Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents

Abstract

The goal of this critical review is to provide a critical analysis of the chain dynamics responsible for the action of micro-and nanoparticles of mucoadhesive biomaterials. The objective of using bioadhesive controlled drug delivery devices is to prolong their residence at a specific site of delivery, thus enhancing the drug absorption process. These mucoadhesive devices can protect the drug during the absorption process in addition to protecting it on its route to the delivery site. The major emphasis of recent research on mucoadhesive biomaterials has been on the use of adhesion promoters, which would enhance the adhesion between synthetic polymers and mucus. The use of adhesion promoters such as linear or tethered polymer chains is a natural result of the diffusional characteristics of adhesion. Mucoadhesion depends largely on the structure of the synthetic polymer gels used in controlled release applications.

Bioadhesive drug delivery systems: Overview and recent advances

“…The stimulated Pathway dramatically increases the mucus secretion. (Serra, Doménech, and Peppas, 2009) Mucus is mainly composed of water (>95) and mucins, which are glycoproteins of very high molecular weight (2-14 x 10 12 g/mol). Along with these, proteins, lipids and mucopolysaccharides are found in small proportions (<1%).…”

Current Trends in MEMS Drug Delivery Techniques

“…Mucoadhesion process is implemented through following steps: First, intimate contact with the tissue is made by wetting and swelling of the polymer, then, entanglement between the polymer and the mucin chain is achieved and hence, weak chemical bonds start to form attaching the mucoadhesive device to the site [31], [32]. Another chemical approach involves the use of lectin as a target molecule to enhance adhesion.…”

Nanomedicine and Drug Delivery Strategies for Treatment of Genetic Diseases

“…Finally, effective accumulation within particular tissues requires penetration across cellular barriers. This is most evident in the example of diagnostic and therapeutic agents aimed to exert their activities in the central nervous systems (Pardridge, 2010), and those which need to be transported across the gastrointestinal epithelial layer upon oral administration (Kitchens, et al, 2005, Serra, et al, 2009, Park, et al, 2011. In addition, except for a few cases of vascular beds characterized by discontinuous endothelium where free diffusion is granted, transport of substances from the bloodstream into the irrigated tissues is regulated by the layer of endothelial cells that separate the microvascular wall from the tissue p a r e n c h y m a a n d t h i s p o s e s a n o b s t a c l e t o penetration (Pardridge, 2010).…”