterial and antibiofilm mechanisms of carbon dots: a review

Huang

et al. 2023

J. Mater. Chem. B

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“…Furthermore, the obtained Fe‐CDs showed negligible cytotoxicity on NIH‐3T3 cells and can induce E. coli ‐infected wound of the mice to heal. Likewise, Shen and co‐workers also designed another Fe‐CDs by a one‐pot hydrothermal method for bacteria biofilm eradication [111] . The obtained Fe‐CDs exhibited nanozymatic catalytic activity with the generation of ⋅OH in the presence of H 2 O 2 , inducing the colorless TMB to be blue oxidation product.…”

Section: M‐cds For Versatile Bio‐applicationsmentioning

confidence: 99%

Emerging and Versatile Platforms of Metal‐Ion‐Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

Qian

et al. 2022

ChemMedChem

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Metal ions possess abundant electrons and unoccupied orbitals, as well as large atomic radii, whose doping into carbon dots (CDs) is a facile strategy to endow CDs with additional physicochemical characteristics. After being doped with metal ions, CDs reveal obvious changes in their optical, electronic, and magnetic properties by adjustments to their electron density distribution and the energy gaps, leading them to be promising and competitive candidates as labeling probes, imaging agents, catalysts, nanodrugs, and so on. In this review, we summarize the fabrication methods of metal‐ion‐doped CDs (M‐CDs), and highlight their biological applications including biosensing, bioimaging, tumor therapy, and anti‐microbial treatment. Finally, the challenging future perspectives of M‐CDs are analyzed. We hope this review will provide inspiration for further development of M‐CDs in various biological aspects, and help readers who are interested in M‐CDs and their biological applications.

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Engineering efficient artificial nanozyme based on chitosan grafted Fe-doped-carbon dots for bacteria biofilm eradication

Cited by 66 publications

References 61 publications

Nanozyme: A new Approach for Anti-microbial Infections

Nanozyme: A new Approach for Anti-microbial Infections

Antibacterial and antibiofilm mechanisms of carbon dots: a review

Emerging and Versatile Platforms of Metal‐Ion‐Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

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