Engineering DNA/Fe–N–C single-atom nanozymes interface for colorimetric biosensing of cancer cells

Recent advances in colorimetric sensors based on nanozymes with peroxidase-like activity

“…Therefore, Sun L. P. et al synthesized DNA/Fe–N–C SAzymes conjugates by engineering DNA modification to Fe–N–C SAzymes. 140 This significantly enhanced the dispersibility of Fe–N–C SAzymes without affecting the peroxidase-like activity of Fe–N–C SAzymes. A HePG2 cancer cell sensor was established based on a diblock DNA (one polyadenine and one aptamer DNA sequence) attached to Fe–N–C SAzymes in HEPES containing MgCl 2 (Fig.…”

“…Fig. 15 Schematic diagram of Apt/Fe-N-C SAzymes preparation (A) and colorimetric detection of HePG2 cancer cells (B) 140. …”

MOFs and MOF-Derived Materials for Antibacterial Application

“…Other researchers found that co-calcining template MOFs directly with metal powder or foam also could form MOFs with new coordination environments [ 155 ]. Moreover, changing the ions provided by organic ligands in the coordination environment of active sites to ions with different electronegativity will cause uneven local charge distribution, which can accelerate the current transfer and catalyze the redox reaction of the material, producing antibacterial substances.…”

Single‐Atom Nanozymes for Biomedical Applications: Recent Advances and Challenges

“…However, there are two problems with SAzymes: first, they have low dispersion in solution [83] and tend to aggregate without achieving higher catalytic activity; second, they do not have the structure to specifically recognize biomolecules. [84] To address these two issues, Liping Sun et al [19] combined DNA engineering, also at the forefront of science and technology, with FeÀ NÀ C SAzymes to achieve effective detection of cancer cells. Combining the two improves the dispersion of the SAzymes in solution due to its high affinity for adenine and thymine, and achieves targeted binding to cancer cells due to the greater programmability of DNA.…”

“…Finally, in terms of application, a sensitive detection method for H 2 O 2 , glucose, and AA was developed with the optimized Cu-NC-700 SAzymes. Hongye FeÀ SSN [14] Fe [15] RuÀ AlaÀ C 3 N 4 [16] AÀ CoÀ NG [17] FeÀ NÀ C [18] Apt/FeÀ NÀ C [19] FeÀ NÀ C [20] Pt/NiCo-LDH [21] FeÀ NÀ C [22] CoÀ MoS 2 [23] FeÀ N/C [24] CoÀ NÀ C [25] Biomedical therapy Cancer…”